{
  "id": 5618,
  "label": "selective IgE deficiency disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003738",
  "properties": {
    "xrefs": [
      "DOID:6024",
      "GARD:0023642",
      "ICD9:279.03",
      "MEDGEN:96020",
      "NCIT:C27143",
      "SCTID:234540007",
      "UMLS:C0398694"
    ],
    "synonyms": [
      "selective IgE immunodeficiency"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A rare dysgammaglobulinemia characterized by low or undetectable serum levels of immunoglobulin class E (IgE). It is an uncommon primary antibody deficiency. It is most likely an inherited immunodeficiency. It may be caused by decreased or inefficient class-switching from progenitor B cells without any corresponding decreases in the other isotypes. Most affected persons appear asymptomatic but may show a predisposition to autoimmune and respiratory diseases."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 3570,
      "label": "dysgammaglobulinemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5619
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11702",
          "GARD:0022925",
          "HP:0002961",
          "MEDGEN:41679",
          "MESH:D004406",
          "SCTID:123782009",
          "UMLS:C0013374"
        ],
        "synonyms": [
          "dysgammaglobulinemia",
          "dysgammaglobulinemia (disease)",
          "dysgammaglobulinemia (finding)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An immunologic deficiency state characterized by selective deficiencies of one or more, but not all, classes of immunoglobulins."
      },
      "child_count": 4,
      "reference_id": "MONDO:0001342"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 3570,
      "label": "dysgammaglobulinemia"
    }
  ]
}