{
  "id": 5619,
  "label": "selective immunoglobulin deficiency disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003739",
  "properties": {
    "xrefs": [
      "DOID:6025",
      "GARD:0023643",
      "MEDGEN:235584",
      "NCIT:C27870",
      "UMLS:C1335942"
    ],
    "synonyms": [
      "selective Immunoglobulin isotype deficiency"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A broad classification of dysgammaglobulinemias characterized by low or undetectable serum levels of one of the five immunoglobulin classes. Deficiencies of immunoglobulins present variably according to isotype. Selective deficiencies may be caused by decreased or inefficient production from progenitor B cells without any corresponding decreases in the other isotypes. The clinical course and prognosis is dependent upon the severity of the selective deficiency and associated morbidity."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 4332,
      "label": "B cell deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5658,
        6569,
        20334
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2115",
          "GARD:0023084",
          "ICD9:279.03",
          "MEDGEN:340780",
          "NCIT:C4799",
          "UMLS:C1855067"
        ],
        "synonyms": [
          "B-cell deficiency",
          "deficiency of humoral immunity",
          "immunoglobulin heavy chain deficiency",
          "immunoglobulin heavy chain deletion"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A broad classification of disorders where circulating numbers of B lymphocytes are decreased or ineffective. Complement components and the production of antibodies may also be deficient."
      },
      "child_count": 15,
      "reference_id": "MONDO:0002211"
    }
  ],
  "children": [
    {
      "id": 3570,
      "label": "dysgammaglobulinemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5619
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11702",
          "GARD:0022925",
          "HP:0002961",
          "MEDGEN:41679",
          "MESH:D004406",
          "SCTID:123782009",
          "UMLS:C0013374"
        ],
        "synonyms": [
          "dysgammaglobulinemia",
          "dysgammaglobulinemia (disease)",
          "dysgammaglobulinemia (finding)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An immunologic deficiency state characterized by selective deficiencies of one or more, but not all, classes of immunoglobulins."
      },
      "child_count": 4,
      "reference_id": "MONDO:0001342"
    },
    {
      "id": 5990,
      "label": "selective IgD deficiency disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5619
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7263",
          "GARD:0023858",
          "ICD9:279.03",
          "MEDGEN:96021",
          "NCIT:C27144",
          "SCTID:234541006",
          "UMLS:C0398695"
        ],
        "synonyms": [
          "selective IgD immunodeficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare dysgammaglobulinemia characterized by low or undetectable serum levels of immunoglobulin class D (IgD). It is an uncommon primary antibody deficiency. It is most likely an inherited immunodeficiency. It may be caused by decreased or inefficient production of IgD from progenitor B cells without any corresponding decreases in the other isotypes. Most affected persons are asymptomatic and do not appear to be at increased risk for infection."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004165"
    }
  ],
  "roots": [
    {
      "id": 4332,
      "label": "B cell deficiency"
    }
  ]
}