{
  "id": 5443,
  "label": "T lymphoblastic leukemia/lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003537",
  "properties": {
    "xrefs": [
      "DOID:5599",
      "GARD:0023552",
      "ICDO:9837/3",
      "MEDGEN:224897",
      "NCIT:C8694",
      "UMLS:C1301359"
    ],
    "synonyms": [
      "precursor T lymphoblastic leukemia/lymphoma",
      "precursor T lymphoblastic lymphoma/leukemia",
      "precursor T-lymphoblastic lymphoma/leukemia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A neoplasm of lymphoblasts committed to the T-cell lineage, typically composed of small to medium-sized blast cells. When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is called T acute lymphoblastic leukemia. When it involves nodal or extranodal sites it is called T lymphoblastic lymphoma. (WHO, 2001)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 5444,
      "label": "precursor lymphoblastic lymphoma/leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6881
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5600",
          "GARD:0023553",
          "MEDGEN:235492",
          "NCIT:C7055",
          "UMLS:C1335469"
        ],
        "synonyms": [
          "precursor lymphoblastic leukemia/lymphoma",
          "precursor lymphoblastic lymphoma/leukemia",
          "precursor lymphoid neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm of immature malignant lymphocytes (lymphoblasts) committed to the B-cell or T-cell lineage. Neoplasms involving the bone marrow and the peripheral blood are called precursor lymphoblastic leukemias or acute lymphoblastic leukemias. Neoplasms involving primarily lymph nodes or extranodal sites are called lymphoblastic lymphomas. -- 2003"
      },
      "child_count": 4,
      "reference_id": "MONDO:0003538"
    },
    {
      "id": 21530,
      "label": "T-cell and NK-cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6881
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009622",
          "MEDGEN:277781",
          "NCIT:C27908",
          "UMLS:C1336554"
        ],
        "synonyms": [
          "T-cell and NK-cell neoplasm",
          "T-cell neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0024615"
    }
  ],
  "children": [
    {
      "id": 6212,
      "label": "childhood precursor T-lymphoblastic lymphoma/leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5443,
        8005
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7933",
          "GARD:0023982",
          "MEDGEN:232067",
          "NCIT:C5640",
          "UMLS:C1332997"
        ],
        "synonyms": [
          "childhood T lymphoblastic leukemia/lymphoma",
          "childhood precursor T-lymphoblastic lymphoma/leukemia",
          "paediatric precursor T-lymphoblastic lymphoma/leukemia",
          "pediatric precursor T-lymphoblastic lymphoma/leukemia",
          "precursor T-lymphoblastic lymphoma/leukemia of childhood"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A T lymphoblastic leukemia/lymphoma that occurs during childhood."
      },
      "child_count": 4,
      "reference_id": "MONDO:0004403"
    },
    {
      "id": 6213,
      "label": "refractory precursor T-lymphoblastic lymphoma/leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5443,
        5945
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7936",
          "GARD:0023983",
          "MEDGEN:167728",
          "NCIT:C8696",
          "UMLS:C0854859"
        ],
        "synonyms": [
          "precursor T lymphoblastic lymphoma/leukemia refractory",
          "refractory T lymphoblastic leukemia/lymphoma",
          "refractory precursor T-lymphoblastic lymphoma/leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "T-lymphoblastic leukemia/lymphoma resistant to treatment"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004404"
    },
    {
      "id": 19293,
      "label": "T-cell prolymphocytic leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2906,
        3282,
        5443,
        6706
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081042",
          "EFO:1000560",
          "GARD:0013731",
          "ICDO:9834/3",
          "MEDGEN:391707",
          "MESH:D015461",
          "MedDRA:10042985",
          "NCIT:C4752",
          "ONCOTREE:TPLL",
          "Orphanet:86871",
          "SCTID:277545003",
          "SCTID:277567002",
          "UMLS:C2363142",
          "icd11.foundation:352523899"
        ],
        "synonyms": [
