{
  "id": 5659,
  "label": "T-cell immunodeficiency",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003780",
  "properties": {
    "xrefs": [
      "DOID:613",
      "GARD:0005107",
      "MEDGEN:226894",
      "NCIT:C27145",
      "SCTID:402792003",
      "UMLS:C1274233"
    ],
    "synonyms": [
      "T-cell immunodeficiency",
      "T-lymphocyte deficiency (finding)",
      "T-lymphocyte immunodeficiency",
      "T lymphocyte deficiency"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "A broad classification of disorders that affect the cell-mediated aspect of the immune response. Circulating numbers of T lymphocytes are decreased or ineffective."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 20334,
      "label": "immunodeficiency disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD9:279.3",
          "MEDGEN:7034",
          "NANDO:2100204",
          "NCIT:C3131",
          "OMIMPS:300755",
          "SCTID:234532001",
          "UMLS:C0021051"
        ],
        "synonyms": [
          "immuno-deficiency",
          "immunodeficiency",
          "immunodeficiency disorder",
          "immunodeficiency syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "Disease in which there is a deficiency or defect in the mechanisms of immunity, either cellular or humoral."
      },
      "child_count": 190,
      "reference_id": "MONDO:0021094"
    }
  ],
  "children": [
    {
      "id": 3462,
      "label": "congenital T-cell immunodeficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5659
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11200",
          "GARD:0027570",
          "MEDGEN:232099",
          "NCIT:C27872",
          "UMLS:C1333147"
        ],
        "synonyms": [
          "congenital T-cell immunodeficiency",
          "T cell deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A broad classification of inherited disorders presenting at birth that affect the cell-mediated aspect of the immune response. Circulating numbers of T lymphocytes are decreased or ineffective."
      },
      "child_count": 2,
      "reference_id": "MONDO:0001222"
    },
    {
      "id": 7423,
      "label": "idiopathic CD4-positive T-lymphocytopenia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5659,
        5662,
        24405
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3109",
          "GARD:0024233",
          "MEDGEN:64647",
          "MESH:D018344",
          "NCIT:C84780",
          "UMLS:C0206744"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare immunodeficiency syndrome characterized by the decrease of the CD4-positive lymphocytes below 300 per cubic millimeter in the absence of identifiable immunodeficiency causes. Patients with this syndrome are at an increased risk of opportunistic infections."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005807"
    },
    {
      "id": 13327,
      "label": "AIDS",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5659,
        6835
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:635",
          "EFO:0000765",
          "MEDGEN:99",
          "MESH:D000163",
          "NANDO:2100212",
          "NANDO:2200809",
          "NCIT:C2851",
          "SCTID:62479008",
          "UMLS:C0001175"
        ],
        "synonyms": [
          "AIDS",
          "AIDS, acquired immunodeficiency syndrome",
          "acquired immune deficiency",
          "acquired immunodeficiency disease",
          "acquired immunodeficiency syndrome, AIDS",
          "acquired immunodeficiency syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A syndrome resulting from the acquired deficiency of cellular immunity caused by the human immunodeficiency virus (HIV). It is characterized by the reduction of the Helper T-lymphocytes in the peripheral blood and the lymph nodes. Symptoms include generalized lymphadenopathy, fever, weight loss, and chronic diarrhea. Patients with AIDS are especially susceptible to opportunistic infections (usually pneumocystis carinii pneumonia, cytomegalovirus (CMV) infections, tuberculosis, candida infections, and cryptococcosis), and the development of malignant neoplasms (usually non-Hodgkin lymphoma and Kaposi sarcoma). The human immunodeficiency virus is transmitted through sexual contact, sharing of contaminated needles, or transfusion of contaminated blood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012268"
    }
  ],
  "roots": [
    {
      "id": 20334,
      "label": "immunodeficiency disease"
    }
  ]
}