{
  "id": 5808,
  "label": "nipple carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003950",
  "properties": {
    "xrefs": [
      "DOID:6629",
      "MEDGEN:233756",
      "NCIT:C28432",
      "UMLS:C1334966"
    ],
    "synonyms": [
      "carcinoma of nipple",
      "nipple cancer",
      "nipple carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0002657",
        "name": "breast disorder"
      }
    ],
    "definition": "A carcinoma that arises from epithelial cells of the nipple"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 3053,
      "label": "integumentary system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4198,
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060122"
        ],
        "synonyms": [
          "cancer of integumental system",
          "integumental system cancer",
          "malignant integumental system neoplasm",
          "malignant neoplasm of integumental system"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the integumental system"
      },
      "child_count": 14,
      "reference_id": "MONDO:0000653"
    },
    {
      "id": 4562,
      "label": "nipple neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4198,
        20340
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3003",
          "MEDGEN:205111",
          "NCIT:C5212",
          "UMLS:C1112166"
        ],
        "synonyms": [
          "neoplasm of nipple",
          "neoplasm of the nipple",
          "nipple neoplasm",
          "nipple neoplasm (disease)",
          "nipple tumor",
          "nipple tumour",
          "tumor of nipple",
          "tumor of the nipple",
          "tumour of nipple",
          "tumour of the nipple"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that arises in the area of the nipple."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002482"
    },
    {
      "id": 6730,
      "label": "breast carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6734,
        8659
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3459",
          "EFO:0000305",
          "HP:0003002",
          "MEDGEN:146260",
          "NCIT:C4872",
          "SCTID:254838004",
          "UMLS:C0678222"
        ],
        "synonyms": [
          "breast cancer",
          "breast cancer, NOS",
          "cancer of breast",
          "cancer of the breast",
          "cancer, breast",
          "breast carcinoma",
          "carcinoma of breast",
          "carcinoma of the breast",
          "mammary carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the breast"
      },
      "child_count": 26,
      "reference_id": "MONDO:0004989"
    }
  ],
  "children": [
    {
      "id": 6218,
      "label": "nipple duct carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5808
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7953",
          "MEDGEN:233757",
          "NCIT:C27234",
          "UMLS:C1334967"
        ],
        "synonyms": [
          "nipple duct carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma that develops in the ducts of the nipple."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004409"
    },
    {
      "id": 16599,
      "label": "Paget disease of the nipple",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4699,
        5808
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0007303",
          "MEDGEN:352830",
          "MedDRA:10033367",
          "NCIT:C3301",
          "NORD:1544",
          "ONCOTREE:PD",
          "Orphanet:180275",
          "SCTID:403946000",
          "UMLS:C1704323",
          "icd11.foundation:1295910447"
        ],
        "synonyms": [
          "Paget disease of the breast",
          "mammary Paget disease",
          "Paget disease of the nipple",
          "Paget's Disease of the Breast",
          "Paget's disease of nipple",
          "Paget's disease of the nipple",
          "nipple Paget's disease",
          "PD",
          "Paget's disease, mammary"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "Paget disease of the nipple describes a rare presentation of breast cancer, seen most frequently in women aged 50-60, manifesting with nipple drainage and itching, erythema, crusty and excoriated nipple, thickened plaques, and hyperpigmentation (less frequently). It is due to tumor cells invading the nipple-areola complex and represents 1-3% of all new breast cancer diagnoses."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015873"
    }
  ],
  "roots": [
    {
      "id": 3053,
      "label": "integumentary system cancer"
    },
    {
      "id": 4562,
      "label": "nipple neoplasm"
    },
    {
      "id": 6730,
      "label": "breast carcinoma"
    }
  ]
}