{
  "id": 5475,
  "label": "extragonadal nonseminomatous germ cell tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003578",
  "properties": {
    "xrefs": [
      "DOID:5677",
      "GARD:0023567",
      "MEDGEN:233662",
      "NCIT:C8885",
      "UMLS:C1334582"
    ],
    "synonyms": [
      "cancer of extragonadal non-seminomatous germ cell",
      "cancer of the extragonadal non-seminomatous germ cell",
      "extragonadal non-seminomatous germ cell cancer",
      "extragonadal primary Nonseminoma",
      "malignant extragonadal Nonseminoma",
      "malignant extragonadal non-seminomatous germ cell neoplasm",
      "malignant extragonadal non-seminomatous germ cell tumor",
      "malignant extragonadal non-seminomatous germ cell tumour",
      "malignant neoplasm of extragonadal non-seminomatous germ cell",
      "malignant neoplasm of the extragonadal non-seminomatous germ cell",
      "malignant tumor of extragonadal non-seminomatous germ cell",
      "malignant tumor of the extragonadal non-seminomatous germ cell",
      "malignant tumour of extragonadal non-seminomatous germ cell",
      "malignant tumour of the extragonadal non-seminomatous germ cell",
      "primary malignant extragonadal Nonseminoma"
    ],
    "definition": "A malignant non-seminomatous germ cell tumor that develops as a primary tumor in an anatomic site other than the testis or ovary."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 10,
  "parents": [
    {
      "id": 5094,
      "label": "extragonadal germ cell cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7832,
        18334
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4717",
          "GARD:0023371",
          "MEDGEN:235292",
          "NCIT:C8881",
          "UMLS:C1334581"
        ],
        "synonyms": [
          "extragonadal germ cell malignant tumour",
          "extragonadal germ cell tumor, malignant",
          "malignant extragonadal germ cell tumor",
          "malignant extragonadal germ cell tumour",
          "malignant neoplasm of extragonadal germ cell",
          "malignant neoplasm of the extragonadal germ cell",
          "malignant tumor of extragonadal germ cell",
          "malignant tumor of the extragonadal germ cell",
          "malignant tumour of extragonadal germ cell",
          "malignant tumour of the extragonadal germ cell",
          "tumour of extragonadal germ cell"
        ],
        "definition": "A malignant germ cell tumor that develops as a primary tumor in an anatomic site other than the testis or ovary."
      },
      "child_count": 18,
      "reference_id": "MONDO:0003113"
    },
    {
      "id": 19983,
      "label": "extragonadal non-dysgerminomatous germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18334,
        20708
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019706",
          "MEDGEN:1843056",
          "Orphanet:99913",
          "UMLS:C5681817"
        ]
      },
      "child_count": 8,
      "reference_id": "MONDO:0020539"
    }
  ],
  "children": [
    {
      "id": 5866,
      "label": "pineal region immature teratoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4216,
        5427,
        5475,
        5615,
        5864,
        21584
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6858",
          "GARD:0023779",
          "MEDGEN:277516",
          "NCIT:C6755",
          "UMLS:C1335416"
        ],
        "synonyms": [
          "atypical pineal teratoma",
          "immature teratoma of pineal area",
          "immature teratoma of pineal region",
          "immature teratoma of the pineal area",
          "immature teratoma of the pineal region",
          "pineal area immature teratoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0004017"
    },
    {
      "id": 5889,
      "label": "immature gastric teratoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5093,
        5426,
        5427,
        5475
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6948",
          "GARD:0023792",
          "MEDGEN:272752",
          "NCIT:C5256",
          "UMLS:C1334151"
        ],
        "synonyms": [
          "immature gastric teratoma",
          "malignant teratoma of the stomach",
          "stomach malignant teratoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant teratoma that arises from the stomach."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004048"
    },
    {
      "id": 7107,
      "label": "embryonal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5475
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3308",
          "EFO:0004986",
          "GARD:0005140",
          "ICDO:9070/3",
          "MEDGEN:61653",
          "MESH:D018236",
          "NANDO:2200067",
          "NCIT:C3752",
          "ONCOTREE:EMBCA",
          "Orphanet:180226",
          "UMLS:C0206659"
        ],
        "synonyms": [
          "carcinoma, embryonal, malignant",
          "embryonal carcinoma",
          "primary extragonadal embryonal carcinoma"
        ],
        "definition": "A non-seminomatous malignant germ cell tumor characterized by the presence of large germ cells with abundant cytoplasm resembling epithelial cells, geographic necrosis, high mitotic activity, and pseudoglandular and pseudopapillary structures formation. It can arise from the testis, ovary, and extragonadal sites (central nervous system and mediastinum)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005440"
    },
    {
      "id": 7365,
      "label": "yolk sac tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5475
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1911",
          "EFO:0007252",
          "GARD:0000348",
          "ICDO:9071/3",
          "MEDGEN:41782",
          "MedDRA:10048251",
          "NANDO:2200069",
          "NCIT:C3011",
          "ONCOTREE:BYST",
          "Orphanet:876",
          "SCTID:404081005",
          "UMLS:C0014145"
        ],
        "synonyms": [
          "endodermal sinus neoplasm",
          "endodermal sinus tumor",
          "hepatoid yolk sac tumor",
          "yolk SAC tumor, malignant",
          "yolk Sac neoplasm",
          "yolk Sac tumor",
          "yolk Sac tumor site unspecified",
          "yolk Sac tumour site unspecified",
          "yolk sac tumor",
          "infantile embryonal carcinoma"
        ],
        "definition": "A non-seminomatous malignant germ cell tumor composed of primitive germ cells. It is the most common malignant germ cell tumor in the pediatric population. It occurs in the infant testis, ovary, sacrococcygeal region, vagina, uterus, prostate, abdomen, liver, retroperitoneum, thorax, and pineal/third ventricle. The tumor mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). Treatment includes: surgical resection, radiation, and chemotherapy. This tumor is very responsive to chemotherapy regimens that include cisplatinum."
