{
  "id": 5637,
  "label": "paraplegia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003757",
  "properties": {
    "xrefs": [
      "DOID:607",
      "EFO:0009679",
      "ICD10CM:G82.2",
      "ICD9:344.1",
      "MEDGEN:45323",
      "MESH:D010264",
      "NCIT:C50687",
      "SCTID:60389000",
      "UMLS:C0030486",
      "icd11.foundation:1212533558"
    ],
    "synonyms": [
      "severe or complete loss of motor function in the lower extremities and lower portions of the trunk"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Complete paralysis of the lower half of the body including both legs, often caused by damage to the spinal cord."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 7990,
      "label": "palsy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000631",
          "ICD10CM:G80-G83",
          "MEDGEN:854494",
          "MESH:D010243",
          "UMLS:C3887651",
          "Wikipedia:Palsy"
        ],
        "synonyms": [
          "Plegia",
          "Plegias"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A general term most often used to describe severe or complete loss of muscle strength due to motor system disease from the level of the cerebral cortex to the muscle fiber. This term may also occasionally refer to a loss of sensory function. (From Adams et al., Principles of Neurology, 6th ed, p45)"
      },
      "child_count": 10,
      "reference_id": "MONDO:0006496"
    }
  ],
  "children": [
    {
      "id": 5634,
      "label": "Brown-Sequard syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        5637
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:606",
          "EFO:1001279",
          "GARD:0027646",
          "ICD10CM:G83.81",
          "MEDGEN:69225",
          "MESH:D018437",
          "NCIT:C84601",
          "SCTID:27982003",
          "UMLS:C0242644"
        ],
        "synonyms": [
          "Hemicord syndrome",
          "Hemiparaplegic syndrome",
          "Hemispinal cord syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Brown-Sequard syndrome is a rare neurological condition that results from an injury or damage to one side of the spinal cord. This condition results in weakness or paralysis on one side of the body (hemiparaplegia) and a loss of sensation on the opposite side (hemianesthesia). Brown-Sequard syndrome most commonly occurs in the the thoracic spine (upper and middle back). There are several causes of Brown-Sequard syndrome, including: a spinal cord tumor, trauma (such as a puncture wound to the neck or back), infectious or inflammatory diseases (tuberculosis or multiple sclerosis), and disk herniation. Treatment for this condition varies depending on the underlying cause."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003754"
    },
    {
      "id": 18959,
      "label": "hereditary spastic paraplegia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5637,
        21292,
        24271
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2476",
          "GARD:0006637",
          "ICD10CM:G11.4",
          "ICD9:334.1",
          "MEDGEN:20844",
          "MESH:D015419",
          "MedDRA:10019903",
          "NANDO:1200052",
          "NCIT:C140267",
          "NORD:1238",
          "OMIMPS:303350",
          "Orphanet:685",
          "SCTID:39912006",
          "UMLS:C0037773",
          "icd11.foundation:810807375"
        ],
        "synonyms": [
          "spastic paraplegia",
          "HSP",
          "SPG",
          "Strümpell-Lorrain disease",
          "familial spastic paraplegia",
          "hereditary spastic paraparesis",
          "FSP",
          "familial spastic paraparesis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Hereditary spastic paraplegias (HSP) comprise a genetically and clinically heterogeneous group of neurodegenerative disorders characterized by progressive spasticity and hyperreflexia of the lower limbs."
      },
      "child_count": 135,
      "reference_id": "MONDO:0019064"
    }
  ],
  "roots": [
    {
      "id": 7990,
      "label": "palsy"
    }
  ]
}