{
  "id": 5789,
  "label": "non-invasive bladder urothelial carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003930",
  "properties": {
    "xrefs": [
      "DOID:6571",
      "GARD:0023742",
      "MEDGEN:233466",
      "NCIT:C6188",
      "UMLS:C1336089"
    ],
    "synonyms": [
      "non-invasive bladder urothelial carcinoma",
      "stage 0 bladder urothelial cancer",
      "stage 0 bladder urothelial carcinoma",
      "stage 0 bladder urothelial carcinoma aJCC v6",
      "stage 0 bladder urothelial carcinoma aJCC v6 and v7",
      "stage 0 bladder urothelial carcinoma aJCC v7",
      "stage 0 transitional cell carcinoma of bladder",
      "stage 0 transitional cell carcinoma of the bladder",
      "stage 0 transitional cell carcinoma of the urinary bladder",
      "stage 0 transitional cell carcinoma of urinary bladder",
      "stage 0 urinary bladder transitional cell carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002118",
        "name": "urinary system disorder"
      }
    ],
    "definition": "Stage 0 includes: 0a (Ta, N0, M0); 0is (Tis, N0, M0). Ta: Noninvasive papillary carcinoma. Tis: Carcinoma in situ: \"flat tumor\". N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 7252,
      "label": "bladder transitional cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6727,
        23006
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4006",
          "EFO:0006544",
          "MEDGEN:76013",
          "NCIT:C39851",
          "ONCOTREE:BLCA",
          "SCTID:255109008",
          "UMLS:C0279680"
        ],
        "synonyms": [
          "bladder transitional cell carcinoma",
          "bladder urothelial cancer",
          "bladder urothelial carcinoma",
          "transitional cell carcinoma of the urinary bladder",
          "urinary bladder transitional cell carcinoma",
          "urinary bladder urothelial carcinoma",
          "urothelial carcinoma of the urinary bladder",
          "BLCA"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "The most common morphologic subtype of urinary bladder carcinoma (over 90% of cases). It arises from the transitional epithelium. It most often affects males in their sixth and seventh decades of life. Hematuria is the most common symptom at presentation. Pathologic stage is the strongest predictor of survival."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005611"
    }
  ],
  "children": [
    {
      "id": 6483,
      "label": "bladder carcinoma in situ",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5789,
        6433,
        7681
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9053",
          "GARD:0024091",
          "ICD10CM:D09.0",
          "ICD9:233.7",
          "MEDGEN:57584",
          "NCIT:C3644",
          "SCTID:92546004",
          "UMLS:C0154091"
        ],
        "synonyms": [
          "cancer in situ of urinary bladder",
          "bladder flat CIS",
          "bladder flat carcinoma in situ",
          "carcinoma in situ of bladder",
          "carcinoma in situ of the urinary bladder",
          "carcinoma in situ of urinary bladder",
          "flat CIS of the bladder",
          "flat CIS of the urinary bladder",
          "flat carcinoma in situ of the bladder",
          "flat carcinoma in situ of the urinary bladder",
          "high grade bladder Intraurothelial neoplasia",
          "stage 0 urinary bladder carcinoma",
          "stage 0is bladder cancer",
          "stage 0is bladder carcinoma",
          "stage 0is bladder urothelial cancer",
          "stage 0is bladder urothelial carcinoma",
          "stage 0is bladder urothelial carcinoma aJCC v6",
          "stage 0is bladder urothelial carcinoma aJCC v6 and v7",
          "stage 0is bladder urothelial carcinoma aJCC v7",
          "stage 0is carcinoma of bladder",
          "stage 0is carcinoma of the bladder",
          "stage 0is carcinoma of the urinary bladder",
          "stage 0is carcinoma of urinary bladder",
          "stage 0is urinary bladder carcinoma",
          "urinary bladder carcinoma in situ",
          "urinary bladder flat CIS",
          "urinary bladder flat carcinoma in situ",
          "urinary bladder in situ carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          }
        ],
        "definition": "Also known as carcinoma in situ of the urinary bladder or high grade intraurothelial neoplasia, this is a flat lesion of the transitional cell epithelium characterized by severe cytologic atypia. This lesion is confined to the urothelium, and is a precursor of invasive transitional cell carcinoma of the bladder. Stage 0is includes: Tis, N0, M0. Tis: Carcinoma in situ: \"flat tumor\". N0: No regional lymph node metastasis. M0: No distant metastasis. (AJCC 6th and 7th eds.)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004703"
    }
  ],
  "roots": [
    {
      "id": 7252,
      "label": "bladder transitional cell carcinoma"
    }
  ]
}