{
  "id": 5783,
  "label": "adrenal cortex adenoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003924",
  "properties": {
    "xrefs": [
      "DOID:0050891",
      "DOID:656",
      "EFO:0003104",
      "GARD:0027656",
      "HP:0008196",
      "HP:0008256",
      "ICDO:8370/0",
      "MEDGEN:61654",
      "MESH:D018246",
      "NANDO:2200352",
      "NCIT:C9003",
      "ONCOTREE:ACA",
      "Orphanet:99888",
      "SCTID:302826002",
      "UMLS:C0206667"
    ],
    "synonyms": [
      "adenoma of adrenal cortex",
      "adenoma of adrenal gland",
      "adenoma of the adrenal cortex",
      "adenoma of the adrenal gland",
      "adenoma, adrenocortical, benign",
      "adrenal adenoma",
      "adrenal cortex adenoma",
      "adrenal cortical adenoma",
      "adrenal gland adenoma",
      "adrenocortical adenoma",
      "benign adenoma of adrenal gland",
      "benign adenoma of the adrenal gland",
      "benign adrenal adenoma",
      "benign adrenal gland adenoma",
      "cortical cell adenoma",
      "adrenal incidentaloma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A benign neoplasm that can arise from any of the adrenal cortical layers. It can be associated with the overproduction of glucocorticoids (Cushing's syndrome), androgenic or estrogenic steroids (adrenogenital syndrome), or mineralocorticoids (Conn's syndrome). (Sternberg Diagnostic Surgical Pathology, 3rd ed.)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 6714,
      "label": "adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:657",
          "EFO:0000232",
          "ICDO:8140/0",
          "MEDGEN:125",
          "MESH:D000236",
          "NCIT:C2855",
          "SCTID:443416007",
          "UMLS:C0001430"
        ],
        "synonyms": [
          "adenoma",
          "acinar cell adenoma",
          "acinar cell adenoma (morphologic abnormality)",
          "adenoma, benign"
        ],
        "definition": "A neoplasm arising from the epithelium. It may be encapsulated or non-encapsulated but non-invasive. The neoplastic epithelial cells may or may not display cellular atypia or dysplasia. In the gastrointestinal tract, when dysplasia becomes severe it is sometimes called carcinoma in situ. Representative examples are pituitary gland adenoma, follicular adenoma of the thyroid gland, and adenomas (or adenomatous polyps) of the gastrointestinal tract."
      },
      "child_count": 31,
      "reference_id": "MONDO:0004972"
    },
    {
      "id": 20630,
      "label": "benign neoplasm of adrenal gland",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3032,
        20437
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025326",
          "ICD10CM:D35.0",
          "ICD9:227.0",
          "MEDGEN:56330",
          "NCIT:C3629",
          "SCTID:91967007",
          "UMLS:C0154040",
          "icd11.foundation:2121003176"
        ],
        "synonyms": [
          "adrenal gland benign neoplasm",
          "benign adrenal gland neoplasm",
          "benign adrenal gland tumor",
          "benign adrenal gland tumour",
          "benign adrenal neoplasm",
          "benign adrenal tumor",
          "benign adrenal tumour",
          "benign neoplasm of the adrenal gland",
          "benign tumor of adrenal gland",
          "benign tumor of the adrenal gland",
          "benign tumour of adrenal gland",
          "benign tumour of the adrenal gland"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign neoplasm that involves the adrenal gland."
