{ "id": 5658, "label": "inborn error of immunity", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0003778", "properties": { "xrefs": [ "DOID:612", "GARD:0019813", "MEDGEN:585013", "MESH:D007153", "NANDO:1200320", "NANDO:2100204", "Orphanet:101997", "SCTID:58606001", "UMLS:C0398686" ], "synonyms": [ "IEI", "inborn errors of immunity", "primary immunodeficiency disease", "antibody deficiency syndrome", "antibody deficiency syndromes", "deficiency syndrome, antibody", "deficiency syndrome, immunologic", "deficiency syndrome, immunological", "deficiency syndromes, antibody", "deficiency syndromes, immunologic", "deficiency syndromes, immunological", "immune deficiency disorder", "immunodeficiency syndrome", "immunologic deficiency syndrome", "immunological deficiency syndrome", "immunological deficiency syndromes", "primary immunodeficiency", "syndrome, antibody deficiency", "syndrome, immunologic deficiency", "syndrome, immunological deficiency", "syndromes, antibody deficiency", "syndromes, immunologic deficiency", "syndromes, immunological deficiency" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" } ], "definition": "A disorder in which the immune system is unable to mount an adequate immune response." }, "isLeaf": false, "isRoot": false, "child_count": 40, "parents": [ { "id": 6778, "label": "immune system disorder", "isLeaf": false, "isRoot": false, "parents": [ 29379 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2914", "EFO:0000540", "ICD9:279", "ICD9:279.1", "ICD9:279.10", "ICD9:279.19", "ICD9:279.4", "ICD9:279.49", "ICD9:279.8", "ICD9:279.9", "MEDGEN:5759", "MESH:D007154", "NANDO:1100004", "NANDO:2100202", "NCIT:C3507", "SCTID:414029004", "UMLS:C0021053" ], "synonyms": [ "disease of immune system", "disease or disorder of immune system", "disorder of immune system", "immune disease", "immune disorder", "immune dysfunction", "immune system disease or disorder", "immune system disorder" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" } ], "definition": "A disorder resulting from an abnormality in the immune system." }, "child_count": 47, "reference_id": "MONDO:0005046" } ], "children": [ { "id": 4332, "label": "B cell deficiency", "isLeaf": false, "isRoot": false, "parents": [ 5658, 6569, 20334 ], "type_id": 0, "properties": { "xrefs": [ "DOID:2115", "GARD:0023084", "ICD9:279.03", "MEDGEN:340780", "NCIT:C4799", "UMLS:C1855067" ], "synonyms": [ "B-cell deficiency", "deficiency of humoral immunity", "immunoglobulin heavy chain deficiency", "immunoglobulin heavy chain deletion" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" }, { "ref": "MONDO:0005570", "name": "hematologic disorder" } ], "definition": "A broad classification of disorders where circulating numbers of B lymphocytes are decreased or ineffective. Complement components and the production of antibodies may also be deficient." }, "child_count": 15, "reference_id": "MONDO:0002211" }, { "id": 5701, "label": "complement deficiency", "isLeaf": false, "isRoot": false, "parents": [ 5658, 20334 ], "type_id": 0, "properties": { "xrefs": [ "DOID:626", "ICD9:279.8", "MEDGEN:82898", "NANDO:1200364", "NANDO:2200776", "NCIT:C4691", "Orphanet:459345", "SCTID:24743004", "UMLS:C0272242" ], "synonyms": [ "complement activation disease", "complement deficiency", "disorder of complement activation", "immunodeficiency due to a complement cascade component deficiency" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" } ], "definition": "A genetic deficiency of any of the component of the complement system (including the classical, alternative, and terminal pathway components), that can either be acquired or inherited." }, "child_count": 16, "reference_id": "MONDO:0003832" }, { "id": 7512, "label": "phagocyte bactericidal dysfunction", "isLeaf": false, "isRoot": false, "parents": [ 5658, 6569, 21541 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3262", "EFO:0007433", "GARD:0024253", "MEDGEN:14713", "MESH:D010585", "UMLS:C0031306" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" }, { "ref": "MONDO:0005570", "name": "hematologic disorder" } ], "definition": "Disorders in which phagocytic cells cannot kill ingested bacteria; characterized by frequent recurring infection with formulation of granulomas." }, "child_count": 3, "reference_id": "MONDO:0005910" }, { "id": 10352, "label": "trichohepatoenteric