{
  "id": 5550,
  "label": "hemolytic anemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003664",
  "properties": {
    "xrefs": [
      "DOID:583",
      "GARD:0023610",
      "ICD10CM:D55-D59",
      "MEDGEN:1916",
      "MESH:D000743",
      "NANDO:2200636",
      "NCIT:C34376",
      "SCTID:61261009",
      "UMLS:C0002878"
    ],
    "synonyms": [
      "anaemia hemolytic",
      "anemia hemolytic",
      "anemia, hemolytic",
      "hemolytic anemia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Anemia resulting from the premature destruction of the peripheral blood red cells. It may be congenital or it may be caused by infections, medications, or malignancies."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 11,
  "parents": [
    {
      "id": 5966,
      "label": "normocytic anemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4394
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:720",
          "ICD9:285.8",
          "MEDGEN:39310",
          "NCIT:C35142",
          "SCTID:300980002",
          "UMLS:C0085577"
        ],
        "synonyms": [
          "anaemia normocytic",
          "anemia normocytic",
          "normocytic Anaemia",
          "normocytic Anemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Anemia in which the red blood cell volume is normal."
      },
      "child_count": 1,
      "reference_id": "MONDO:0004139"
    }
  ],
  "children": [
    {
      "id": 5573,
      "label": "familial hemolytic anemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5550,
        5714
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:589",
          "GARD:0006167",
          "ICD9:282",
          "ICD9:282.9",
          "MEDGEN:1919",
          "MESH:D000745",
          "NANDO:2100183",
          "NCIT:C34379",
          "SCTID:42601008",
          "UMLS:C0002881"
        ],
        "synonyms": [
          "congenital hemolytic anemia",
          "hereditary hemolytic anemia",
          "anaemia hemolytic congenital",
          "anemia hemolytic congenital"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A congenital hemolytic anemia caused by defects of the erythrocyte membrane, enzyme deficiencies, or hemoglobinopathies."
      },
      "child_count": 46,
      "reference_id": "MONDO:0003689"
    },
    {
      "id": 9059,
      "label": "Heinz body anemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5550
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0111363",
          "GARD:0010718",
          "HP:0005511",
          "MEDGEN:148583",
          "MESH:C563030",
          "MedDRA:10002058",
          "OMIM:140700",
          "Orphanet:178330",
          "UMLS:C0700299"
        ],
        "synonyms": [
          "Heinz body anemias, alpha-",
          "Heinz body anemias"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0007705"
    },
    {
      "id": 12025,
      "label": "lethal hemolytic anemia-genital anomalies syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        5550
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002642",
          "MEDGEN:333019",
          "MESH:C563935",
          "OMIM:600461",
          "Orphanet:1046",
          "UMLS:C1838120"
        ],
        "synonyms": [
          "water-West syndrome",
          "hemolytic anaemia lethal congenital nonspherocytic with genital and other abnormalities",
          "hemolytic anemia lethal congenital nonspherocytic with genital and other abnormalities",
          "hemolytic anemia, lethal congenital nonspherocytic, with genital and other abnormalities"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Waters-West syndrome is characterized by the association of lethal non-spherocytic, non-immune hemolytic anemia with abnormalities of the external genitalia (micropenis and hypospadias), flat occiput, dimpled earlobes, deep plantar creases, and increased space between the first and second toes. It has been described only once in two brothers who died a few hours after birth. The second-born infant had massive ascites and hepatosplenomegaly. The mother had two spontaneous abortions (at 6 and 12 weeks gestation) but gave birth to a normal girl, suggesting an autosomal or X-linked recessive mode of inheritance. Although the parents were not known to be consanguineous, they shared a French-Canadian and American Indian ethnic origin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0010891"
    },
    {
      "id": 17508,
      "label": "hemolytic disease of the newborn with Kell alloimmunization",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5550
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021038",
          "MEDGEN:632769",
          "Orphanet:275944",
          "UMLS:C0472751"
        ],
        "synonyms": [
          "anti-K HDN",
          "maternal anti-Kell alloimmunization"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0017164"
    },
    {
      "id": 17638,
      "label": "hereditary elliptocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5550
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2373",
          "GARD:0006621",
          "ICD10CM:D58.1",
          "MEDGEN:41747",
          "MESH:D004612",
          "MedDRA:10014490",
          "NANDO:2200630",
          "NCIT:C35882",
          "NORD:1935",
          "Orphanet:288",
          "SCTID:178935009",
          "UMLS:C0013902",
          "icd11.foundation:679955609"
        ],
        "synonyms": [
          "HE",
          "Hashimoto Encephalopathy",
          "congenital elliptocytosis",
          "hereditary ovalocytosis",
          "ovalocytosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hereditary elliptocytosis (HE) is a rare clinically and genetically heterogeneous disorder of the red cell membrane characterized by manifestations ranging from mild to severe transfusion-dependent hemolytic anemia but with the majority of patients being asymptomatic."