      },
      "child_count": 6,
      "reference_id": "MONDO:0021511"
    },
    {
      "id": 22943,
      "label": "adrenal cortex neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4842,
        20437
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025820",
          "MEDGEN:1350",
          "MESH:D000306",
          "NCIT:C2858",
          "UMLS:C0001618"
        ],
        "synonyms": [
          "adrenal cortex neoplasm",
          "adrenal cortex tumor",
          "adrenal cortex tumour",
          "adrenocortical neoplasm",
          "adrenocortical tumor",
          "adrenocortical tumour",
          "neoplasm of adrenal cortex",
          "tumor of adrenal cortex",
          "tumour of adrenal cortex"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant (primary or metastatic) neoplasm affecting the adrenal cortex. (NCI05)"
      },
      "child_count": 6,
      "reference_id": "MONDO:0036591"
    },
    {
      "id": 22952,
      "label": "benign epithelial neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6887,
        7265
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICDO:8010/0",
          "ICDO:8011/0",
          "MEDGEN:90747",
          "NCIT:C4092",
          "UMLS:C0334232"
        ],
        "synonyms": [
          "benign epithelial neoplasm",
          "benign epithelial tumor",
          "benign epithelial tumour",
          "benign epithelioma",
          "benign neoplasm of epithelium",
          "benign neoplasm of the epithelium",
          "benign tumor of epithelium",
          "benign tumor of the epithelium",
          "benign tumour of epithelium",
          "benign tumour of the epithelium",
          "epithelial neoplasm, benign",
          "epithelioma, benign"
        ],
        "definition": "A neoplasm arising from the epithelial cells. It is characterized by the absence of morphologic features associated with malignancy (severe cytologic atypia, tumor cell necrosis, and high mitotic rate). Benign epithelial neoplasms remain confined to the original site of growth and only rarely metastasize to other anatomic sites."
      },
      "child_count": 50,
      "reference_id": "MONDO:0036976"
    }
  ],
  "children": [
    {
      "id": 7733,
      "label": "cortisol-producing adrenal cortex adenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5783
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000208",
          "GARD:0024319",
          "MEDGEN:353568",
          "NCIT:C48449",
          "UMLS:C1707525"
        ],
        "synonyms": [
          "cortisol producing adrenal cortex adenoma",
          "cortisol producing adrenal cortical adenoma",
          "cortisol-producing adrenal cortex adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenoma of the adrenal cortex that produces cortisol. It may be associated with Cushing syndrome. Clinical presentation includes weight gain, round face, easy bruising, muscle weakness, emotional changes, hirsutism, and hypertension."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006174"
    },
    {
      "id": 7854,
      "label": "non-functioning adrenal cortex adenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5783,
        20358
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000399",
          "GARD:0024370",
          "MEDGEN:313501",
          "NCIT:C48458",
          "UMLS:C1709240"
        ],
        "synonyms": [
          "adrenal cortex non-functioning endocrine neoplasm",
          "adrenal cortical incidentaloma",
          "non-functioning adrenal cortex adenoma",
          "non-functioning adrenal cortical adenoma",
          "non-functioning endocrine neoplasm of adrenal cortex",
          "nonfunctional adrenal cortex adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenoma of the adrenal cortex characterized by the absence of a hormonal syndrome or symptoms suggestive of adrenal disease."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006321"
    },
    {
      "id": 7927,
      "label": "sex hormone-producing adrenal cortex adenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5783
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000523",
          "GARD:0024402",
          "MEDGEN:328025",
          "NCIT:C48452",
          "UMLS:C1710067"
        ],
        "synonyms": [
          "Sex hormone producing adrenal cortex adenoma",
          "Sex hormone producing adrenal cortical adenoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare adenoma of the adrenal cortex that produces androgens or estrogens."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006408"
    },
    {
      "id": 17010,
      "label": "aldosterone-producing adrenal cortex adenoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3643,
        5783
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000015",
          "GARD:0020621",
          "MEDGEN:353374",
          "MedDRA:10056950",
          "NCIT:C48451",
          "Orphanet:231625",
          "UMLS:C1706762"
        ],
        "synonyms": [
          "APAC",
          "Pure APAC",
          "Pure aldosterone-producing adrenocortical carcinoma",
          "Pure aldosterone-secreting adrenocortical carcinoma",
          "aldosterone producing adrenal cortex adenoma",
          "aldosterone producing adrenal cortical adenoma",
          "aldosterone-producing adrenal cortex adenoma",
          "adrenocortical carcinoma with pure aldosterone hypersecretion"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenoma of the adrenal cortex that produces aldosterone. It may be associated with Conn syndrome. Clinical presentation includes hypertension, hypokalemia, and muscle weakness."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016505"
    }
  ],
  "roots": [
    {
      "id": 6714,
      "label": "adenoma"
    },
    {
      "id": 20630,
      "label": "benign neoplasm of adrenal gland"
    },
    {
      "id": 22943,
      "label": "adrenal cortex neoplasm"
    },
    {
      "id": 22952,
      "label": "benign epithelial neoplasm"
    }
  ]
}