{
  "id": 5554,
  "label": "testicular seminoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003669",
  "properties": {
    "xrefs": [
      "DOID:5842",
      "EFO:0003101",
      "GARD:0004792",
      "HP:0100617",
      "ICD9:186.9",
      "MEDGEN:1790467",
      "NCIT:C7328",
      "Orphanet:842",
      "SCTID:255107005",
      "UMLS:C5551428"
    ],
    "synonyms": [
      "seminoma of testis",
      "seminoma of the testis",
      "seminomatous germ cell tumor of testis",
      "seminomatous germ cell tumour of testis",
      "testicular seminoma",
      "testicular seminoma (disease)",
      "testicular seminoma Pure",
      "testicular seminomatous germ cell tumor",
      "testicular seminomatous germ cell tumour",
      "testis seminoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A malignant germ cell tumor arising from the testis. It is believed that it is derived from the sexually undifferentiated embryonic gonad. Treatment with radiotherapy is highly successful when the tumor is diagnosed in localized stages, which represents the majority of presentations of seminoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 4887,
      "label": "testicular pure germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        11294
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4087",
          "GARD:0023284",
          "MEDGEN:308089",
          "NCIT:C39915",
          "UMLS:C1514608"
        ],
        "synonyms": [
          "testicular Pure germ cell tumor",
          "testicular Pure germ cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A germ cell tumor that arises from the testis and is characterized by the presence of one histologic component. This category includes seminoma, teratoma, embryonal carcinoma, yolk sac tumor, and trophoblastic tumor."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002874"
    },
    {
      "id": 5000,
      "label": "seminoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7832,
        20017
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4440",
          "GARD:0023322",
          "ICD9:186.9",
          "ICDO:9061/3",
          "MEDGEN:11371",
          "MESH:D018239",
          "NCIT:C9309",
          "ONCOTREE:SEM",
          "SCTID:443675005",
          "UMLS:C0036631"
        ],
        "synonyms": [
          "seminoma",
          "seminoma, malignant",
          "seminoma, pure"
        ],
        "definition": "A radiosensitive malignant germ cell tumor found in the testis (especially undescended), and extragonadal sites (anterior mediastinum and pineal gland). It is characterized by the presence of uniform cells with clear or dense cytoplasm which contains glycogen, and by a large nucleus which contains one or more nucleoli. The neoplastic germ cells form aggregates separated by fibrous septa. The fibrous septa contain chronic inflammatory cells, mainly lymphocytes."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003001"
    },
    {
      "id": 5424,
      "label": "malignant testicular germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7111,
        7832,
        11294
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5556",
          "GARD:0023539",
          "ICD9:186.9",
          "MEDGEN:163616",
          "NCIT:C9063",
          "SCTID:713646001",
          "UMLS:C0855197"
        ],
        "synonyms": [
          "testicular cancer",
          "malignant germ cell neoplasm of testis",
          "malignant germ cell neoplasm of the testis",
          "malignant germ cell tumor of testis",
          "malignant germ cell tumor of the testis",
          "malignant germ cell tumour of testis",
          "malignant germ cell tumour of the testis",
          "malignant testicular germ cell neoplasm",
          "malignant testicular germ cell tumor",
          "testicular ca. (no germ/tropho.)",
          "testicular cancer (excluding germ cell or trophoblastic cancer)",
          "testicular germ cell cancer",
          "testicular malignant germ cell cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant tumor predominantly affecting young men and often associated with cryptorchidism. Seminoma is the most frequently seen malignant testicular germ cell tumor, followed by embryonal carcinoma and yolk sac tumor."
      },
      "child_count": 18,
      "reference_id": "MONDO:0003510"
    }
  ],
  "children": [
    {
      "id": 5830,
      "label": "tubular variant testicular seminoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5554
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6706",
          "GARD:0023757",
          "MEDGEN:308259",
          "NCIT:C40959",
          "UMLS:C1515294"
        ],
        "synonyms": [
          "testicular seminoma, tubular variant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A morphologic variant of testicular seminoma characterized by the presence of seminoma cells arranged in tubular patterns and few lymphocytes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003973"
    },
    {
      "id": 5992,
      "label": "cribriform variant testicular seminoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5554
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7269",
          "GARD:0023860",
          "MEDGEN:308258",
          "NCIT:C40957",
          "UMLS:C1515292"
        ],
        "synonyms": [
          "testicular seminoma, cribriform variant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A morphologic variant of testicular seminoma characterized by the presence of seminoma cells arranged in cribriform patterns and few lymphocytes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004168"
    },
    {
      "id": 6340,
      "label": "pseudoglandular variant testicular seminoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5554
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8358",
          "GARD:0024056",
          "MEDGEN:273633",
          "NCIT:C40958",
          "UMLS:C1515293"
        ],
        "synonyms": [
          "testicular seminoma, pseudoglandular variant"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A morphologic variant of testicular seminoma characterized by the presence of seminoma cells arranged in pseudoglandular patterns and few lymphocytes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004541"
    },
    {
      "id": 19964,
      "label": "spermatocytic seminoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5554
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5834",
          "DOID:7891",
          "GARD:0016921",
          "ICDO:9063/3",
          "MEDGEN:83159",
          "NCIT:C39921",
          "Orphanet:99865",
          "UMLS:C0334517"
        ],
        "synonyms": [
          "spermatocytic seminoma",
          "testicular spermatocytic seminoma",
          "spermatocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare variant of seminoma characterized by the presence of three cell types: round cells with eosinophilic cytoplasm, small cells with dark nucleus and a small amount of cytoplasm, and mono-or multinucleated giant cells. The neoplastic cells are not cohesive. There is an edematous stroma present; lymphocytic infiltrates are rarely seen. Most patients are older males."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020513"
    }
  ],
  "roots": [
    {
      "id": 4887,
      "label": "testicular pure germ cell tumor"
    },
    {
      "id": 5000,
      "label": "seminoma"
    },
    {
      "id": 5424,
      "label": "malignant testicular germ cell tumor"
    }
  ]
}