{
  "id": 5705,
  "label": "TSH producing pituitary tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003837",
  "properties": {
    "xrefs": [
      "DOID:6275",
      "GARD:0023689",
      "MEDGEN:391700",
      "NCIT:C7915",
      "SCTID:254959007",
      "UMLS:C2362538"
    ],
    "synonyms": [
      "TSH-producing pituitary gland tumor"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An adenoma or carcinoma of the anterior lobe of the pituitary gland that produces thyrotropin."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 5357,
      "label": "functioning pituitary gland adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5498,
        7896
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5395",
          "GARD:0021389",
          "MEDGEN:163135",
          "NCIT:C8388",
          "Orphanet:314753",
          "UMLS:C0854486"
        ],
        "synonyms": [
          "endocrine active pituitary adenoma",
          "functioning adenoma of pituitary",
          "functioning adenoma of pituitary gland",
          "functioning adenoma of the pituitary",
          "functioning adenoma of the pituitary gland",
          "functioning pituitary adenoma",
          "functioning pituitary gland adenoma",
          "functioning pituitary gland adenoma (benign)",
          "secreting pituitary adenoma",
          "secretory adenoma of pituitary",
          "secretory adenoma of pituitary gland",
          "secretory adenoma of the pituitary",
          "secretory adenoma of the pituitary gland",
          "secretory pituitary adenoma",
          "secretory pituitary gland adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A hormone producing pituitary gland adenoma, associated with a hormonal syndrome."
      },
      "child_count": 10,
      "reference_id": "MONDO:0003429"
    },
    {
      "id": 16048,
      "label": "thyroid tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4223,
        5187
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003841",
          "GARD:0019762",
          "ICD9:239.7",
          "MEDGEN:21546",
          "NCIT:C3414",
          "ONCOTREE:THYROID",
          "Orphanet:100087",
          "SCTID:127018007",
          "UMLS:C0040136"
        ],
        "synonyms": [
          "neoplasm of the thyroid",
          "neoplasm of the thyroid gland",
          "neoplasm of thyroid",
          "neoplasm of thyroid gland",
          "thyroid gland neoplasm",
          "thyroid gland neoplasm (disease)",
          "thyroid gland tumor",
          "thyroid gland tumour",
          "thyroid neoplasm",
          "thyroid neoplasms",
          "thyroid tumor",
          "tumor of the thyroid",
          "tumor of the thyroid gland",
          "tumor of thyroid",
          "tumor of thyroid gland",
          "tumour of the thyroid",
          "tumour of the thyroid gland",
          "tumour of thyroid",
          "tumour of thyroid gland",
          "THYROID"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm affecting the thyroid gland."
      },
      "child_count": 10,
      "reference_id": "MONDO:0015074"
    },
    {
      "id": 29359,
      "label": "secondary hyperthyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6233
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:923144",
          "UMLS:C1095928"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A form of hyperthyroidism caused by overproduction of thyroid hormones (T3 and T4) due to pathology outside of the thyroid gland, namely in the hypothalamus or pituitary gland. Secondary hyperthyroidism is characterized by elevated TSH levels and elevated T3/T4 levels."
