{
  "id": 5424,
  "label": "malignant testicular germ cell tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003510",
  "properties": {
    "xrefs": [
      "DOID:5556",
      "GARD:0023539",
      "ICD9:186.9",
      "MEDGEN:163616",
      "NCIT:C9063",
      "SCTID:713646001",
      "UMLS:C0855197"
    ],
    "synonyms": [
      "testicular cancer",
      "malignant germ cell neoplasm of testis",
      "malignant germ cell neoplasm of the testis",
      "malignant germ cell tumor of testis",
      "malignant germ cell tumor of the testis",
      "malignant germ cell tumour of testis",
      "malignant germ cell tumour of the testis",
      "malignant testicular germ cell neoplasm",
      "malignant testicular germ cell tumor",
      "testicular ca. (no germ/tropho.)",
      "testicular cancer (excluding germ cell or trophoblastic cancer)",
      "testicular germ cell cancer",
      "testicular malignant germ cell cancer"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A malignant tumor predominantly affecting young men and often associated with cryptorchidism. Seminoma is the most frequently seen malignant testicular germ cell tumor, followed by embryonal carcinoma and yolk sac tumor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 7111,
      "label": "testicular cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7450,
        20517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2998",
          "EFO:0005088",
          "ICD10CM:C62",
          "ICD9:186",
          "ICD9:186.9",
          "MEDGEN:56313",
          "MESH:D013736",
          "NCIT:C7251",
          "SCTID:363449006",
          "UMLS:C0153594"
        ],
        "synonyms": [
          "testicular tumor",
          "testicular tumour",
          "testis neoplasm",
          "cancer of testis",
          "malignant neoplasm of testis",
          "malignant neoplasm of the testis",
          "malignant testicular neoplasm",
          "malignant testicular tumor",
          "malignant testicular tumour",
          "malignant testis neoplasm",
          "malignant tumor of testis",
          "malignant tumor of the testis",
          "malignant tumour of testis",
          "malignant tumour of the testis",
          "testis cancer",
          "paediatric testicular neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm that affects the testis. Representative examples include seminoma, embryonal carcinoma, sarcoma, leukemia, and lymphoma."
      },
      "child_count": 22,
      "reference_id": "MONDO:0005447"
    },
    {
      "id": 7832,
      "label": "malignant germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        6773
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000352",
          "GARD:0003360",
          "MEDGEN:890580",
          "NCIT:C4925",
          "SCTID:145831000119103",
          "UMLS:C4048549"
        ],
        "synonyms": [
          "cancer of germ cell",
          "germ cell cancer",
          "germ cell tumor, malignant",
          "malignant germ cell neoplasm",
          "malignant germ cell tumor",
          "malignant neoplasm of germ cell",
          "malignant neoplasm of the germ cell",
          "malignant tumor of germ cell",
          "malignant tumor of the germ cell",
          "malignant tumour of germ cell",
          "malignant tumour of the germ cell"
        ],
        "definition": "A gonadal or extragonadal malignant neoplasm that arises from germ cells. Representative examples include embryonal carcinoma, yolk sac tumor, and seminoma."
      },
      "child_count": 26,
      "reference_id": "MONDO:0006290"
    },
    {
      "id": 11294,
      "label": "testicular germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18335,
        20517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5557",
          "EFO:1000566",
          "GARD:0013047",
          "ICD9:239.5",
          "MEDGEN:277809",
          "MESH:C563236",
          "NCIT:C8591",
          "OMIM:273300",
          "Orphanet:363504",
          "SCTID:713577007",
          "UMLS:C1336708"
        ],
        "synonyms": [
          "TGCT",
          "germ cell neoplasm of testis",
          "germ cell neoplasm of the testis",
          "germ cell tumor of testis",
          "germ cell tumor of the testis",
          "germ cell tumors, somatic",
          "germ cell tumour of testis",
          "germ cell tumour of the testis",
          "male germ cell tumor, somatic",
          "spermatocytic seminoma, somatic",
          "testicular germ cell neoplasm",
          "testicular germ cell neoplasms",
          "testicular germ cell tumor",
          "testicular tumor, somatic",
          "testis germ cell tumor",
          "testis germ cell tumour",
          "Male germ cell tumor",
          "Male germ cell tumour",
          "embryonal cell carcinoma",
          "endodermal sinus tumor",
          "endodermal sinus tumour",
          "nonseminomatous germ cell tumors",
          "nonseminomatous germ cell tumours",
          "seminoma",
          "spermatocytic seminoma",
          "teratoma, testicular",
          "testicular germ cell cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A germ cell tumor arising from the testis. Representative examples include teratoma, seminoma, embryonal carcinoma, and yolk sac tumor."
