{
  "id": 5418,
  "label": "anal canal neuroendocrine neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003504",
  "properties": {
    "xrefs": [
      "DOID:5545",
      "GARD:0023533",
      "MEDGEN:231063",
      "NCIT:C5603",
      "SCTID:717917007",
      "UMLS:C1332273"
    ],
    "synonyms": [
      "anal canal neuroendocrine neoplasm",
      "anal neuroendocrine neoplasm",
      "anus neuroendocrine neoplasm",
      "neuroendocrine neoplasm of anal canal",
      "neuroendocrine neoplasm of anus",
      "neuroendocrine neoplasm of the anus",
      "anal canal NET",
      "anal canal neuroendocrine tumor",
      "anal canal neuroendocrine tumor, well differentiated, low or intermediate grade",
      "anal canal neuroendocrine tumour",
      "anal neuroendocrine tumor",
      "anal neuroendocrine tumour",
      "anus neuroendocrine tumor",
      "anus neuroendocrine tumour",
      "neuroendocrine tumor of anus",
      "neuroendocrine tumour of anus"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A neoplasm with neuroendocrine differentiation that arises from the anal canal. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        19314,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1800",
          "GARD:0023067",
          "ICDO:8246/3",
          "MEDGEN:104919",
          "MESH:D018278",
          "NCIT:C3773",
          "SCTID:253000007",
          "UMLS:C0206695"
        ],
        "synonyms": [
          "NEC",
          "neuroendocrine cancer",
          "neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neuroendocrine neoplasm composed of cells containing secretory granules that stain positive for NSE and chromogranin. The neoplastic cells are often round and form clusters or trabecular sheets. Representative examples are small cell carcinoma, large cell neuroendocrine carcinoma, and Merkel cell carcinoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0002120"
    },
    {
      "id": 5534,
      "label": "rectum neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4896,
        21431
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5777",
          "GARD:0019756",
          "MEDGEN:277576",
          "NCIT:C5698",
          "UMLS:C1335686",
          "icd11.foundation:1619951900"
        ],
        "synonyms": [
          "neuroendocrine neoplasm of rectum",
          "neuroendocrine neoplasm of the rectum",
          "rectal neuroendocrine neoplasm",
          "rectum neuroendocrine neoplasm",
          "NET of the rectum",
          "neuroendocrine tumor of rectum",
          "neuroendocrine tumour of rectum",
          "rectal NET",
          "rectal neuroendocrine tumor",
          "rectum NET",
          "rectum neuroendocrine tumor",
          "rectum neuroendocrine tumor, well differentiated, low or intermediate grade",
          "rectum neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neoplasm with neuroendocrine differentiation that arises from the rectum. It includes well differentiated neuroendocrine tumors (low and intermediate grade) and poorly differentiated neuroendocrine carcinomas (high grade)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003646"
    },
    {
      "id": 8521,
      "label": "anal canal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2895,
        5158,
        18546
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6126",
          "GARD:0021772",
          "MEDGEN:107559",
          "NCIT:C7489",
          "OMIM:105580",
          "Orphanet:424013",
          "SCTID:285310000",
          "UMLS:C0563211"
        ],
        "synonyms": [
          "anal canal cancer",
          "anal canal and perianal gland cancer",
          "anal canal and perianal gland carcinoma",
          "anal canal carcinoma",
          "carcinoma of anal canal",
          "carcinoma of the anal canal",
          "cloacogenic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the anal canal"
      },
      "child_count": 15,
      "reference_id": "MONDO:0007108"
    }
  ],
  "children": [
    {
      "id": 16043,
      "label": "neuroendocrine tumor of the anal canal",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5418,
        16042
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019757",
          "MEDGEN:474482",
          "NCIT:C96540",
          "Orphanet:100082",
          "UMLS:C3272849",
          "icd11.foundation:1927831331"
        ],
        "synonyms": [
          "anal canal neuroendocrine neoplasm",
          "NET of anal canal",
          "NET of the anal canal",
          "anal NET",
          "anal Neuroendocrine tumor",
          "anal Neuroendocrine tumour",
          "anal canal NET",
          "anal canal neuroendocrine tumor",
          "anal canal neuroendocrine tumour",
          "anal canal well differentiated tumor",
          "anal canal well differentiated tumor/carcinoma",
          "anal canal well differentiated tumour",
          "neuroendocrine neoplasm of the anal canal",
          "neuroendocrine tumor of anal canal",
          "neuroendocrine tumour of anal canal"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the anal canal."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015069"
    }
  ],
  "roots": [
    {
      "id": 4255,
      "label": "neuroendocrine carcinoma"
    },
    {
      "id": 5534,
      "label": "rectum neuroendocrine neoplasm"
    },
    {
      "id": 8521,
      "label": "anal canal carcinoma"
    }
  ]
}