      },
      "child_count": 7,
      "reference_id": "MONDO:0005744"
    },
    {
      "id": 7775,
      "label": "gastric choriocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5093,
        5475,
        6924
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000269",
          "GARD:0024337",
          "MEDGEN:459624",
          "NCIT:C95749",
          "UMLS:C2987398"
        ],
        "synonyms": [
          "gastric choriocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor that arises from the stomach. It is characterized by the presence of syncytiotrophoblast and cytotrophoblast cellular components. It is often associated with lymph node and hematogenous metastases."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006222"
    },
    {
      "id": 16595,
      "label": "polyembryoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5475
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009621",
          "MEDGEN:83160",
          "NANDO:2200068",
          "NCIT:C66776",
          "Orphanet:180229",
          "UMLS:C0334518"
        ],
        "synonyms": [
          "gonadal polyembryoma"
        ],
        "definition": "Polyembryoma is a type oftumor that develops from the cells of the gonads (testes in men or ovaries in women). Such tumors are called germ cell tumors. Polyembryomas have a distinctivelook because they are composed of many parts that are shaped like embryos, one of the earliest stages of a developing human during pregnancy. Symptoms of a polyembryoma may include an unusual bump or mass in the abdomen which can cause pain in some individuals; puberty at an unusually young age (known as precocious puberty); or irregularities in a female's menstruation. Treatment begins with surgery and may be followed by chemotherapy and/or radiation therapy. The cause of polyembryoma is not yet known."
      },
      "child_count": 2,
      "reference_id": "MONDO:0015863"
    },
    {
      "id": 17190,
      "label": "choriocarcinoma of the central nervous system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        5475,
        6924,
        20012
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020734",
          "MEDGEN:234100",
          "NCIT:C7012",
          "Orphanet:252015",
          "UMLS:C1332876",
          "icd11.foundation:511691786"
        ],
        "synonyms": [
          "central nervous system choriocarcinoma",
          "central nervous system choriocarcinoma (disease)",
          "choriocarcinoma of CNS",
          "choriocarcinoma of the CNS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor of the central nervous system characterized by extra-embryonic differentiation along trophoblastic lines. The diagnosis requires the identification of cytotrophoblastic elements, as well as syncytiotrophoblastic giant cells. (WHO)"
      },
      "child_count": 12,
      "reference_id": "MONDO:0016740"
    },
    {
      "id": 19993,
      "label": "gestational choriocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3637,
        5475,
        6924,
        18866
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2025",
          "GARD:0019712",
          "ICD9:181",
          "MEDGEN:138102",
          "NCIT:C4646",
          "Orphanet:99926",
          "SCTID:417570003",
          "UMLS:C0349557",
          "icd11.foundation:2136066651"
        ],
        "synonyms": [
          "gestational choriocarcinoma",
          "gestational choriocarcinoma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "Gestational choriocarcinoma is a gestational trophoblastic tumor (GTT) occurring secondary to pregnancy (ectopic or normal), miscarriage, voluntary termination of pregnancy (VTP) or a hydatidiform mole."
      },
      "child_count": 16,
      "reference_id": "MONDO:0020550"
    },
    {
      "id": 20474,
      "label": "malignant teratoma of mediastinum",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5427,
        5431,
        5475,
        7838
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025306",
          "MEDGEN:91164",
          "NCIT:C4668",
          "SCTID:278042005",
          "UMLS:C0349663"
        ],
        "synonyms": [
          "immature malignant teratoma of mediastinum",
          "immature malignant teratoma of the mediastinum",
          "malignant mediastinal teratoma",
          "malignant teratoma of the mediastinum",
          "mediastinal immature malignant teratoma",
          "mediastinum malignant teratoma"
        ],
        "definition": "A malignant teratoma that involves the mediastinum."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021283"
    },
    {
      "id": 21594,
      "label": "immature extragonadal teratoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5427,
        5475,
        21584
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025465",
          "MEDGEN:167781",
          "NCIT:C8884",
          "UMLS:C0855163"
        ],
        "synonyms": [
          "extragonadal primary malignant teratoma",
          "immature extragonadal teratoma",
          "malignant extragonadal teratoma",
          "primary malignant extragonadal teratoma"
        ],
        "definition": "An immature teratoma that develops as a primary tumor in an anatomic site other than the testis or ovary."
      },
      "child_count": 0,
      "reference_id": "MONDO:0024857"
    }
  ],
  "roots": [
    {
      "id": 5094,
      "label": "extragonadal germ cell cancer"
    },
    {
      "id": 19983,
      "label": "extragonadal non-dysgerminomatous germ cell tumor"
    }
  ]
}