{
  "id": 5407,
  "label": "ampulla of vater squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003490",
  "properties": {
    "xrefs": [
      "DOID:5527",
      "GARD:0023526",
      "MEDGEN:272304",
      "NCIT:C27417",
      "UMLS:C1332251"
    ],
    "synonyms": [
      "ampulla of Vater squamous cell carcinoma",
      "hepatopancreatic ampulla squamous cell carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A carcinoma with squamous differentiation arising from the ampulla of Vater. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 7758,
      "label": "extrahepatic bile duct squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5076,
        5414
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000248",
          "GARD:0024328",
          "NCIT:C5777"
        ],
        "synonyms": [
          "bile duct squamous cell carcinoma",
          "squamous cell bile duct carcinoma",
          "squamous cell carcinoma of bile duct",
          "squamous cell carcinoma of the bile duct",
          "extrahepatic bile duct squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the extrahepatic bile ducts. It is composed entirely by malignant squamous epithelial cells."
      },
      "child_count": 6,
      "reference_id": "MONDO:0006203"
    },
    {
      "id": 17870,
      "label": "carcinoma of the ampulla of vater",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3189,
        5076,
        20511
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4932",
          "EFO:1000079",
          "GARD:0021237",
          "MEDGEN:120461",
          "MedDRA:10048853",
          "NCIT:C3908",
          "ONCOTREE:AMPCA",
          "Orphanet:300557",
          "SCTID:254609000",
          "UMLS:C0262401",
          "icd11.foundation:267067189"
        ],
        "synonyms": [
          "Ampulloma",
          "ampulla of Vater cancer",
          "ampulla of Vater carcinoma",
          "ampullary cancer",
          "ampullary carcinoma",
          "carcinoma of ampulla of vater",
          "carcinoma of hepatopancreatic ampulla",
          "hepatopancreatic ampulla carcinoma",
          "AMPCA"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma arising from the ampulla of Vater. The vast majority of cases are adenocarcinomas. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss."
      },
      "child_count": 9,
      "reference_id": "MONDO:0017590"
    },
    {
      "id": 18541,
      "label": "squamous cell carcinoma of the small intestine",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6823,
        7176
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021764",
          "MEDGEN:313711",
          "NCIT:C43534",
          "Orphanet:423968",
          "UMLS:C1710111"
        ],
        "synonyms": [
          "small intestinal squamous cell cancer",
          "small intestinal squamous cell carcinoma",
          "small intestine squamous cell carcinoma",
          "squamous cell carcinoma of the small bowel"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the small intestine. It is composed of malignant squamous cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0018509"
    }
  ],
  "children": [
    {
      "id": 5456,
      "label": "ampulla of vater adenosquamous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5407,
        7757
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5628",
          "GARD:0023560",
          "MEDGEN:231056",
          "NCIT:C27418",
          "UMLS:C1332245"
        ],
        "synonyms": [
          "ampulla of Vater adenosquamous carcinoma",
          "hepatopancreatic ampulla adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma with glandular and squamous differentiation arising from the ampulla of Vater. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003553"
    }
  ],
  "roots": [
    {
      "id": 7758,
      "label": "extrahepatic bile duct squamous cell carcinoma"
    },
    {
      "id": 17870,
      "label": "carcinoma of the ampulla of vater"
    },
    {
      "id": 18541,
      "label": "squamous cell carcinoma of the small intestine"
    }
  ]
}