{
  "id": 5624,
  "label": "spindle cell intraocular melanoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003744",
  "properties": {
    "xrefs": [
      "DOID:6037",
      "GARD:0023646",
      "MEDGEN:76015",
      "NCIT:C7986",
      "UMLS:C0279687"
    ],
    "synonyms": [
      "spindle cell melanoma of the uvea",
      "spindle cell melanoma of uvea",
      "spindle cell uveal melanoma",
      "uveal spindle cell melanoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002022",
        "name": "disorder of orbital region"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      }
    ],
    "definition": "A melanoma arising from the choroid, ciliary body, or the iris. It is characterized by the presence of spindle-shaped melanocytes."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 7943,
      "label": "spindle cell melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6832,
        20077
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3162",
          "EFO:1000546",
          "ICDO:8772/3",
          "MEDGEN:83147",
          "NCIT:C4237",
          "SCTID:403923002",
          "UMLS:C0334444"
        ],
        "synonyms": [
          "malignant spindle cell melanoma",
          "spindle cell malignant melanoma",
          "spindle cell melanoma"
        ],
        "definition": "A melanoma characterized by the presence of malignant spindle-shaped melanocytes."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006427"
    },
    {
      "id": 7983,
      "label": "uveal melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4710,
        7858
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6039",
          "EFO:1000616",
          "GARD:0008621",
          "MEDGEN:65077",
          "MESH:C536494",
          "MedDRA:10061252",
          "NCIT:C7712",
          "OMIM:155720",
          "ONCOTREE:UM",
          "Orphanet:39044",
          "UMLS:C0220633"
        ],
        "synonyms": [
          "intraocular melanoma",
          "melanoma (disease) of uvea",
          "melanoma of the uvea",
          "melanoma of uvea",
          "melanoma, uveal, malignant",
          "uvea melanoma",
          "uvea melanoma (disease)",
          "uveal melanoma",
          "iris melanoma",
          "choroidal melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A melanoma derived from melanocytes of the uveal tract. It is the most common primary intraocular tumor in the United States and Western Europe. Similar to melanoma of the skin, it is rare in Africa and Asia. Diagnostic procedures include ophthalmoscopic exam, fluorescein angiography and ultrasound. Treatment includes: surgical excision of the eye, iridocyclectomy and tumor resection. Recent treatments also include radiotherapy or photo coagulation. Classification of uveal melanomas recognizes four cell types within these tumors: epithelioid, intermediate, mixed cell, and spindle cell types. The spindle cell type uveal melanomas are further sub-classified as spindle cell type A and spindle cell type B."
      },
      "child_count": 16,
      "reference_id": "MONDO:0006486"
    },
    {
      "id": 20076,
      "label": "malignant spindle cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        20077
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:90746",
          "NCIT:C27091",
          "UMLS:C0334230"
        ],
        "synonyms": [
          "malignant spindle cell neoplasm",
          "malignant spindle cell tumor",
          "malignant spindle cell tumour",
          "spindle cell cancer"
        ],
        "definition": "A malignant neoplasm characterized by the presence of atypical spindle cells."
      },
      "child_count": 8,
      "reference_id": "MONDO:0020663"
    }
  ],
  "children": [
    {
      "id": 5625,
      "label": "choroid spindle cell melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5624,
        5741
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6041",
          "GARD:0023647",
          "MEDGEN:272477",
          "NCIT:C6099",
          "UMLS:C1333027"
        ],
        "synonyms": [
          "optic choroid spindle cell melanoma",
          "spindle cell melanoma of choroid",
          "spindle cell melanoma of optic choroid",
          "spindle cell melanoma of the choroid"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A spindle cell melanoma that involves the optic choroid."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003745"
    },
    {
      "id": 6010,
      "label": "iris spindle cell melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5624,
        5904
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7328",
          "GARD:0023867",
          "MEDGEN:232672",
          "NCIT:C6098",
          "UMLS:C1334287"
        ],
        "synonyms": [
          "iris spindle cell melanoma",
          "spindle cell melanoma of iris",
          "spindle cell melanoma of the iris"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A spindle cell melanoma that involves the iris."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004188"
    }
  ],
  "roots": [
    {
      "id": 7943,
      "label": "spindle cell melanoma"
    },
    {
      "id": 7983,
      "label": "uveal melanoma"
    },
    {
      "id": 20076,
      "label": "malignant spindle cell neoplasm"
    }
  ]
}