{
  "id": 5434,
  "label": "gastrin-producing neuroendocrine tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003523",
  "properties": {
    "xrefs": [
      "DOID:5577",
      "GARD:0023546",
      "ICDO:8153/1",
      "MEDGEN:6551",
      "NANDO:2200395",
      "NCIT:C3050",
      "UMLS:C0017150",
      "icd11.foundation:1333125891"
    ],
    "synonyms": [
      "G cell tumor",
      "G cell tumour",
      "G-cell gastrin producing tumor",
      "G-cell gastrin producing tumour",
      "G-cell tumor",
      "G-cell tumour",
      "gastrin cell tumor",
      "gastrin secreting tumor",
      "gastrin secreting tumour",
      "gastrin-producing NET",
      "gastrin-producing neuroendocrine tumor",
      "gastrinoma",
      "malignant gastrinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A gastrin-producing neuroendocrine tumor. It is usually located in the pancreas but it is also found at other anatomic sites, including the stomach and small intestine."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 2885,
      "label": "digestive system neuroendocrine tumor, grade 1/2",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050626",
          "GARD:0022761",
          "MEDGEN:443945",
          "NCIT:C95404",
          "ONCOTREE:GINET",
          "UMLS:C2930967"
        ],
        "synonyms": [
          "alimentary part of gastrointestinal system neuroendocrine tumor",
          "alimentary part of gastrointestinal system neuroendocrine tumour",
          "digestive system NET",
          "digestive system neuroendocrine tumor",
          "digestive system neuroendocrine tumour",
          "digestive system well differentiated neuroendocrine tumor",
          "digestive system well differentiated neuroendocrine tumour",
          "gastroenteropancreatic NET",
          "gastroenteropancreatic neuroendocrine tumor",
          "gastroenteropancreatic neuroendocrine tumour",
          "gastrointestinal NET",
          "gastrointestinal neuroendocrine tumor",
          "gastrointestinal neuroendocrine tumors",
          "gastrointestinal neuroendocrine tumour",
          "gastrointestinal neuroendocrine tumours",
          "gastrointestinal system neuroendocrine tumor",
          "gastrointestinal system neuroendocrine tumour",
          "malignant gastrointestinal neuroendocrine tumor",
          "malignant gastrointestinal neuroendocrine tumour",
          "GINET"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well-differentiated neuroendocrine tumor arising from the digestive system. It is characterized by the presence of cells with features similar to those of the normal endocrine cells of the digestive system. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation and hormones. There is mild to moderate nuclear atypia and less than 20 mitoses per 10 HPF. It includes well-differentiated endocrine tumors or carcinoid tumors and well-differentiated endocrine carcinomas."
      },
      "child_count": 10,
      "reference_id": "MONDO:0000386"
    }
  ],
  "children": [
    {
      "id": 5435,
      "label": "gastric gastrin-producing neuroendocrine tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5434,
        16036
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5579",
          "GARD:0023547",
          "MEDGEN:232230",
          "NCIT:C27444",
          "UMLS:C1333767"
        ],
        "synonyms": [
          "gastric G-cell gastrin producing tumour",
          "gastric gastrin producing tumor",
          "gastric gastrin producing tumour",
          "gastric gastrin-producing NET",
          "gastric gastrin-producing neuroendocrine tumor",
          "gastrin producing neuroendocrine tumor of the stomach",
          "gastrin producing neuroendocrine tumour of the stomach",
          "gastrin producing tumor of the stomach",
          "gastrin producing tumour of the stomach",
          "gastrin-producing neuroendocrine tumor of stomach",
          "gastrin-producing neuroendocrine tumor of the stomach",
          "gastrin-producing neuroendocrine tumour of stomach",
          "gastrin-producing neuroendocrine tumour of the stomach",
          "stomach gastrin-producing neuroendocrine tumor",
          "stomach gastrin-producing neuroendocrine tumour",
          "gastric gastrinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated neuroendocrine tumor that arises from the stomach. It produces gastrin and it may be associated with Zollinger-Ellison syndrome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003524"
    },
    {
      "id": 5436,
      "label": "pancreatic gastrin-producing neuroendocrine tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5434,
        19671
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5580",
          "GARD:0023548",
          "MEDGEN:235080",
          "MESH:D015408",
          "NCIT:C9069",
          "UMLS:C1368066"
        ],
        "synonyms": [
          "gastrin-producing neuroendocrine tumor of pancreas",
          "gastrin-producing neuroendocrine tumour of pancreas",
          "pancreas gastrin-producing neuroendocrine tumor",
          "pancreas gastrin-producing neuroendocrine tumour",
          "pancreatic G-cell tumour",
          "pancreatic gastrin producing NET",
          "pancreatic gastrin producing tumor",
          "pancreatic gastrin producing tumour",
          "pancreatic gastrin-producing neuroendocrine tumor",
          "islet cell tumor, ulcerogenic"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A usually malignant gastrin-producing neuroendocrine tumor arising from the pancreas. It may or may not be associated with inappropriate secretion of gastrin and an associated clinical syndrome."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003525"
    },
    {
      "id": 6220,
      "label": "duodenal gastrin-producing neuroendocrine tumor",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5434,
        16037
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7959",
          "GARD:0023989",
          "MEDGEN:272550",
          "NCIT:C5731",
          "UMLS:C1333321"
        ],
        "synonyms": [
          "duodenal G-cell gastrin producing tumor",
          "duodenal G-cell gastrin producing tumour",
          "duodenal gastrin-producing NET",
          "duodenal gastrin-producing neuroendocrine tumor",
          "duodenal gastrinoma",
          "duodenum gastrin-producing neuroendocrine tumor",
          "duodenum gastrin-producing neuroendocrine tumour",
          "gastrin producing tumor of duodenum",
          "gastrin producing tumor of the duodenum",
          "gastrin producing tumour of duodenum",
          "gastrin producing tumour of the duodenum",
          "gastrin-producing neuroendocrine tumor of duodenum",
          "gastrin-producing neuroendocrine tumour of duodenum",
          "gastrinoma of duodenum",
          "gastrinoma of the duodenum"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A gastrin-producing neuroendocrine tumor that arises from the duodenum. It is characterized by the presence of uniform cells that form pseudorosettes. The neoplastic cells have uniform nuclei and small amount of eosinophilic cytoplasm."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004411"
    }
  ],
  "roots": [
    {
      "id": 2885,
      "label": "digestive system neuroendocrine tumor, grade 1/2"
    }
  ]
}