{
  "id": 5617,
  "label": "malignant testicular Leydig cell tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003737",
  "properties": {
    "xrefs": [
      "DOID:6021",
      "GARD:0023641",
      "MEDGEN:271769",
      "NCIT:C39942",
      "UMLS:C1515288"
    ],
    "synonyms": [
      "testicular Leydig cell tumor, malignant"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A Leydig cell tumor characterized by a large size, cellular atypia, high mitotic activity, vascular invasion and necrotic changes. The prognosis is usually poor."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 2876,
      "label": "malignant Leydig cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4279,
        7810
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050616",
          "ICDO:8650/3",
          "MEDGEN:83143",
          "NCIT:C4213",
          "UMLS:C0334410"
        ],
        "synonyms": [
          "Leydig cell cancer",
          "Leydig cell tumor, malignant",
          "cancer of Leydig cell",
          "malignant Leydig cell neoplasm",
          "malignant interstitial cell neoplasm",
          "malignant neoplasm of Leydig cell",
          "malignant interstitial cell tumor",
          "malignant interstitial cell tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A Leydig cell tumor characterized by large tumor size, the presence of cytologic atypia, increased mitotic activity, necrosis, and vascular invasion. Approximately 10% of the testicular Leydig cell tumors show malignant characteristics and metastasize. Leydig cell tumors of the ovary follow a benign clinical course."
      },
      "child_count": 2,
      "reference_id": "MONDO:0000377"
    },
    {
      "id": 5101,
      "label": "testicular Leydig cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5102,
        7810
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4756",
          "GARD:0023375",
          "MEDGEN:163584",
          "NCIT:C6356",
          "SCTID:67871000119105",
          "UMLS:C0863027"
        ],
        "synonyms": [
          "Leydig cell neoplasm of testis",
          "Leydig cell neoplasm of the testis",
          "Leydig cell tumor of testis",
          "Leydig cell tumour of testis",
          "testicular Leydig cell neoplasm",
          "testicular Leydig cell tumor",
          "testis Leydig cell tumor",
          "testis Leydig cell tumour",
          "Leydig cell tumor of the testis",
          "Leydig cell tumour of the testis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A sex cord-stromal tumor that arises from the testis and is characterized by the presence of cells that resemble the successive stages of development of Leydig cells. It usually presents as a painless testicular mass. Gynecomastia is present in approximately thirty percent of the cases. Libido may be decreased. In children, precocious puberty may be present. A minority of cases exhibit malignant characteristics."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003124"
    },
    {
      "id": 7111,
      "label": "testicular cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7450,
        20517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2998",
          "EFO:0005088",
          "ICD10CM:C62",
          "ICD9:186",
          "ICD9:186.9",
          "MEDGEN:56313",
          "MESH:D013736",
          "NCIT:C7251",
          "SCTID:363449006",
          "UMLS:C0153594"
        ],
        "synonyms": [
          "testicular tumor",
          "testicular tumour",
          "testis neoplasm",
          "cancer of testis",
          "malignant neoplasm of testis",
          "malignant neoplasm of the testis",
          "malignant testicular neoplasm",
          "malignant testicular tumor",
          "malignant testicular tumour",
          "malignant testis neoplasm",
          "malignant tumor of testis",
          "malignant tumor of the testis",
          "malignant tumour of testis",
          "malignant tumour of the testis",
          "testis cancer",
          "paediatric testicular neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A primary or metastatic malignant neoplasm that affects the testis. Representative examples include seminoma, embryonal carcinoma, sarcoma, leukemia, and lymphoma."
      },
      "child_count": 22,
      "reference_id": "MONDO:0005447"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 2876,
      "label": "malignant Leydig cell tumor"
    },
    {
      "id": 5101,
      "label": "testicular Leydig cell tumor"
    },
    {
      "id": 7111,
      "label": "testicular cancer"
    }
  ]
}