{
  "id": 5678,
  "label": "aortic valve disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003803",
  "properties": {
    "xrefs": [
      "DOID:62",
      "EFO:0009531",
      "ICD9:395",
      "ICD9:424.1",
      "MEDGEN:226776",
      "NCIT:C78650",
      "UMLS:C1260873",
      "icd11.foundation:1609206873"
    ],
    "synonyms": [
      "aortic valve disease",
      "aortic valve disease or disorder",
      "aortic valve disorder",
      "disease of aortic valve",
      "disease or disorder of aortic valve",
      "disorder of aortic valve"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "A disease involving the aortic valve."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 4883,
      "label": "heart valve disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6967
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4079",
          "EFO:0009551",
          "ICD9:424.99",
          "MEDGEN:5463",
          "MESH:D006349",
          "NANDO:2100105",
          "NCIT:C45525",
          "SCTID:368009",
          "UMLS:C0018824",
          "icd11.foundation:1121431779"
        ],
        "synonyms": [
          "cardial valve disease",
          "cardial valve disease or disorder",
          "disease of cardial valve",
          "disease or disorder of cardial valve",
          "disorder of cardial valve",
          "disorder of heart valve",
          "heart valve disorder",
          "valvular heart disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A disease involving the cardial valve."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002869"
    },
    {
      "id": 7210,
      "label": "aortic disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2933
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:520",
          "EFO:0005775",
          "ICD9:447.9",
          "MEDGEN:1618",
          "MESH:D001018",
          "NCIT:C101253",
          "SCTID:47040006",
          "UMLS:C0003493"
        ],
        "synonyms": [
          "aorta disease",
          "aorta disease or disorder",
          "disease of aorta",
          "disease or disorder of aorta",
          "disorder of aorta"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Pathology involving the thoracic, thoracoabdominal, or abdominal aorta (including aneurysms). (ACC)"
      },
      "child_count": 17,
      "reference_id": "MONDO:0005561"
    },
    {
      "id": 23501,
      "label": "cardiac ventricle disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6967
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:736361",
          "SCTID:415991003",
          "UMLS:C1562298"
        ],
        "synonyms": [
          "cardiac ventricle disease",
          "cardiac ventricle disease or disorder",
          "disease of cardiac ventricle",
          "disease or disorder of cardiac ventricle",
          "disorder of cardiac ventricle"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A disease or disorder that involves the cardiac ventricle."
      },
      "child_count": 2,
      "reference_id": "MONDO:0045001"
    }
  ],
  "children": [
    {
      "id": 7122,
      "label": "aortic valve calcification",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5678
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0005239",
          "HP:0004380",
          "MEDGEN:140899",
          "SCTID:250978003",
          "UMLS:C0428791"
        ],
        "synonyms": [
          "aortic valve calcification",
          "aortic valve calcification (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Calcification of the aortic valve"
      },
      "child_count": 0,
      "reference_id": "MONDO:0005463"
    },
    {
      "id": 7284,
      "label": "aortic valve insufficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5678,
        20084
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:57",
          "EFO:0007148",
          "ICD10CM:I06.1",
          "ICD9:395.1",
          "ICD9:396.3",
          "MEDGEN:8153",
          "MESH:D001022",
          "NANDO:2200307",
          "NCIT:C51223",
          "SCTID:78031003",
          "UMLS:C0003504",
          "icd11.foundation:1548485475"
        ],
        "synonyms": [
          "aortic insufficiency",
          "rheumatic aortic insufficiency",
          "rheumatic aortic regurgitation"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Dysfunction of the aortic valve characterized by incomplete valve closure."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005648"
    },
    {
      "id": 8127,
      "label": "aortic valve prolapse",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5678
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5232",
          "MEDGEN:1619",
          "MESH:D001023",
          "MedDRA:10057454",
          "UMLS:C0003505"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "The downward displacement of the cuspal or pointed end of the trileaflet aortic valve causing misalignment of the cusps. Severe valve distortion can cause leakage and allow the backflow of blood from the ascending aorta back into the left ventricle, leading to aortic regurgitation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006655"
    },
    {
      "id": 8600,
      "label": "familial bicuspid aortic valve",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5678,
        20383,
        24272
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080332",
          "GARD:0017670",
          "MEDGEN:1670287",
          "OMIMPS:109730",
          "Orphanet:402075",
          "UMLS:C4749284"
        ],
        "synonyms": [
          "familial BAV",
          "AOVD1",
          "aortic valve disease 1",
          "aortic valve disease type 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A rare, genetic, aortic malformation defined as a presence of abnormal two-leaflet aortic valve in at least 2 first-degree relatives. It is frequently asymptomatic or may be associated with progressive aortic valve disease (aortic regurgitation and/or aortic stenosis, typically due to valve calcification) and a concomitant aortopathy (i.e. aortic dilation, aortic aneurysm and/or dissection)."
      },
      "child_count": 9,
      "reference_id": "MONDO:0007194"
    },
    {
      "id": 23105,
      "label": "aortic valve stenosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5678,
        20383
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1712",
          "HP:0001650",
          "ICD10CM:I06.0",
          "ICD9:395.0",
          "MEDGEN:1621",
          "MESH:D001024",
          "NANDO:2200306",
          "NCIT:C50462",
          "SCTID:60573004",
          "SCTID:72011007",
          "UMLS:C0003507",
          "icd11.foundation:956813047"
        ],
        "synonyms": [
          "AS",
          "aortic stenosis",
          "rheumatic aortic stenosis",
          "rheumatic aortic valve stenosis",
          "stenosed aortic valve",
          "valvular aortic stenosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Aortic valve stenosis (AVS) is a condition characterized by narrowing of the heart's aortic valve opening. This narrowing prevents the valve from opening fully, which obstructs blood flow from the heart into the aorta, and onward to the rest of the body. AVS can range from mild to severe. Signs and symptoms typically develop when the narrowing of the opening is severe and may include chest pain (angina) or tightness; shortness of breath or fatigue (especially during exertion); feeling faint or fainting; heart palpitations; and heart murmur. Individuals with less severe congenital AVS (present at birth) may not develop symptoms until adulthood. Individuals with severe cases may faint without warning. AVS can have several causes including abnormal development before birth (such as having 1 or 2 valve leaflets instead of 3); calcium build-up on the valve in adulthood; and rheumatic fever."
      },
      "child_count": 8,
      "reference_id": "MONDO:0042981"
    }
  ],
  "roots": [
    {
      "id": 4883,
      "label": "heart valve disorder"
    },
    {
      "id": 7210,
      "label": "aortic disorder"
    },
    {
      "id": 23501,
      "label": "cardiac ventricle disorder"
    }
  ]
}