{
  "id": 5427,
  "label": "malignant teratoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003514",
  "properties": {
    "xrefs": [
      "DOID:5563",
      "GARD:0023541",
      "MEDGEN:1652407",
      "NCIT:C4287",
      "UMLS:C4722083"
    ],
    "synonyms": [
      "teratoma, malignant",
      "malignant extragonadal teratoma"
    ],
    "definition": "A malignant form of teratoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 4656,
      "label": "teratoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3307",
          "GARD:0023184",
          "ICDO:9080/1",
          "MEDGEN:21097",
          "MESH:D013724",
          "NCIT:C3403",
          "ONCOTREE:TT",
          "SCTID:36591000119102",
          "UMLS:C0039538"
        ],
        "synonyms": [
          "teratoma"
        ],
        "definition": "A non-seminomatous germ cell tumor characterized by the presence of various tissues which correspond to the different germinal layers (endoderm, mesoderm, and ectoderm). It occurs in the testis, ovary, and extragonadal sites including central nervous system, mediastinum, lung, and stomach. According to the level of differentiation of the tissues which comprise the tumor, teratomas are classified as mature or immature. Mature teratomas are composed of well differentiated, adult-type tissues. Immature teratomas are composed of immature, fetal-type tissues. Testicular teratomas in children follow a benign clinical course. Mature ovarian teratomas without a fetal-type component have an excellent outcome. The prognosis of immature ovarian teratomas is related to the grade and stage of the tumor."
      },
      "child_count": 13,
      "reference_id": "MONDO:0002601"
    },
    {
      "id": 7832,
      "label": "malignant germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        6773
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000352",
          "GARD:0003360",
          "MEDGEN:890580",
          "NCIT:C4925",
          "SCTID:145831000119103",
          "UMLS:C4048549"
        ],
        "synonyms": [
          "cancer of germ cell",
          "germ cell cancer",
          "germ cell tumor, malignant",
          "malignant germ cell neoplasm",
          "malignant germ cell tumor",
          "malignant neoplasm of germ cell",
          "malignant neoplasm of the germ cell",
          "malignant tumor of germ cell",
          "malignant tumor of the germ cell",
          "malignant tumour of germ cell",
          "malignant tumour of the germ cell"
        ],
        "definition": "A gonadal or extragonadal malignant neoplasm that arises from germ cells. Representative examples include embryonal carcinoma, yolk sac tumor, and seminoma."
      },
      "child_count": 26,
      "reference_id": "MONDO:0006290"
    }
  ],
  "children": [
    {
      "id": 5866,
      "label": "pineal region immature teratoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4216,
        5427,
        5475,
        5615,
        5864,
        21584
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6858",
          "GARD:0023779",
          "MEDGEN:277516",
          "NCIT:C6755",
          "UMLS:C1335416"
        ],
        "synonyms": [
          "atypical pineal teratoma",
          "immature teratoma of pineal area",
          "immature teratoma of pineal region",
          "immature teratoma of the pineal area",
          "immature teratoma of the pineal region",
          "pineal area immature teratoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0004017"
    },
    {
      "id": 5889,
      "label": "immature gastric teratoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5093,
        5426,
        5427,
        5475
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6948",
          "GARD:0023792",
          "MEDGEN:272752",
          "NCIT:C5256",
          "UMLS:C1334151"
        ],
        "synonyms": [
          "immature gastric teratoma",
          "malignant teratoma of the stomach",
          "stomach malignant teratoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant teratoma that arises from the stomach."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004048"
    },
    {
      "id": 5967,
      "label": "intermediate malignant teratoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5427
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7202",
          "GARD:0023842",
          "ICDO:9083/3",
          "MEDGEN:83161",
          "NCIT:C4288",
          "UMLS:C0334522"
        ],
        "synonyms": [
          "Intermediate immature teratoma",
          "malignant teratoma, intermediate",
          "malignant teratoma, intermediate (morphologic abnormality)"
        ],
        "definition": "An immature teratoma characterized by the presence of an intermediate amount of undifferentiated tissues."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004140"
    },
    {
      "id": 18450,
      "label": "immature ovarian teratoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5427,
        5691,
        16723
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6331",
          "GARD:0021654",
          "MEDGEN:138044",
          "NCIT:C39995",
          "NCIT:C8111",
          "ONCOTREE:OIMT",
          "Orphanet:398987",
          "SCTID:254871000",
          "UMLS:C0346182",
          "icd11.foundation:551209361"
        ],
        "synonyms": [
          "immature germ cell teratoma of ovary",
          "immature germ cell teratoma of the ovary",
          "immature ovarian teratoma",
          "immature teratoma of ovary",
          "immature teratoma of the ovary",
          "malignant germ cell teratoma of ovary",
          "malignant germ cell teratoma of the ovary",
          "malignant ovarian germ cell teratoma",
          "malignant ovarian teratoma",
          "malignant teratoma of ovary",
          "malignant teratoma of the ovary",
          "ovarian germ cell immature teratoma",
          "ovarian immature germ cell teratoma",
          "ovarian immature teratoma",
          "ovarian malignant teratoma",
          "ovary malignant teratoma",
          "immature teratoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor arising from the ovary. It usually affects females in their first two decades of life. It contains variable amounts of immature embryonal tissues. Based on the amount of immature neuroepithelial component, immature teratomas are graded from 1 to 3. The stage and grade of the tumor and the grade of the metastatic tumor are the important factors that predict prognosis. The use of cisplatin-based combination chemotherapy has significantly improved the survival rates of the patients."
      },
      "child_count": 6,
      "reference_id": "MONDO:0018369"
    },
    {
      "id": 20473,
      "label": "malignant teratoma of testis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5424,
        5427
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025305",
          "ICD9:186.9",
          "MEDGEN:232636",
          "NCIT:C6353",
          "SCTID:416769008",
          "UMLS:C1334154",
          "icd11.foundation:1214355345"
        ],
        "synonyms": [
          "immature teratoma of testis",
          "immature teratoma of the testis",
          "immature testicular teratoma",
          "malignant teratoma of the testis",
          "malignant testicular teratoma",
          "testicular immature teratoma",
          "testicular malignant teratoma",
          "testis malignant teratoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant teratoma that involves the testis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021282"
    },
    {
      "id": 20474,
      "label": "malignant teratoma of mediastinum",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5427,
        5431,
        5475,
        7838
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025306",
          "MEDGEN:91164",
          "NCIT:C4668",
          "SCTID:278042005",
          "UMLS:C0349663"
        ],
        "synonyms": [
          "immature malignant teratoma of mediastinum",
          "immature malignant teratoma of the mediastinum",
          "malignant mediastinal teratoma",
          "malignant teratoma of the mediastinum",
          "mediastinal immature malignant teratoma",
          "mediastinum malignant teratoma"
        ],
        "definition": "A malignant teratoma that involves the mediastinum."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021283"
    },
    {
      "id": 21594,
      "label": "immature extragonadal teratoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5427,
        5475,
        21584
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025465",
          "MEDGEN:167781",
          "NCIT:C8884",
          "UMLS:C0855163"
        ],
        "synonyms": [
          "extragonadal primary malignant teratoma",
          "immature extragonadal teratoma",
          "malignant extragonadal teratoma",
          "primary malignant extragonadal teratoma"
        ],
        "definition": "An immature teratoma that develops as a primary tumor in an anatomic site other than the testis or ovary."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024857"
    }
  ],
  "roots": [
    {
      "id": 4656,
      "label": "teratoma"
    },
    {
      "id": 7832,
      "label": "malignant germ cell tumor"
    }
  ]
}