{
  "id": 5729,
  "label": "chronic lymphocytic leukemia/small lymphocytic lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003864",
  "properties": {
    "xrefs": [
      "DOID:6354",
      "GARD:0023704",
      "ICDO:9823/3",
      "MEDGEN:224906",
      "NCIT:C27911",
      "ONCOTREE:CLLSLL",
      "UMLS:C1302547"
    ],
    "synonyms": [
      "CLL/SLL",
      "chronic lymphocytic leukemia/small lymphocytic lymphoma",
      "chronic lymphocytic leukemia/small lymphocytic lymphoma (morphologic abnormality)"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "An indolent, mature B-cell neoplasm composed of small, round B-lymphocytes. When the bone marrow and peripheral blood are involved, the term chronic lymphocytic leukemia is used. The term small lymphocytic lymphoma is restricted to cases which do not show leukemic involvement of the bone marrow and peripheral blood."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6693,
      "label": "B-cell chronic lymphocytic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3274,
        6694,
        6710,
        17874
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1040",
          "EFO:0000095",
          "GARD:0006104",
          "ICD10CM:C91.1",
          "ICD9:204.1",
          "MEDGEN:44120",
          "MESH:D015451",
          "MedDRA:10008958",
          "NCIT:C3163",
          "NORD:971",
          "OMIM:151400",
          "Orphanet:67038",
          "UMLS:C0023434"
        ],
        "synonyms": [
          "B cell CLL",
          "B cell chronic lymphocytic leukaemia",
          "B cell chronic lymphocytic leukemia",
          "B cell lymphocytic leukaemia",
          "B cell lymphocytic leukemia",
          "B-CLL",
          "B-cell CLL",
          "B-cell chronic lymphocytic leukemia",
          "B-cell chronic lymphogenous leukaemia",
          "B-cell chronic lymphogenous leukemia",
          "B-cell chronic lymphoid leukaemia",
          "B-cell chronic lymphoid leukemia",
          "B-cell lymphocytic leukaemia",
          "B-cell lymphocytic leukemia",
          "BCLL",
          "CLL",
          "Chronic Lymphocytic Leukemia",
          "chronic B-cell lymphocytic leukaemia",
          "chronic B-cell lymphocytic leukemia",
          "chronic lymphatic leukemia",
          "chronic lymphocytic leukaemia (CLL)",
          "chronic lymphocytic leukemia",
          "chronic lymphocytic leukemia (CLL)",
          "chronic lymphogenous leukaemia",
          "chronic lymphogenous leukemia",
          "hematopoeitic - chronic lymphocytic leukaemia (CLL)",
          "hematopoeitic - chronic lymphocytic leukemia (CLL)",
          "lymphoplasmacytic leukemia",
          "leukemia, chronic LYMPHOCYTIC",
          "leukemia, chronic lymphatic",
          "leukemia, lymphocytic, chronic",
          "small lymphocytic lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "B-cell chronic lymphocytic leukemia (B-CLL) is a type of B-cell non-Hodgkin lymphoma, and the most common form of leukemia in Western countries, affecting elderly adults (mean age of 67 and 72 years) with a slight male predominance (1.7:1), and characterized by a highly variable clinical presentation that can include asymptomatic disease or non-specific B-symptoms such as unintentional weight loss, severe fatigue, fever (without evidence of infection), and night sweats as well as cervical lymphadenopathy, splenomegaly and frequent infections. Some patients can also develop autoimmune complications such as autoimmune hemolytic anemia or immune thrombocytopenia. The clinical course is extremely heterogeneous with survival ranging from a few months to several decades."
      },
      "child_count": 8,
      "reference_id": "MONDO:0004948"
    }
  ],
  "children": [
    {
      "id": 5979,
      "label": "chronic lymphocytic leukemia/small lymphocytic lymphoma with immunoglobulin heavy chain variable-region gene somatic hypermutation",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5729
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7230",
          "GARD:0023852",
          "MEDGEN:232076",
          "NCIT:C37201",
          "UMLS:C1333037"
        ],
        "synonyms": [
          "CLL/SLL with IGVH SHM",
          "chronic lymphocytic leukemia/small lymphocytic lymphoma with immunoglobulin heavy chain variable-region gene somatic hypermutation",
          "postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma",
          "postgerminal centre chronic lymphocytic leukemia/small lymphocytic lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A recently recognized variant of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) expressing somatic hypermutations of the Immunoglobulin heavy chain (IGH) genes. The recognition of this variant alters the belief that CLL/SLL is always derived from a naive, pregerminal center B-cell. The presence of somatic hypermutations of IGH genes occurs in approximately 50% of CLL/SLL cases and implies a postgerminal center, memory origin. Patients with this variant of CLL/SLL have a favorable prognosis, with a reported median survival of more than 24 years."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004152"
    },
    {
      "id": 6282,
      "label": "pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5729
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8144",
          "GARD:0024026",
          "MEDGEN:234146",
          "NCIT:C37204",
          "UMLS:C1333038"
        ],
        "synonyms": [
          "CLL/SLL with unmutated IGVH",
          "chronic lymphocytic leukemia/small lymphocytic lymphoma with unmutated Immunoglobulin heavy chain variable-region Gene",
          "pregerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A recently recognized variant of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) that lacks somatic hypermutations of the Immunoglobulin heavy chain (IGH) genes, implying pregerminal center B-cell origin. Microarray gene expression profiling studies have demonstrated the expression of ZAP-70 gene (Syk family tyrosine kinase) in this subset of CLL/CLL. Patients with this variant of CLL/SLL have an unfavorable prognosis compared to those with somatic hypermutations of the IGH genes, with a median survival of approximately 6-8 years."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004478"
    }
  ],
  "roots": [
    {
      "id": 6693,
      "label": "B-cell chronic lymphocytic leukemia"
    }
  ]
}