{
  "id": 5741,
  "label": "malignant choroid melanoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003878",
  "properties": {
    "xrefs": [
      "DOID:6438",
      "GARD:0023710",
      "MEDGEN:138064",
      "NCIT:C4561",
      "SCTID:255021005",
      "UMLS:C0346388"
    ],
    "synonyms": [
      "choroid malignant melanoma",
      "choroid melanoma",
      "choroidal melanoma",
      "malignant melanoma of choroid",
      "malignant melanoma of the choroid",
      "melanoma (disease) of optic choroid",
      "melanoma of choroid",
      "melanoma of the choroid",
      "optic choroid melanoma",
      "optic choroid melanoma (disease)"
    ],
    "categories": [
      {
        "ref": "MONDO:0002022",
        "name": "disorder of orbital region"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      }
    ],
    "definition": "A uveal melanoma that arises from the choroid. It is the most common primary malignant intraocular tumor. It usually affects Caucasians of northern European descent. It usually remains asymptomatic for a long period. When signs and symptoms occur, they include blurred vision, visual field loss, floaters, and ocular pain. Tumor size is the most important factor that relates to prognosis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 7983,
      "label": "uveal melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4710,
        7858
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6039",
          "EFO:1000616",
          "GARD:0008621",
          "MEDGEN:65077",
          "MESH:C536494",
          "MedDRA:10061252",
          "NCIT:C7712",
          "OMIM:155720",
          "ONCOTREE:UM",
          "Orphanet:39044",
          "UMLS:C0220633"
        ],
        "synonyms": [
          "intraocular melanoma",
          "melanoma (disease) of uvea",
          "melanoma of the uvea",
          "melanoma of uvea",
          "melanoma, uveal, malignant",
          "uvea melanoma",
          "uvea melanoma (disease)",
          "uveal melanoma",
          "iris melanoma",
          "choroidal melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A melanoma derived from melanocytes of the uveal tract. It is the most common primary intraocular tumor in the United States and Western Europe. Similar to melanoma of the skin, it is rare in Africa and Asia. Diagnostic procedures include ophthalmoscopic exam, fluorescein angiography and ultrasound. Treatment includes: surgical excision of the eye, iridocyclectomy and tumor resection. Recent treatments also include radiotherapy or photo coagulation. Classification of uveal melanomas recognizes four cell types within these tumors: epithelioid, intermediate, mixed cell, and spindle cell types. The spindle cell type uveal melanomas are further sub-classified as spindle cell type A and spindle cell type B."
      },
      "child_count": 16,
      "reference_id": "MONDO:0006486"
    },
    {
      "id": 8163,
      "label": "choroid cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4233,
        4710,
        20462,
        23165
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12759",
          "ICD10CM:C69.3",
          "ICD9:190.6",
          "MEDGEN:57794",
          "MESH:D002830",
          "MedDRA:10057405",
          "NCIT:C3566",
          "SCTID:363466008",
          "UMLS:C0153630"
        ],
        "synonyms": [
          "choroid neoplasm",
          "choroidal tumor",
          "choroidal tumour",
          "cancer of optic choroid",
          "malignant choroid neoplasm",
          "malignant choroid tumor",
          "malignant choroid tumour",
          "malignant neoplasm of choroid",
          "malignant neoplasm of optic choroid",
          "malignant neoplasm of the choroid",
          "malignant optic choroid neoplasm",
          "malignant tumor of choroid",
          "malignant tumor of the choroid",
          "malignant tumour of choroid",
          "malignant tumour of the choroid",
          "optic choroid cancer"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A malignant neoplasm involving the optic choroid."
      },
      "child_count": 4,
      "reference_id": "MONDO:0006700"
    }
  ],
  "children": [
    {
      "id": 5625,
      "label": "choroid spindle cell melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5624,
        5741
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6041",
          "GARD:0023647",
          "MEDGEN:272477",
          "NCIT:C6099",
          "UMLS:C1333027"
        ],
        "synonyms": [
          "optic choroid spindle cell melanoma",
          "spindle cell melanoma of choroid",
          "spindle cell melanoma of optic choroid",
          "spindle cell melanoma of the choroid"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A spindle cell melanoma that involves the optic choroid."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003745"
    },
    {
      "id": 5775,
      "label": "choroid mixed cell melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5741,
        5772
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6525",
          "GARD:0023731",
          "MEDGEN:232361",
          "NCIT:C35782",
          "UMLS:C1333025"
        ],
        "synonyms": [
          "choroid mixed cell melanoma",
          "mixed cell uveal melanoma of optic choroid",
          "optic choroid mixed cell uveal melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A mixed cell uveal melanoma that involves the optic choroid."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003913"
    },
    {
      "id": 5905,
      "label": "intermediate cell type choroid melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5741,
        5902
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6996",
          "GARD:0023803",
          "MEDGEN:272760",
          "NCIT:C6100",
          "UMLS:C1334208"
        ],
        "synonyms": [
          "Intermediate cell type choroid melanoma",
          "intermediate cell type uveal melanoma of optic choroid",
          "optic choroid intermediate cell type uveal melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Choroid melanoma characterized by the presence of intermediate cells which are similar to but smaller than epithelioid cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004065"
    },
    {
      "id": 5920,
      "label": "choroid epithelioid cell melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5741,
        7755
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7041",
          "GARD:0023810",
          "MEDGEN:232360",
          "NCIT:C6102",
          "UMLS:C1333024"
        ],
        "synonyms": [
          "choroid epithelioid cell melanoma",
          "choroidal epithelioid cell melanoma",
          "epithelioid cell melanoma of choroid",
          "epithelioid cell melanoma of optic choroid",
          "epithelioid cell melanoma of the choroid",
          "optic choroid epithelioid cell melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A epithelioid cell melanoma that involves the optic choroid."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004085"
    },
    {
      "id": 6177,
      "label": "choroid necrotic melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5741,
        6178
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7807",
          "GARD:0023958",
          "MEDGEN:232362",
          "NCIT:C6865",
          "UMLS:C1333026"
        ],
        "synonyms": [
          "choroid necrotic melanoma",
          "necrotic choroid melanoma",
          "necrotic melanoma of choroid",
          "necrotic melanoma of the choroid"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0004364"
    }
  ],
  "roots": [
    {
      "id": 7983,
      "label": "uveal melanoma"
    },
    {
      "id": 8163,
      "label": "choroid cancer"
    }
  ]
}