      },
      "child_count": 12,
      "reference_id": "MONDO:0010108"
    }
  ],
  "children": [
    {
      "id": 5098,
      "label": "mixed testicular germ cell cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5424,
        16596
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4743",
          "GARD:0023372",
          "MEDGEN:237005",
          "NCIT:C6347",
          "ONCOTREE:MGCT",
          "UMLS:C1336720"
        ],
        "synonyms": [
          "mixed germ cell neoplasm of testis",
          "mixed germ cell neoplasm of the testis",
          "mixed germ cell tumor",
          "mixed germ cell tumor of testis",
          "mixed germ cell tumor of the testis",
          "mixed germ cell tumour",
          "mixed germ cell tumour of testis",
          "mixed germ cell tumour of the testis",
          "mixed testicular germ cell tumor",
          "mixed testicular germ cell tumour",
          "testicular germ cell tumor (mixed)",
          "testicular germ cell tumour (mixed)",
          "testicular mixed germ cell neoplasm",
          "testicular mixed germ cell tumor",
          "testicular mixed germ cell tumour",
          "testis mixed germ cell tumor",
          "testis mixed germ cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor that arises from the testis and is characterized by the presence of more than one histologic component. Representative examples include mixed choriocarcinoma and embryonal carcinoma, mixed embryonal carcinoma and seminoma, and mixed yolk sac tumor and teratoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003120"
    },
    {
      "id": 5335,
      "label": "testicular non-seminomatous germ cell cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5424,
        7954
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5345",
          "GARD:0023503",
          "MEDGEN:233162",
          "NCIT:C5027",
          "UMLS:C1334625"
        ],
        "synonyms": [
          "malignant non-seminomatous germ cell cancer of testis",
          "malignant non-seminomatous germ cell cancer of the testis",
          "malignant non-seminomatous germ cell neoplasm of testis",
          "malignant non-seminomatous germ cell neoplasm of the testis",
          "malignant non-seminomatous germ cell tumor of testis",
          "malignant non-seminomatous germ cell tumor of the testis",
          "malignant non-seminomatous germ cell tumour of testis",
          "malignant non-seminomatous germ cell tumour of the testis",
          "malignant testicular non-seminomatous germ cell neoplasm",
          "malignant testicular non-seminomatous germ cell tumor",
          "malignant testicular non-seminomatous germ cell tumour",
          "testicular germ cell tumor non-seminomatous, malignant",
          "testicular germ cell tumour non-seminomatous, malignant",
          "testicular non-seminomatous germ cell cancer",
          "testicular non-seminomatous germ cell tumor, malignant",
          "testicular non-seminomatous malignant germ cell neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A classification of testicular cancers that arise in specialized sex cells called germ cells. Nonseminomas include embryonal carcinoma, teratoma, choriocarcinoma, and yolk sac tumor."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003403"
    },
    {
      "id": 5554,
      "label": "testicular seminoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4887,
        5000,
        5424
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5842",
          "EFO:0003101",
          "GARD:0004792",
          "HP:0100617",
          "ICD9:186.9",
          "MEDGEN:1790467",
          "NCIT:C7328",
          "Orphanet:842",
          "SCTID:255107005",
          "UMLS:C5551428"
        ],
        "synonyms": [
          "seminoma of testis",
          "seminoma of the testis",
          "seminomatous germ cell tumor of testis",
          "seminomatous germ cell tumour of testis",
          "testicular seminoma",
          "testicular seminoma (disease)",
          "testicular seminoma Pure",
          "testicular seminomatous germ cell tumor",
          "testicular seminomatous germ cell tumour",
          "testis seminoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor arising from the testis. It is believed that it is derived from the sexually undifferentiated embryonic gonad. Treatment with radiotherapy is highly successful when the tumor is diagnosed in localized stages, which represents the majority of presentations of seminoma."
      },
      "child_count": 12,
      "reference_id": "MONDO:0003669"
    },
    {
      "id": 6210,
      "label": "testis refractory cancer",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5424,
        22941
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7928",
          "GARD:0023980",
          "MEDGEN:235122",
          "NCIT:C9077",
          "UMLS:C1377904"
        ],
        "synonyms": [
          "refractory cancer of testis",
          "refractory cancer of the testis",
          "refractory malignant testicular germ cell tumor",
          "refractory malignant testicular germ cell tumour",
          "refractory testicular cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Malignant testicular germ cell tumor that is resistant to treatment."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004401"
    },
    {
      "id": 6248,
      "label": "testis polyembryoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5424,
        16595
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8042",
          "GARD:0024008",
          "MEDGEN:271324",
          "NCIT:C40962",
          "UMLS:C1514200"
        ],
        "synonyms": [
          "polyembryoma of testis",
          "polyembryoma of the testis",
          "testicular polyembryoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare malignant germ cell tumor that arises from the testis and is characterized by the presence of embryoid bodies."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004442"
    },
    {
      "id": 20473,
      "label": "malignant teratoma of testis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5424,
        5427
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025305",
          "ICD9:186.9",
          "MEDGEN:232636",
          "NCIT:C6353",
          "SCTID:416769008",
          "UMLS:C1334154",
          "icd11.foundation:1214355345"
        ],
        "synonyms": [
          "immature teratoma of testis",
          "immature teratoma of the testis",
          "immature testicular teratoma",
          "malignant teratoma of the testis",
          "malignant testicular teratoma",
          "testicular immature teratoma",
          "testicular malignant teratoma",
          "testis malignant teratoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant teratoma that involves the testis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021282"
    }
  ],
  "roots": [
    {
      "id": 7111,
      "label": "testicular cancer"
    },
    {
      "id": 7832,
      "label": "malignant germ cell tumor"
    },
    {
      "id": 11294,
      "label": "testicular germ cell tumor"
    }
  ]
}