          "CLL, T-cell",
          "T cell CLL",
          "T cell chronic lymphocytic leukaemia",
          "T cell chronic lymphocytic leukemia",
          "T cell prolymphocytic leukaemia",
          "T cell prolymphocytic leukemia",
          "T prolymphocytic leukaemia",
          "T prolymphocytic leukemia",
          "T-PLL",
          "T-cell CLL",
          "T-cell chronic lymphocytic leukaemia",
          "T-cell chronic lymphocytic leukemia",
          "T-cell prolymphocytic leukemia",
          "chronic T-cell leukaemia",
          "chronic T-cell leukemia",
          "chronic T-cell lymphocytic leukaemia",
          "chronic T-cell lymphocytic leukemia",
          "TPLL",
          "leukemia, T-cell, chronic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A slow-growing type of leukemia (blood cancer) in which too many lymphocytes are found in the bone marrow and/or blood. The T-cell is specified as the defective cell line."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019468"
    },
    {
      "id": 19295,
      "label": "aggressive NK-cell leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2906,
        3274,
        5443,
        6706
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1035",
          "GARD:0010493",
          "ICDO:9948/3",
          "MEDGEN:266235",
          "MedDRA:10028811",
          "NANDO:2200012",
          "NCIT:C8647",
          "ONCOTREE:ANKL",
          "Orphanet:86873",
          "SCTID:721310007",
          "UMLS:C1292777",
          "icd11.foundation:153957345"
        ],
        "synonyms": [
          "ANKCL",
          "NK cell leukaemia",
          "NK cell leukemia",
          "NK-cell LGL leukaemia",
          "NK-cell LGL leukemia",
          "NK-cell large granular lymphocyte leukaemia",
          "NK-cell large granular lymphocyte leukemia",
          "NK-cell leukaemia",
          "NK-cell leukemia",
          "aggressive NK-cell leukaemia (morphologic abnormality)",
          "aggressive NK-cell leukemia",
          "aggressive NK-cell leukemia (morphologic abnormality)",
          "aggressive NK-cell leukemia/lymphoma",
          "aggressive NK-cell lymphoma",
          "leukaemia (disease) of natural killer cell",
          "leukemia (disease) of natural killer cell",
          "natural Killer cell leukemia",
          "natural killer cell leukaemia (disease)",
          "natural killer cell leukemia",
          "natural killer cell leukemia (disease)",
          "ANKL",
          "aggressive NK cell leukaemia",
          "aggressive NK cell leukemia",
          "aggressive natural killer cell leukaemia",
          "aggressive natural killer cell leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare, highly aggressive, Epstein-Barr virus-associated leukemia, also known as aggressive NK-cell leukemia/lymphoma; it may represent the leukemic counterpart of nasal type extranodal NK/T-cell lymphomas. It affects primarily teenagers and young adults. It is characterized by the systemic proliferation of NK cells in the peripheral blood, bone marrow, liver, and spleen."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019470"
    },
    {
      "id": 23479,
      "label": "T-lymphoblastic lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3163,
        5443,
        16517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025922",
          "MEDGEN:266232",
          "NANDO:2200023",
          "NCIT:C6919",
          "SCTID:421246008",
          "UMLS:C1292758"
        ],
        "synonyms": [
          "Precur. T-lymphoblastic lymphoma",
          "T Lymphoblastic lymphoma",
          "T-Lymphoblastic lymphoma",
          "T-lymphoblastic lymphoma",
          "precursor T Lymphoblastic lymphoma",
          "precursor T-Lymphoblastic lymphoma",
          "precursor T-cell Lymphoblastic lymphoma",
          "precursor T-lymphoblastic lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "The most frequent type of lymphoblastic lymphoma. It comprises approximately 85-90% of cases. It is more frequently seen in adolescent males. It frequently presents with a mass lesion in the mediastinum. Pleural effusions are common. (WHO, 2001)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0044917"
    }
  ],
  "roots": [
    {
      "id": 5444,
      "label": "precursor lymphoblastic lymphoma/leukemia"
    },
    {
      "id": 21530,
      "label": "T-cell and NK-cell neoplasm"
    }
  ]
}