      },
      "child_count": 2,
      "reference_id": "MONDO:1060201"
    }
  ],
  "children": [
    {
      "id": 5704,
      "label": "malignant thyroid stimulating hormone producing neoplasm of pituitary gland",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5705
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6274",
          "GARD:0023688",
          "MEDGEN:277341",
          "NCIT:C5965",
          "UMLS:C1334627"
        ],
        "synonyms": [
          "TSH producing pituitary gland carcinoma",
          "TSH-producing pituitary gland carcinoma",
          "malignant TSH producing neoplasm of pituitary",
          "malignant TSH producing neoplasm of pituitary gland",
          "malignant TSH producing neoplasm of the pituitary",
          "malignant TSH producing neoplasm of the pituitary gland",
          "malignant TSH producing pituitary gland neoplasm",
          "malignant TSH producing pituitary gland tumor",
          "malignant TSH producing pituitary gland tumour",
          "malignant TSH producing pituitary neoplasm",
          "malignant TSH producing pituitary tumor",
          "malignant TSH producing pituitary tumour",
          "malignant TSH producing tumor of pituitary",
          "malignant TSH producing tumor of pituitary gland",
          "malignant TSH producing tumor of the pituitary",
          "malignant TSH producing tumor of the pituitary gland",
          "malignant TSH producing tumour of pituitary",
          "malignant TSH producing tumour of pituitary gland",
          "malignant TSH producing tumour of the pituitary",
          "malignant TSH producing tumour of the pituitary gland",
          "malignant TSH secreting neoplasm of pituitary",
          "malignant TSH secreting neoplasm of pituitary gland",
          "malignant TSH secreting neoplasm of the pituitary",
          "malignant TSH secreting neoplasm of the pituitary gland",
          "malignant TSH secreting pituitary gland neoplasm",
          "malignant TSH secreting pituitary gland tumor",
          "malignant TSH secreting pituitary gland tumour",
          "malignant TSH secreting pituitary neoplasm",
          "malignant TSH secreting pituitary tumor",
          "malignant TSH secreting pituitary tumour",
          "malignant TSH secreting tumor of pituitary",
          "malignant TSH secreting tumor of pituitary gland",
          "malignant TSH secreting tumor of the pituitary",
          "malignant TSH secreting tumor of the pituitary gland",
          "malignant TSH secreting tumour of pituitary",
          "malignant TSH secreting tumour of pituitary gland",
          "malignant TSH secreting tumour of the pituitary",
          "malignant TSH secreting tumour of the pituitary gland",
          "malignant pituitary gland thyrotropinoma",
          "malignant pituitary thyrotropinoma",
          "malignant thyroid stimulating hormone producing neoplasm of pituitary",
          "malignant thyroid stimulating hormone producing neoplasm of pituitary gland",
          "malignant thyroid stimulating hormone producing neoplasm of the pituitary",
          "malignant thyroid stimulating hormone producing neoplasm of the pituitary gland",
          "malignant thyroid stimulating hormone producing pituitary gland neoplasm",
          "malignant thyroid stimulating hormone producing pituitary gland tumor",
          "malignant thyroid stimulating hormone producing pituitary gland tumour",
          "malignant thyroid stimulating hormone producing pituitary neoplasm",
          "malignant thyroid stimulating hormone producing pituitary tumor",
          "malignant thyroid stimulating hormone producing pituitary tumour",
          "malignant thyroid stimulating hormone producing tumor",
          "malignant thyroid stimulating hormone producing tumor of pituitary",
          "malignant thyroid stimulating hormone producing tumor of pituitary gland",
          "malignant thyroid stimulating hormone producing tumor of the pituitary",
          "malignant thyroid stimulating hormone producing tumor of the pituitary gland",
          "malignant thyroid stimulating hormone producing tumour",
          "malignant thyroid stimulating hormone producing tumour of pituitary",
          "malignant thyroid stimulating hormone producing tumour of pituitary gland",
          "malignant thyroid stimulating hormone producing tumour of the pituitary",
          "malignant thyroid stimulating hormone producing tumour of the pituitary gland",
          "malignant thyroid stimulating hormone secreting neoplasm of pituitary",
          "malignant thyroid stimulating hormone secreting neoplasm of pituitary gland",
          "malignant thyroid stimulating hormone secreting neoplasm of the pituitary",