syndrome", "isLeaf": false, "isRoot": false, "parents": [ 5658, 6756, 21247, 25666 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0111414", "GARD:0005258", "MEDGEN:347405", "OMIMPS:222470", "Orphanet:84064", "SCTID:703406006", "UMLS:C1857276", "icd11.foundation:1470910753" ], "synonyms": [ "SD/THE", "Tricho-hepato-enteric syndrome", "Trichohepatoenteric syndrome", "Trichohepatoenteric syndrome type 1", "phenotypic diarrhea", "phenotypic diarrhoea", "syndromic diarrhea", "syndromic diarrhea/Tricho-hepato-enteric syndrome", "syndromic diarrhoea", "Syndromatic diarrhea", "Syndromatic diarrhoea", "THES1" ], "categories": [ { "ref": "MONDO:0002254", "name": "syndromic disease" }, { "ref": "MONDO:0003900", "name": "connective tissue disorder" }, { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0005046", "name": "immune system disorder" } ], "definition": "A severe congenital enteropathy manifesting as intractable diarrhea in the first month of life with failure to thrive and associated with facial dysmorphism, hair abnormalities, and, in some cases, immune disorders and intrauterine growth restriction." }, "child_count": 8, "reference_id": "MONDO:0009105" }, { "id": 10570, "label": "hepatic veno-occlusive disease-immunodeficiency syndrome", "isLeaf": true, "isRoot": false, "parents": [ 5658, 5714, 19328 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0112254", "GARD:0010083", "MEDGEN:344659", "MESH:C537257", "NANDO:1200341", "NANDO:2200714", "OMIM:235550", "Orphanet:79124", "SCTID:724361001", "UMLS:C1856128", "icd11.foundation:712514250" ], "synonyms": [ "VODI syndrome", "VODI", "familial veno-occlusive disease with immunodeficiency", "hepatic veno-occlusive disease with immunodeficiency", "hepatic venoocclusive disease with immunodeficiency", "veno-occlusive disease and immunodeficiency syndrome" ], "categories": [ { "ref": "MONDO:0004335", "name": "digestive system disorder" }, { "ref": "MONDO:0004995", "name": "cardiovascular disorder" }, { "ref": "MONDO:0005046", "name": "immune system disorder" }, { "ref": "MONDO:0005151", "name": "endocrine system disorder" } ], "definition": "Hepatic veno-occlusive disease-immunodeficiency syndrome is characterized by the association of severe hypogammaglobulinemia, combined T and B cell immunodeficiency, absent lymph node germinal centers, absent tissue plasma cells and hepatic veno-occlusive disease." }, "child_count": 0, "reference_id": "MONDO:0009338" }, { "id": 10691, "label": "immunodeficiency with defective T-cell response to interleukin 1", "isLeaf": true, "isRoot": false, "parents": [ 5658, 5714 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0024673", "MEDGEN:340948", "OMIM:243110", "UMLS:C1855735" ], "synonyms": [ "immunodeficiency with defective T-cell response to Interleukin type 1", "immunodeficiency with defective T-cell response to interleukin 1", "Interleukin 1, defective T-cell response to" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" } ] }, "child_count": 0, "reference_id": "MONDO:0009464" }, { "id": 10840, "label": "Say-Barber-Miller syndrome", "isLeaf": true, "isRoot": false, "parents": [ 4370, 5658, 16087 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0000239", "MEDGEN:343258", "MESH:C536618", "OMIM:251240", "Orphanet:3132", "SCTID:721903007", "UMLS:C1855078" ], "synonyms": [ "microcephaly-hypogammaglobulinemia-abnormal immunity syndrome", "Say Barber Miller syndrome", "microcephaly hypogammaglobulinemia abnormal immunity", "microcephaly with chemotactic defect and transient hypogammaglobulinemia" ], "categories": [ { "ref": "MONDO:0002254", "name": "syndromic disease" }, { "ref": "MONDO:0005046", "name": "immune system disorder" } ], "definition": "Say-Barber-Miller syndrome is characterized by the association of unusual facial features, microcephaly, developmental delay, and severe postnatal growth retardation." }, "child_count": 0, "reference_id": "MONDO:0009620" }, { "id": 11255, "label": "familial isolated congenital asplenia", "isLeaf": true, "isRoot": false, "parents": [ 5658, 5714, 20383 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0016944", "MEDGEN:151935", "MESH:C563028", "NANDO:2200775", "OMIM:271400", "Orphanet:101351", "SCTID:726708009", "UMLS:C0685889" ], "synonyms": [ "ICAS", "asplenia, familial", "asplenia, isolated congenital", "hyposplenia, isolated congenital", "splenic