{
  "id": 5672,
  "label": "ovarian small cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003795",
  "properties": {
    "xrefs": [
      "DOID:6179",
      "EFO:1000431",
      "GARD:0010411",
      "MEDGEN:389177",
      "NCIT:C27390",
      "ONCOTREE:SCCO",
      "Orphanet:370396",
      "UMLS:C2212006"
    ],
    "synonyms": [
      "SCCO",
      "ovarian small cell NEC",
      "ovarian small cell cancer",
      "ovarian small cell carcinoma",
      "ovarian small cell neuroendocrine carcinoma",
      "ovary small cell carcinoma",
      "small cell carcinoma of ovary",
      "small cell carcinoma of the ovary",
      "small cell ovarian carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A carcinoma that arises from the ovary and is characterized by the presence of small malignant cells. It includes small cell carcinoma, hypercalcemic type and small cell carcinoma, pulmonary type."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 2894,
      "label": "small cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050685",
          "EFO:0008524",
          "GARD:0022765",
          "ICDO:8041/3",
          "ICDO:8042/3",
          "MEDGEN:90748",
          "MESH:D018288",
          "NCIT:C3915",
          "NCIT:C4099",
          "SCTID:11010461000119101",
          "UMLS:C0334239"
        ],
        "synonyms": [
          "oat cell cancer",
          "oat cell carcinoma",
          "small cell NEC",
          "small cell cancer",
          "small cell car. (extrapulmonary)",
          "small cell carcinoma",
          "small cell carcinoma (extrapulmonary)",
          "small cell neuroendocrine carcinoma",
          "intermediate cell small cell carcinoma",
          "small cell carcinoma - intermediate cell",
          "small cell carcinoma, intermediate cell",
          "small cell carcinoma, intermediate cell (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine carcinoma composed of small malignant cells which are often said to resemble \"oat cells\" under the microscope. Small cell carcinoma most often affects the lungs. Clinically, this is often a rapidly growing cancer that spreads to distant sites early."
      },
      "child_count": 18,
      "reference_id": "MONDO:0000402"
    },
    {
      "id": 4561,
      "label": "ovarian neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        9481,
        19314,
        20310
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3002",
          "GARD:0023145",
          "MEDGEN:277459",
          "NCIT:C5237",
          "UMLS:C1335172"
        ],
        "synonyms": [
          "neuroendocrine neoplasm of ovary",
          "neuroendocrine neoplasm of the ovary",
          "neuroendocrine tumour of ovary",
          "ovarian neuroendocrine neoplasm",
          "ovary NET",
          "ovary neuroendocrine neoplasm",
          "ovary neuroendocrine tumor",
          "ovary neuroendocrine tumor, well differentiated, low or intermediate grade",
          "ovary neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An epithelial neoplasm with neuroendocrine differentiation that arises from the ovary. It includes carcinoid tumor, small cell carcinoma pulmonary type, and large cell neuroendocrine carcinoma."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002481"
    },
    {
      "id": 6864,
      "label": "ovarian carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18447
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4001",
          "EFO:0001075",
          "GARD:0024154",
          "MEDGEN:1648335",
          "NCIT:C4908",
          "UMLS:C4721610"
        ],
        "synonyms": [
          "ovarian cancer",
          "ovarian epithelial cancer",
          "carcinoma of ovary",
          "carcinoma of the ovary",
          "epithelial ovarian cancer",
          "ovarian carcinoma",
          "ovary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm originating from the surface ovarian epithelium. It accounts for the greatest number of deaths from malignancies of the female genital tract and is the fifth leading cause of cancer fatalities in women. It is predominantly a disease of older white women of northern European extraction, but it is seen in all ages and ethnic groups. Adenocarcinomas constitute the vast majority of ovarian carcinomas. The pattern of metastatic spread in ovarian carcinoma is similar regardless of the microscopic type. The most common sites of involvement are the contralateral ovary, peritoneal cavity, para-aortic and pelvic lymph nodes, and liver. Lung and pleura are the most common sites of extra-abdominal spread. The primary form of therapy is surgical. The overall prognosis of ovarian carcinoma remains poor, a direct result of its rapid growth rate and the lack of early symptoms. --2002"
      },
      "child_count": 9,
      "reference_id": "MONDO:0005140"
    }
  ],
  "children": [
    {
      "id": 6134,
      "label": "pulmonary type ovarian small cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5672
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7650",
          "GARD:0023931",
          "MEDGEN:309517",
          "NCIT:C40440",
          "UMLS:C1518737"
        ],
        "synonyms": [
          "ovarian small cell carcinoma, pulmonary type"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An aggressive small cell neuroendocrine carcinoma that arises from the ovary. Morphologically, it resembles the small cell carcinoma that arises from the lung."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004318"
    },
    {
      "id": 6135,
      "label": "hypercalcemic type ovarian small cell carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5672
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7651",
          "GARD:0023932",
          "MEDGEN:275294",
          "NCIT:C40439",
          "UMLS:C1518736"
        ],
        "synonyms": [
          "SCCOHT",
          "ovarian small cell carcinoma, hypercalcemic type"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An undifferentiated small cell carcinoma that arises from the ovary and is associated with hypercalcemia. Electron microscopic studies show neurosecretory granules are either absent or, when present, are in small numbers."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004319"
    }
  ],
  "roots": [
    {
      "id": 2894,
      "label": "small cell carcinoma"
    },
    {
      "id": 4561,
      "label": "ovarian neuroendocrine neoplasm"
    },
    {
      "id": 6864,
      "label": "ovarian carcinoma"
    }
  ]
}