      },
      "child_count": 5,
      "reference_id": "MONDO:0017319"
    },
    {
      "id": 19346,
      "label": "Shiga toxin-associated hemolytic uremic syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5550,
        22768
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006588",
          "MEDGEN:383843",
          "NANDO:2200640",
          "Orphanet:90038",
          "UMLS:C1856143"
        ],
        "synonyms": [
          "D+HUS",
          "STEC Hemolytic Uremic Syndrome",
          "Shiga-like toxin-associated HUS",
          "Sxt-HUS",
          "hemolytic-uremic syndrome with diarrhea",
          "hemolytic-uremic syndrome with diarrhoea",
          "typical HUS",
          "typical hemolytic-uremic syndrome",
          "D-plus hemolytic uremic syndrome (D+HUS)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare thrombotic microangiopathy characterized by mechanical hemolytic anemia, thrombocytopenia, and renal dysfunction that is usually associated with prodromal enteritis caused by Shigella dysentriae type 1 or E. Coli."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019536"
    },
    {
      "id": 19735,
      "label": "hereditary stomatocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5550
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019456",
          "ICD9:282.8",
          "MEDGEN:490161",
          "NANDO:2200623",
          "Orphanet:98365",
          "SCTID:14087004",
          "UMLS:C1262483",
          "icd11.foundation:2067120097"
        ],
        "synonyms": [
          "hereditary stomatocytic disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 7,
      "reference_id": "MONDO:0020102"
    },
    {
      "id": 19736,
      "label": "autoimmune hemolytic anemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3016,
        5550
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:0427-1178",
          "DOID:718",
          "EFO:1001264",
          "GARD:0005870",
          "ICD9:283.0",
          "MEDGEN:1918",
          "MESH:D000744",
          "MedDRA:10002046",
          "NANDO:1200305",
          "NANDO:2100181",
          "NCIT:C34378",
          "NORD:774",
          "OMIM:205700",
          "Orphanet:98375",
          "SCTID:413603009",
          "UMLS:C0002880",
          "icd11.foundation:1834341306"
        ],
        "synonyms": [
          "AHA",
          "AIHA",
          "Anemia, Hemolytic, Acquired Autoimmune",
          "autoimmune haemolytic anemia",
          "autoimmune hemolytic anemia",
          "acquired autoimmune hemolytic anaemia",
          "acquired autoimmune hemolytic anemia",
          "anaemia hemolytic autoimmune",
          "anemia hemolytic autoimmune",
          "anemia, autoimmune hemolytic",
          "familial auto-immune hemolytic anaemia (subtype)",
          "familial auto-immune hemolytic anemia (subtype)",
          "idiopathic autoimmune hemolytic anaemia",
          "idiopathic autoimmune hemolytic anemia",
          "immuno-hemolytic anaemia",
          "immuno-hemolytic anemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder in which various types of auto-antibodies are directed against red blood cells causing their survival to be shortened and resulting in hemolytic anemia."
      },
      "child_count": 14,
      "reference_id": "MONDO:0020108"
    },
    {
      "id": 19916,
      "label": "6-phosphogluconate dehydrogenase deficiency",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5550
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016897",
          "MEDGEN:1783871",
          "OMIM:619199",
          "Orphanet:99135",
          "UMLS:C5543091"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0020457"
    },
    {
      "id": 20665,
      "label": "non-autoimmune hemolytic anemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5550
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0005558",
          "GARD:0025337",
          "ICD9:283.10",
          "ICD9:283.19",
          "MEDGEN:45122",
          "NCIT:C34853",
          "SCTID:191216004",
          "UMLS:C0028283"
        ],
        "synonyms": [
          "non-autoimmune hemolytic anemia",
          "Non-Autoimmune Hemolytic Anaemia",
          "Non-Autoimmune Hemolytic Anemia",
          "Non-autoimmune hemolytic anaemia",
          "Non-autoimmune hemolytic anemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hemolytic anemia that is not mediated by immune mechanisms."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021559"
    },
    {
      "id": 23983,
      "label": "paroxysmal nocturnal hemoglobinuria",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5544,
        5550,
        7996,
        16404,
        21353
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060284",
          "GARD:0007337",
          "HGNC:8957",
          "HP:0004818",
          "ICD10CM:D59.5",
          "MEDGEN:7471",
          "MedDRA:10034042",
          "NCIT:C61233",
          "NORD:1557",
          "OMIMPS:300818",
          "Orphanet:447",
          "SCTID:1963002",
          "UMLS:C0024790",
          "icd11.foundation:859588467"
        ],
        "synonyms": [
          "Marchiafava-Micheli disease",
          "PNH",
          "acquired paroxysmal nocturnal hemoglobinuria",
          "hereditary paroxysmal nocturnal hemoglobinuria",
          "inherited paroxysmal nocturnal hemoglobinuria",
          "paroxysmal hemoglobinuria"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disorder characterized by corpuscular hemolytic anemia, bone marrow failure and frequent thrombotic events."
      },
      "child_count": 10,
      "reference_id": "MONDO:0100244"
    }
  ],
  "roots": [
    {
      "id": 5966,
      "label": "normocytic anemia"
    }
  ]
}