{
  "id": 5421,
  "label": "choriocarcinoma of ovary",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003507",
  "properties": {
    "xrefs": [
      "DOID:5550",
      "EFO:1000413",
      "GARD:0023536",
      "MEDGEN:91089",
      "NCIT:C4515",
      "SCTID:254870004",
      "UMLS:C0346181"
    ],
    "synonyms": [
      "choriocarcinoma of ovary",
      "choriocarcinoma of the ovary",
      "germ cell choriocarcinoma of ovary",
      "germ cell choriocarcinoma of the ovary",
      "ovarian choriocarcinoma",
      "ovarian germ cell choriocarcinoma",
      "ovary choriocarcinoma (disease)"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A choriocarcinoma arising from the ovary. When it appears before puberty is of germ cell origin. In children and young adults signs and symptoms include precocious pseudopuberty and vaginal bleeding. Serum human chorionic gonadotropin is elevated. Germ cell derived ovarian choriocarcinoma should be differentiated from primary or metastatic gestational choriocarcinoma affecting the ovary. The prognosis of germ cell derived choriocarcinoma is less favorable and requires more aggressive chemotherapy treatment regimens compared to gestational choriocarcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6924,
      "label": "choriocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4886,
        6773
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3594",
          "EFO:0002893",
          "GARD:0006059",
          "HP:0100768",
          "ICDO:9100/3",
          "MEDGEN:40278",
          "MESH:D002822",
          "NANDO:2200070",
          "NCIT:C2948",
          "ONCOTREE:BCCA",
          "SCTID:188188009",
          "UMLS:C0008497"
        ],
        "synonyms": [
          "chorioblastoma",
          "choriocarcinoma",
          "choriocarcinoma (disease)",
          "choriocarcinoma, malignant",
          "chorioepithelioma",
          "chorion carcinoma",
          "chorionic carcinoma"
        ],
        "definition": "An aggressive malignant tumor arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Approximately half of the cases develop from a complete hydatidiform mole. A minority of cases arise in the testis or the ovaries. There is often marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected."
      },
      "child_count": 16,
      "reference_id": "MONDO:0005207"
    },
    {
      "id": 18315,
      "label": "malignant germ cell tumor of ovary",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7832,
        12476,
        18335,
        18448
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2155",
          "GARD:0009330",
          "MEDGEN:87544",
          "NCIT:C4514",
          "Orphanet:35807",
          "SCTID:254869000",
          "UMLS:C0346180"
        ],
        "synonyms": [
          "MOGCT",
          "malignant germ cell neoplasm of ovary",
          "malignant germ cell neoplasm of the ovary",
          "malignant germ cell tumor of ovary",
          "malignant germ cell tumor of the ovary",
          "malignant germ cell tumour of the ovary",
          "malignant ovarian germ cell neoplasm",
          "malignant ovarian germ cell tumor",
          "malignant ovarian germ cell tumour",
          "ovarian germ cell cancer",
          "ovary malignant germ cell tumor",
          "ovary malignant germ cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Malignant germ cell tumor of ovary is a rare ovarian cancer arising from germ cells in the ovary, frequently unilateral at diagnosis which characteristically presents during adolescence with pelvic mass, fever, vaginal bleeding and acute abdomen."
      },
      "child_count": 16,
      "reference_id": "MONDO:0018171"
    }
  ],
  "children": [
    {
      "id": 6111,
      "label": "gestational ovarian choriocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5421,
        16723,
        19993
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7591",
          "GARD:0023917",
          "MEDGEN:274586",
          "NCIT:C40442",
          "UMLS:C1517538"
        ],
        "synonyms": [
          "gestational ovarian choriocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare malignant trophoblastic tumor that arises from the ovary as a result of ectopic ovarian pregnancy. There is no germ cell component present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004294"
    },
    {
      "id": 6138,
      "label": "non-gestational ovarian choriocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5339,
        5421
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7665",
          "GARD:0023934",
          "MEDGEN:274798",
          "NCIT:C39991",
          "UMLS:C1518355"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor that arises from the ovary and is composed of cytotrophoblasts, syncytiotrophoblasts, and extravillous trophoblasts. The prognosis is less favorable than gestational choriocarcinoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004322"
    }
  ],
  "roots": [
    {
      "id": 6924,
      "label": "choriocarcinoma"
    },
    {
      "id": 18315,
      "label": "malignant germ cell tumor of ovary"
    }
  ]
}