{
  "id": 5537,
  "label": "esophageal neuroendocrine tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003649",
  "properties": {
    "xrefs": [
      "DOID:5784",
      "GARD:0022058",
      "MEDGEN:459486",
      "NCIT:C95616",
      "Orphanet:506136",
      "UMLS:C2987260",
      "icd11.foundation:1167478749",
      "icd11.foundation:890879256"
    ],
    "synonyms": [
      "NEN of esophagus",
      "NEN of oesophagus",
      "esophageal NEN",
      "esophageal NET",
      "esophageal neuroendocrine neoplasm",
      "esophageal neuroendocrine tumor",
      "esophageal well differentiated endocrine tumor",
      "esophageal well differentiated endocrine tumor/carcinoma",
      "esophageal well differentiated endocrine tumour",
      "esophagus NET",
      "esophagus neuroendocrine neoplasm",
      "esophagus neuroendocrine tumor",
      "esophagus neuroendocrine tumor, well differentiated, low or intermediate grade",
      "neuroendocrine neoplasm of esophagus",
      "neuroendocrine neoplasm of oesophagus",
      "neuroendocrine tumour of oesophagus",
      "oesophagus NET",
      "oesophagus neuroendocrine neoplasm",
      "oesophagus neuroendocrine tumor, well differentiated, low or intermediate grade",
      "oesophagus neuroendocrine tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the esophagus."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 2885,
      "label": "digestive system neuroendocrine tumor, grade 1/2",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050626",
          "GARD:0022761",
          "MEDGEN:443945",
          "NCIT:C95404",
          "ONCOTREE:GINET",
          "UMLS:C2930967"
        ],
        "synonyms": [
          "alimentary part of gastrointestinal system neuroendocrine tumor",
          "alimentary part of gastrointestinal system neuroendocrine tumour",
          "digestive system NET",
          "digestive system neuroendocrine tumor",
          "digestive system neuroendocrine tumour",
          "digestive system well differentiated neuroendocrine tumor",
          "digestive system well differentiated neuroendocrine tumour",
          "gastroenteropancreatic NET",
          "gastroenteropancreatic neuroendocrine tumor",
          "gastroenteropancreatic neuroendocrine tumour",
          "gastrointestinal NET",
          "gastrointestinal neuroendocrine tumor",
          "gastrointestinal neuroendocrine tumors",
          "gastrointestinal neuroendocrine tumour",
          "gastrointestinal neuroendocrine tumours",
          "gastrointestinal system neuroendocrine tumor",
          "gastrointestinal system neuroendocrine tumour",
          "malignant gastrointestinal neuroendocrine tumor",
          "malignant gastrointestinal neuroendocrine tumour",
          "GINET"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well-differentiated neuroendocrine tumor arising from the digestive system. It is characterized by the presence of cells with features similar to those of the normal endocrine cells of the digestive system. The neoplastic cells express immunohistochemical evidence of neuroendocrine differentiation and hormones. There is mild to moderate nuclear atypia and less than 20 mitoses per 10 HPF. It includes well-differentiated endocrine tumors or carcinoid tumors and well-differentiated endocrine carcinomas."
      },
      "child_count": 10,
      "reference_id": "MONDO:0000386"
    },
    {
      "id": 20522,
      "label": "neoplasm of esophagus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5629,
        20434
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:4547",
          "NCIT:C3028",
          "SCTID:126817006",
          "UMLS:C0014859"
        ],
        "synonyms": [
          "esophageal neoplasm",
          "esophageal neoplasms, benign and malignant",
          "esophageal tumor",
          "esophageal tumors",
          "esophageal tumour",
          "esophageal tumours",
          "esophagus neoplasm",
          "esophagus neoplasm (disease)",
          "esophagus tumor",
          "neoplasm of esophagus",
          "neoplasm of the esophagus",
          "neoplasm of the oesophagus",
          "oesophagus neoplasm",
          "oesophagus neoplasm (disease)",
          "oesophagus tumour",
          "tumor of esophagus",
          "tumor of the esophagus",
          "tumour of oesophagus",
          "tumour of the oesophagus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A neoplasm (disease) that involves the esophagus."
      },
      "child_count": 10,
      "reference_id": "MONDO:0021355"
    }
  ],
  "children": [
    {
      "id": 5948,
      "label": "esophageal small cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2894,
        5537,
        18977
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7134",
          "GARD:0023832",
          "MEDGEN:207270",
          "NCIT:C6762",
          "UMLS:C1112474"
        ],
        "synonyms": [
          "Oat cell carcinoma of esophagus",
          "Oat cell carcinoma of the esophagus",
          "Oat cell carcinoma of the oesophagus",
          "esophageal Oat cell carcinoma",
          "esophageal small cell NEC",
          "esophageal small cell carcinoma",
          "esophageal small cell neuroendocrine carcinoma",
          "esophagus Oat cell carcinoma",
          "esophagus small cell carcinoma",
          "oesophagus Oat cell carcinoma",
          "small cell carcinoma of esophagus",
          "small cell carcinoma of oesophagus",
          "small cell carcinoma of the esophagus",
          "small cell carcinoma of the oesophagus",
          "small cell carcinoma, esophagus",
          "small cell carcinoma, oesophagus"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the esophagus. It is characterized by the presence of malignant small cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004116"
    }
  ],
  "roots": [
    {
      "id": 2885,
      "label": "digestive system neuroendocrine tumor, grade 1/2"
    },
    {
      "id": 20522,
      "label": "neoplasm of esophagus"
    }
  ]
}