{
  "id": 5668,
  "label": "hereditary papillary renal cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003789",
  "properties": {
    "xrefs": [
      "DOID:6163",
      "GARD:0013157",
      "MEDGEN:163907",
      "NCIT:C9222",
      "OMIM:605074",
      "Orphanet:47044",
      "SCTID:715561008",
      "UMLS:C0879257"
    ],
    "synonyms": [
      "familial renal papillary carcinoma",
      "hereditary kidney papillary carcinoma",
      "hereditary papillary carcinoma of kidney",
      "hereditary papillary carcinoma of the kidney",
      "hereditary papillary renal carcinoma",
      "hereditary papillary renal cell cancer",
      "hereditary papillary renal cell carcinoma",
      "renal cell carcinoma, papillary",
      "renal cell carcinoma, papillary, 1, familial and somatic"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "A familial carcinoma inherited in an autosomal dominant trait. It is characterized by the development of multiple, bilateral papillary renal cell carcinomas. The carcinomas range from microscopic lesions to clinically symptomatic tumors. It is associated with activating mutations of the MET oncogene."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 5006,
      "label": "hereditary renal cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7199,
        23932
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4455",
          "GARD:0023326",
          "MEDGEN:392857",
          "MESH:C536851",
          "NCIT:C39789",
          "SCTID:717736007",
          "UMLS:C2608055"
        ],
        "synonyms": [
          "hereditary renal cell cancer",
          "hereditary renal cell carcinoma",
          "hereditary renal cell carcinoma (disease)",
          "familial renal carcinoma",
          "hereditary renal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "An instance of renal cell carcinoma (disease) that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 14,
      "reference_id": "MONDO:0003008"
    },
    {
      "id": 18097,
      "label": "papillary renal cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4583,
        7199
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4465",
          "EFO:0000640",
          "GARD:0009572",
          "MEDGEN:266300",
          "NCIT:C6975",
          "ONCOTREE:PRCC",
          "Orphanet:319298",
          "SCTID:733608000",
          "UMLS:C1306837"
        ],
        "synonyms": [
          "HPRCC",
          "chromophil carcinoma of kidney",
          "chromophil carcinoma of the kidney",
          "chromophil renal cell carcinoma",
          "papillary (chromophil) renal cell carcinoma",
          "papillary renal cell adenocarcinoma",
          "papillary renal cell cancer",
          "papillary renal cell carcinoma",
          "renal cell carcinoma, papillary, type 1",
          "RCCP",
          "RCCP1",
          "chromophil RCC",
          "papillary renal carcinoma, malignant - (subtype)",
          "papillary renal cell carcinoma, bilateral - (subtype)",
          "papillary renal cell carcinoma, familial - (subtype)",
          "papillary renal cell carcinoma, multiple - (subtype)",
          "papillary renal cell carcinoma, sporadic - (subtype)",
          "renal adenocarcinoma",
          "renal cell carcinoma, papillary, 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "A rare subtype of renal cell carcinoma, arising from the renal tubular epithelium and showing a papillary growth pattern, which typically manifests with hematuria, flank pain, palpable abdominal mass or nonspecific symptoms, such as fatigue, weight loss or fever. Symptoms related to metastatic spread, such as bone pain or persistent cough, are frequently associated since early diagnosis is not common. It is typically multifocal, bilateral, and in most cases sporadic, although different hereditary syndromes, such as Hereditary leiomyoma renal cell carcinoma, Birt-Hogg-DubC) syndrome and Tuberous sclerosis, may predispose to the development of papillary renal cell carcinoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0017884"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 5006,
      "label": "hereditary renal cell carcinoma"
    },
    {
      "id": 18097,
      "label": "papillary renal cell carcinoma"
    }
  ]
}