hypoplasia" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" } ], "definition": "Familial isolated congenital asplenia is a rare, non-syndromic, potentially life-threatening visceral malformation characterized by the absence of normal spleen function, resulting in a primary immunodeficiency. Typically, the condition manifests with severe, recurrent, overwhelming infections (especially pneumococcal sepsis) in otherwise apparently healthy infants. In adults with no history of severe sepsis in infancy, thrombocytosis may be the presenting sign. Howell-Jolly bodies on blood smears and an absent spleen on abdominal ultrasound examination are highly suggestive associated findings." }, "child_count": 0, "reference_id": "MONDO:0010066" }, { "id": 11419, "label": "X-linked immunoneurologic disorder", "isLeaf": true, "isRoot": false, "parents": [ 2902, 5658, 24270 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0000274", "MEDGEN:341162", "MESH:C536743", "OMIM:300076", "Orphanet:2571", "SCTID:719827008", "UMLS:C1848144", "icd11.foundation:1464555617" ], "synonyms": [ "Woods Black Norbury syndrome", "Woods-Black-Norbury syndrome", "Woods-Black-Norbury syndrome, X-linked dominant", "X-linked immunoneurological disorder", "immunoneurologic disorder, X-linked", "neonatal death immune deficiency" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" }, { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "X-linked immunoneurologic disorder is characterized by immune deficiency and neurological disorders in females, and by neonatal death in males." }, "child_count": 0, "reference_id": "MONDO:0010243" }, { "id": 11465, "label": "ectodermal dysplasia and immune deficiency", "isLeaf": false, "isRoot": false, "parents": [ 5658, 17032 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0081077", "GARD:0009936", "MEDGEN:375786", "MESH:C536181", "NANDO:1200360", "NANDO:2200761", "NCIT:C118844", "OMIMPS:300291", "Orphanet:98813", "SCTID:703525006", "UMLS:C1846006" ], "synonyms": [ "EDA-ID", "HED-ID", "anhidrotic ectodermal dysplasia with immune deficiency", "anhidrotic ectodermal dysplasia with immunodeficiency", "hypohidrotic ectodermal dysplasia with immune deficiency", "hypohidrotic ectodermal dysplasia with immunodeficiency", "Xhm-Ed", "ectodermal dysplasia, anhidrotic, with immune deficiency", "ectodermal dysplasia, hypohidrotic, with immune deficiency", "hyper-IgM immunodeficiency, X-linked, with hypohidrotic ectodermal dysplasia" ], "categories": [ { "ref": "MONDO:0002051", "name": "integumentary system disorder" }, { "ref": "MONDO:0002254", "name": "syndromic disease" }, { "ref": "MONDO:0005046", "name": "immune system disorder" } ] }, "child_count": 4, "reference_id": "MONDO:0010293" }, { "id": 11549, "label": "immunodeficiency 33", "isLeaf": true, "isRoot": false, "parents": [ 5658, 23904 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0112003", "GARD:0012915", "MEDGEN:370376", "MESH:C536289", "MESH:C567070", "OMIM:300584", "OMIM:300636", "Orphanet:319612", "UMLS:C1970879" ], "synonyms": [ "IKBKG X-linked mendelian susceptibility to mycobacterial diseases", "IKBKG invasive pneumococcal disease, recurrent isolated", "IMD33", "IPD2", "X-linked mendelian susceptibility to mycobacterial diseases caused by mutation in IKBKG", "immunodeficiency 33, Mycobacteriosis, X-linked", "immunodeficiency 33, X-linked recessive", "immunodeficiency type 33", "immunodeficiency without anhidrotic ectodermal dysplasia", "immunodeficiency, isolated", "immunodeficiency, pure", "invasive pneumococcal disease, recurrent isolated caused by mutation in IKBKG", "invasive pneumococcal disease, recurrent isolated, 2", "invasive pneumococcal disease, recurrent isolated, type 2", "NEMO deficiency syndrome", "NF-kappa B essential modulator deficiency", "atypical Mycobacteriosis, familial, X-linked 1", "familial X-linked 1 atypical mycobacteriosis" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" } ], "definition": "Any immunodeficiency disease in which the cause of the disease is a mutation in the IKBKG gene." }, "child_count": 0, "reference_id": "MONDO:0010386" }, { "id": 11662, "label": "immunodeficiency 47", "isLeaf": true, "isRoot": false, "parents": [ 5658, 5714 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0112002", "GARD:0024733", "MEDGEN:934786", "OMIM:300972", "Orphanet:692790", "UMLS:C4310819" ], "synonyms": [ "ATP6AP1 primary immunodeficiency