          "malignant thyroid stimulating hormone secreting neoplasm of the pituitary gland",
          "malignant thyroid stimulating hormone secreting pituitary gland neoplasm",
          "malignant thyroid stimulating hormone secreting pituitary gland tumor",
          "malignant thyroid stimulating hormone secreting pituitary gland tumour",
          "malignant thyroid stimulating hormone secreting pituitary neoplasm",
          "malignant thyroid stimulating hormone secreting pituitary tumor",
          "malignant thyroid stimulating hormone secreting pituitary tumour",
          "malignant thyroid stimulating hormone secreting tumor of pituitary",
          "malignant thyroid stimulating hormone secreting tumor of pituitary gland",
          "malignant thyroid stimulating hormone secreting tumor of the pituitary",
          "malignant thyroid stimulating hormone secreting tumor of the pituitary gland",
          "malignant thyroid stimulating hormone secreting tumour of pituitary",
          "malignant thyroid stimulating hormone secreting tumour of pituitary gland",
          "malignant thyroid stimulating hormone secreting tumour of the pituitary",
          "malignant thyroid stimulating hormone secreting tumour of the pituitary gland",
          "malignant thyrotropinoma",
          "malignant thyrotropinoma of pituitary",
          "malignant thyrotropinoma of pituitary gland",
          "malignant thyrotropinoma of the pituitary",
          "malignant thyrotropinoma of the pituitary gland",
          "thyrotropin producing pituitary gland carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare, hormonally functioning or non-functioning pituitary gland adenocarcinoma that produces thyrotropin."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003836"
    },
    {
      "id": 19403,
      "label": "TSH-secreting pituitary adenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5705
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019157",
          "MEDGEN:87550",
          "NANDO:1200377",
          "NCIT:C8011",
          "Orphanet:91347",
          "UMLS:C0346303",
          "icd11.foundation:125504731"
        ],
        "synonyms": [
          "TSH producing adenoma of pituitary",
          "TSH producing adenoma of pituitary gland",
          "TSH producing adenoma of the pituitary",
          "TSH producing adenoma of the pituitary gland",
          "TSH producing pituitary adenoma",
          "TSH producing pituitary gland adenoma",
          "TSH secreting adenoma of pituitary",
          "TSH secreting adenoma of pituitary gland",
          "TSH secreting adenoma of the pituitary",
          "TSH secreting adenoma of the pituitary gland",
          "TSH secreting pituitary adenoma",
          "TSH secreting pituitary gland adenoma",
          "TSH-oma",
          "TSH-producing adenoma",
          "TSH-producing pituitary gland adenoma",
          "TSHoma",
          "pituitary thyrotrophic adenoma",
          "thyroid stimulating hormone producing adenoma of pituitary",
          "thyroid stimulating hormone producing adenoma of pituitary gland",
          "thyroid stimulating hormone producing adenoma of the pituitary",
          "thyroid stimulating hormone producing adenoma of the pituitary gland",
          "thyroid stimulating hormone producing pituitary adenoma",
          "thyroid stimulating hormone producing pituitary gland adenoma",
          "thyroid stimulating hormone secreting adenoma of pituitary",
          "thyroid stimulating hormone secreting adenoma of pituitary gland",
          "thyroid stimulating hormone secreting adenoma of the pituitary",
          "thyroid stimulating hormone secreting adenoma of the pituitary gland",
          "thyroid stimulating hormone secreting pituitary adenoma",
          "thyroid stimulating hormone secreting pituitary gland adenoma",
          "thyroid stimulating hormone-producing adenoma",
          "thyroid stimulating hormone-secreting pituitary adenoma",
          "thyrotrope adenoma",
          "thyrotroph adenoma",
          "thyrotrophic adenoma",
          "thyrotropin producing pituitary gland adenoma",
          "thyrotropinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare adenoma of the anterior lobe of the pituitary gland that produces thyrotropin. It is usually associated with goiter and hyperthyroidism."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019611"
    }
  ],
  "roots": [
    {
      "id": 5357,
      "label": "functioning pituitary gland adenoma"
    },
    {
      "id": 16048,
      "label": "thyroid tumor"
    },
    {
      "id": 29359,
      "label": "secondary hyperthyroidism"
    }
  ]
}