{
  "id": 5409,
  "label": "thymus squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003493",
  "properties": {
    "xrefs": [
      "DOID:5530",
      "EFO:1000579",
      "GARD:0023528",
      "MEDGEN:234814",
      "NCIT:C6455",
      "UMLS:C1336082"
    ],
    "synonyms": [
      "Thymus squamous cell carcinoma",
      "epidermoid thymic carcinoma",
      "squamous cell carcinoma of Thymus",
      "squamous cell carcinoma of the Thymus",
      "thymic squamous cell carcinoma",
      "thymus squamous cell carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A rare primary thymic carcinoma, characterized by the presence of keratinizing or non-keratinizing malignant squamous cells. Approximately 10-20% of cases occur in combination with thymoma. The prognosis depends on the tumor stage and the degree of cellular differentiation."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4600,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1749",
          "EFO:0000707",
          "ICDO:8070/3",
          "MEDGEN:2874",
          "MESH:D002294",
          "NCIT:C2929",
          "SCTID:402815007",
          "UMLS:C0007137"
        ],
        "synonyms": [
          "carcinoma, squamous cell, malignant",
          "epidermoid carcinoma",
          "epidermoid cell cancer",
          "malignant epidermoid cell neoplasm",
          "malignant epidermoid cell tumor",
          "malignant epidermoid cell tumour",
          "malignant squamous cell neoplasm",
          "malignant squamous cell tumor",
          "malignant squamous cell tumour",
          "squamous carcinoma",
          "squamous cell cancer",
          "squamous cell carcinoma",
          "squamous cell carcinoma (morphologic abnormality)",
          "squamous cell carcinoma NOS (morphologic abnormality)",
          "squamous cell epithelioma"
        ],
        "definition": "A carcinoma arising from squamous epithelial cells. Morphologically, it is characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded by the degree of cellular differentiation as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells. Representative examples are lung squamous cell carcinoma, skin squamous cell carcinoma, and cervical squamous cell carcinoma."
      },
      "child_count": 78,
      "reference_id": "MONDO:0005096"
    },
    {
      "id": 7956,
      "label": "thymic carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4646,
        6734,
        18240
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3284",
          "DOID:4554",
          "EFO:1000576",
          "GARD:0019695",
          "ICDO:8586/3",
          "MEDGEN:60049",
          "MedDRA:10061031",
          "NANDO:2200079",
          "NCIT:C7569",
          "NCIT:C7612",
          "ONCOTREE:THYC",
          "Orphanet:99868",
          "SCTID:444374006",
          "UMLS:C0205969",
          "icd11.foundation:1351671383"
        ],
        "synonyms": [
          "carcinoma of thymus",
          "malignant thymoma",
          "thymic carcinoma",
          "thymic carcinoma (excluding well differentiated thymic carcinoma)",
          "thymic carcinoma excluding well differentiated thymic carcinoma",
          "thymoma type C",
          "thymoma, malignant",
          "thymoma, malignant (morphologic abnormality)",
          "thymoma, type C (morphologic abnormality)",
          "thymus carcinoma",
          "type C thymoma",
          "THYC"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Thymic carcinoma (TC) is a type of thymic epithelial neoplasm characterized by a high malignant potential."
      },
      "child_count": 27,
      "reference_id": "MONDO:0006451"
    }
  ],
  "children": [
    {
      "id": 5455,
      "label": "thymic adenosquamous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5409,
        7652
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5626",
          "GARD:0023559",
          "MEDGEN:272286",
          "NCIT:C6458",
          "UMLS:C1332171"
        ],
        "synonyms": [
          "Thymus adenosquamous carcinoma",
          "adenosquamous carcinoma of Thymus",
          "adenosquamous carcinoma of the Thymus",
          "thymic adenosquamous carcinoma",
          "thymus adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare carcinoma that arises from the thymus and is characterized by the presence of glandular and squamous carcinomatous components."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003551"
    },
    {
      "id": 5927,
      "label": "thymic basaloid carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5405,
        5409
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7050",
          "GARD:0023815",
          "MEDGEN:231420",
          "NCIT:C6456",
          "UMLS:C1332464"
        ],
        "synonyms": [
          "Thymus basaloid carcinoma",
          "basaloid carcinoma of Thymus",
          "basaloid carcinoma of the Thymus",
          "thymic basaloid carcinoma",
          "thymus basaloid squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare primary thymic carcinoma, characterized by the presence of tumor cell lobules with peripheral palisading, and a basophilic staining pattern. More than half of reported cases were associated with the presence of a multilocular thymic cyst. Metastases to lung and liver have been reported in approximately 30% of cases."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004092"
    }
  ],
  "roots": [
    {
      "id": 6823,
      "label": "squamous cell carcinoma"
    },
    {
      "id": 7956,
      "label": "thymic carcinoma"
    }
  ]
}