disease", "IMD47", "immunodeficiency 47", "immunodeficiency 47, X-linked recessive", "immunodeficiency 47; IMD47", "immunodeficiency type 47", "primary immunodeficiency disease caused by mutation in ATP6AP1", "immunodeficiency and hepatopathy with or without neurologic features" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" } ], "definition": "Any primary immunodeficiency disease in which the cause of the disease is a mutation in the ATP6AP1 gene." }, "child_count": 0, "reference_id": "MONDO:0010504" }, { "id": 11671, "label": "combined immunodeficiency due to moesin deficiency", "isLeaf": true, "isRoot": false, "parents": [ 5658, 16075 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0112001", "GARD:0017939", "MEDGEN:1799546", "OMIM:300988", "Orphanet:504530", "UMLS:C5568123" ], "synonyms": [ "CID due to Moesin deficiency", "IMD50", "MSN-related combined immunodeficiency", "X-linked Moesin-associated immunodeficiency", "immunodeficiency 50", "immunodeficiency type 50", "immunodeficiency 50, X-linked recessive" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" } ] }, "child_count": 0, "reference_id": "MONDO:0010514" }, { "id": 11771, "label": "immunodeficiency, X-linked, with deficiency of 115,000 Dalton surface glycoprotein", "isLeaf": true, "isRoot": false, "parents": [ 5658, 5714 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0024741", "MEDGEN:326624", "MESH:C564120", "OMIM:308220", "UMLS:C1839982" ], "synonyms": [ "immunodeficiency, X-linked, with deficiency of 115,000 Dalton surface glycoprotein", "Gpl115 deficiency" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" } ] }, "child_count": 0, "reference_id": "MONDO:0010625" }, { "id": 11855, "label": "properdin deficiency, X-linked", "isLeaf": true, "isRoot": false, "parents": [ 5658, 5714 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0111768", "GARD:0004513", "ICD9:279.8", "MEDGEN:333322", "MESH:C537241", "NANDO:2200789", "OMIM:312060", "Orphanet:2966", "SCTID:81166004", "UMLS:C1839454" ], "synonyms": [ "properdin deficiency, X-linked", "properdin deficiency, X-linked, X-linked recessive", "CFPD", "PFD", "complement Factor properdin deficiency", "properdin P Factor deficiency", "properdin deficiency, type 1", "properdin deficiency, type 2", "properdin deficiency, type 3" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" } ], "definition": "A rare, hereditary, primary immunodeficiency due to a complement cascade protein anomaly characterized by significantly increased susceptibility to Neisseria species infections. It only affects males, typically presenting with severe or fulminant meningococcal disease." }, "child_count": 0, "reference_id": "MONDO:0010713" }, { "id": 14262, "label": "combined immunodeficiency with faciooculoskeletal anomalies", "isLeaf": true, "isRoot": false, "parents": [ 5658, 16088, 24683 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0017139", "MEDGEN:442377", "MESH:C567641", "OMIM:613328", "Orphanet:221139", "UMLS:C2750068" ], "synonyms": [ "Roifman-Chitayat syndrome", "Roifman-Chitayat syndrome, digenic", "ROIFMAN-Chitayat syndrome", "combined immunodeficiency, Facial Dysmorphism, optic nerve atrophy, skeletal anomalies, and developmental delay" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" } ], "definition": "Combined immunodeficiency with faciooculoskeletal anomalies is an extremely rare combined immunodeficiency disorder characterized by primary immunodeficiency manifesting with repeated bacterial, viral and fungal infections, in association with neurological manifestations (hypotonia, cerebellar ataxia, myoclonic seizures), developmental delay, optic atrophy, facial dysmorphism (high forehead, hypoplastic supraorbital ridges, palpebral edema, hypertelorism, flat nasal bridge, broad nasal root and tip, anteverted nares, thin lower lip overlapped by upper lip, square chin) and skeletal anomalies (short metacarpals/metatarsals with cone-shaped epiphyses, osteopenia)." }, "child_count": 0, "reference_id": "MONDO:0013226" }, { "id": 14604, "label": "recurrent infections associated with rare immunoglobulin isotypes deficiency", "isLeaf": true, "isRoot": false, "parents": [ 5658, 5714 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0017086", "MEDGEN:481454", "MESH:C564131", "NANDO:2200719", "OMIM:614102", "Orphanet:183675", "UMLS:C3279824" ], "synonyms": [ "IgG subclass deficiency with IgA