{
  "id": 5422,
  "label": "choriocarcinoma of testis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003508",
  "properties": {
    "xrefs": [
      "DOID:5551",
      "EFO:1000564",
      "GARD:0023537",
      "MEDGEN:65969",
      "NCIT:C7733",
      "ONCOTREE:TCCA",
      "UMLS:C0238449",
      "icd11.foundation:1972827817"
    ],
    "synonyms": [
      "choriocarcinoma of testis",
      "choriocarcinoma of the testis",
      "testicular choriocarcinoma",
      "testis choriocarcinoma (disease)",
      "choriocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A malignant germ cell tumor arising from the testis. It represents the rarest of the testicular germ cell tumors. Histologically it is characterized by the presence of syncytiotrophoblasts and cytotrophoblasts."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4885,
      "label": "testicular trophoblastic tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4886,
        4887,
        7954
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4084",
          "GARD:0023283",
          "MEDGEN:272844",
          "NCIT:C39934",
          "UMLS:C1515301"
        ],
        "synonyms": [
          "testicular trophoblastic tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A tumor that arises from the testis and is composed of neoplastic trophoblastic cells. The vast majority of cases are choriocarcinomas."
      },
      "child_count": 3,
      "reference_id": "MONDO:0002871"
    },
    {
      "id": 5335,
      "label": "testicular non-seminomatous germ cell cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5424,
        7954
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5345",
          "GARD:0023503",
          "MEDGEN:233162",
          "NCIT:C5027",
          "UMLS:C1334625"
        ],
        "synonyms": [
          "malignant non-seminomatous germ cell cancer of testis",
          "malignant non-seminomatous germ cell cancer of the testis",
          "malignant non-seminomatous germ cell neoplasm of testis",
          "malignant non-seminomatous germ cell neoplasm of the testis",
          "malignant non-seminomatous germ cell tumor of testis",
          "malignant non-seminomatous germ cell tumor of the testis",
          "malignant non-seminomatous germ cell tumour of testis",
          "malignant non-seminomatous germ cell tumour of the testis",
          "malignant testicular non-seminomatous germ cell neoplasm",
          "malignant testicular non-seminomatous germ cell tumor",
          "malignant testicular non-seminomatous germ cell tumour",
          "testicular germ cell tumor non-seminomatous, malignant",
          "testicular germ cell tumour non-seminomatous, malignant",
          "testicular non-seminomatous germ cell cancer",
          "testicular non-seminomatous germ cell tumor, malignant",
          "testicular non-seminomatous malignant germ cell neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A classification of testicular cancers that arise in specialized sex cells called germ cells. Nonseminomas include embryonal carcinoma, teratoma, choriocarcinoma, and yolk sac tumor."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003403"
    },
    {
      "id": 6924,
      "label": "choriocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4886,
        6773
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3594",
          "EFO:0002893",
          "GARD:0006059",
          "HP:0100768",
          "ICDO:9100/3",
          "MEDGEN:40278",
          "MESH:D002822",
          "NANDO:2200070",
          "NCIT:C2948",
          "ONCOTREE:BCCA",
          "SCTID:188188009",
          "UMLS:C0008497"
        ],
        "synonyms": [
          "chorioblastoma",
          "choriocarcinoma",
          "choriocarcinoma (disease)",
          "choriocarcinoma, malignant",
          "chorioepithelioma",
          "chorion carcinoma",
          "chorionic carcinoma"
        ],
        "definition": "An aggressive malignant tumor arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Approximately half of the cases develop from a complete hydatidiform mole. A minority of cases arise in the testis or the ovaries. There is often marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected."
      },
      "child_count": 16,
      "reference_id": "MONDO:0005207"
    }
  ],
  "children": [
    {
      "id": 5665,
      "label": "childhood testicular choriocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5422,
        5638,
        6283
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6160",
          "GARD:0023670",
          "MEDGEN:272469",
          "NCIT:C6544",
          "UMLS:C1333006"
        ],
        "synonyms": [
          "childhood choriocarcinoma of testis",
          "childhood choriocarcinoma of the testis",
          "childhood testicular choriocarcinoma",
          "choriocarcinoma of testis of childhood",
          "paediatric choriocarcinoma of testis",
          "paediatric choriocarcinoma of the testis",
          "paediatric testicular choriocarcinoma",
          "pediatric choriocarcinoma of testis",
          "pediatric choriocarcinoma of the testis",
          "pediatric testicular choriocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A choriocarcinoma that arises from the testis during childhood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003786"
    },
    {
      "id": 5823,
      "label": "testicular monophasic choriocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5422
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6693",
          "GARD:0023756",
          "MEDGEN:272841",
          "NCIT:C39935",
          "UMLS:C1515290"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A choriocarcinoma that arises from the testis and is characterized by the predominance of cytotrophoblastic and intermediate trophoblastic cells. Syncytiotrophoblastic cells are absent or not prominent."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003966"
    }
  ],
  "roots": [
    {
      "id": 4885,
      "label": "testicular trophoblastic tumor"
    },
    {
      "id": 5335,
      "label": "testicular non-seminomatous germ cell cancer"
    },
    {
      "id": 6924,
      "label": "choriocarcinoma"
    }
  ]
}