subclass deficiency", "isolated IgG subclass deficiency", "kappa-chain deficiency", "recurrent infections associated with rare immunoglobulin isotypes deficiency", "IGKCD", "IMMUNOGLOBULIN kappa LIGHT chain deficiency" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" } ], "definition": "Deficiencies in immunoglobulin (Ig) isotypes (including: isolated IgG subclass deficiency, IgG subclass deficiency with IgA deficiency and kappa chain deficiency) are primary immunodeficiencies that are often asymptomatic but can be characterized by recurrent, often pyogenic, sinopulmonary infections." }, "child_count": 0, "reference_id": "MONDO:0013576" }, { "id": 14964, "label": "immunodeficiency 28", "isLeaf": true, "isRoot": false, "parents": [ 5658, 5714 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0111995", "GARD:0024963", "MEDGEN:862384", "OMIM:614889", "UMLS:C4013947" ], "synonyms": [ "IFNGR2 primary immunodeficiency disease", "immunodeficiency 28", "immunodeficiency type 28", "primary immunodeficiency disease caused by mutation in IFNGR2", "IMD28", "Ifngr2 deficiency", "immunodeficiency 28, Mycobacteriosis" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" } ], "definition": "Any primary immunodeficiency disease in which the cause of the disease is a mutation in the IFNGR2 gene." }, "child_count": 0, "reference_id": "MONDO:0013953" }, { "id": 15317, "label": "autosomal recessive primary immunodeficiency with defective spontaneous natural killer cell cytotoxicity", "isLeaf": true, "isRoot": false, "parents": [ 5658, 5714 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0111941", "GARD:0017732", "MEDGEN:816672", "OMIM:615707", "Orphanet:437552", "UMLS:C3810342" ], "synonyms": [ "CD16 deficiency", "autosomal recessive primary immunodeficiency with defective spontaneous NK cell cytotoxicity", "immunodeficiency type 20", "IMD20", "immunodeficiency 20" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" } ] }, "child_count": 0, "reference_id": "MONDO:0014313" }, { "id": 15490, "label": "immunodeficiency 37", "isLeaf": false, "isRoot": false, "parents": [ 5658, 5714 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0111939", "GARD:0024994", "MEDGEN:863632", "OMIM:616098", "UMLS:C4015195" ], "synonyms": [ "BCL10 primary immunodeficiency disease", "combined immunodeficiency due to BCL10 deficiency", "immunodeficiency 37", "immunodeficiency type 37", "primary immunodeficiency disease caused by mutation in BCL10", "IMD37" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" } ], "definition": "Any primary immunodeficiency disease in which the cause of the disease is a mutation in the BCL10 gene." }, "child_count": 2, "reference_id": "MONDO:0014491" }, { "id": 15595, "label": "immunodeficiency 39", "isLeaf": true, "isRoot": false, "parents": [ 5658, 5714 ], "type_id": 0, "properties": { "xrefs": [ "DOID:0111969", "GARD:0025005", "ICD10CM:D84.8", "MEDGEN:904167", "OMIM:616345", "Orphanet:574918", "SCTID:1269234000", "UMLS:C4225358" ], "synonyms": [ "IRF7 primary immunodeficiency disease", "immunodeficiency 39", "immunodeficiency type 39", "predisposition to severe viral infection due to IRF7 deficiency", "primary immunodeficiency disease caused by mutation in IRF7", "IMD39" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" } ], "definition": "Any primary immunodeficiency disease in which the cause of the disease is a mutation in the IRF7 gene." }, "child_count": 0, "reference_id": "MONDO:0014597" }, { "id": 15641, "label": "BENTA disease", "isLeaf": true, "isRoot": false, "parents": [ 5658, 5714 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0013339", "MEDGEN:1641265", "OMIM:616452", "Orphanet:464336", "UMLS:C4551967" ], "synonyms": [ "B-cell expansion with NF-kB and T-cell anergy disease", "B-cell expansion with NFKB and T-cell anergy", "BENTA" ], "categories": [ { "ref": "MONDO:0005046", "name": "immune system disorder" } ], "definition": "BENTA disease (B cell Expansion with N F-N:B and T cell Anergy) is a very rare congenital immune deficiency disorder. The main symptoms include spleen enlargement (splenomegalia) and frequent ear, sinus, and lung infections early in life. Some patients can present with molluscum contagiosum or chronic Epstein-Barr virus (EBV) infection. Blood exams show alterations of several immune cells with very high numbers of polyclonal B cell lymphocytos (above 2200/N