{
  "id": 5818,
  "label": "pulmonary large cell neuroendocrine carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003960",
  "properties": {
    "xrefs": [
      "DOID:6658",
      "GARD:0023754",
      "MEDGEN:233608",
      "NCIT:C5672",
      "UMLS:C1334363"
    ],
    "synonyms": [
      "LCNEC of the lung",
      "large cell lung carcinoma with neuroendocrine differentiation",
      "large cell lung neuroendocrine carcinoma",
      "large cell neuroendocrine carcinoma of lung",
      "large cell neuroendocrine carcinoma of the lung",
      "lung large cell neuroendocrine carcinoma",
      "pulmonary large cell neuroendocrine carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A large cell neuroendocrine carcinoma that involves the lung(s)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 5040,
      "label": "lung large cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6943,
        6944
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4556",
          "EFO:0003050",
          "ICD9:162.9",
          "MEDGEN:91060",
          "NCIT:C4450",
          "ONCOTREE:LCLC",
          "SCTID:254629004",
          "UMLS:C0345958"
        ],
        "synonyms": [
          "anaplastic lung carcinoma",
          "large cell carcinoma of lung",
          "large cell carcinoma of the lung",
          "large cell lung cancer",
          "large cell lung carcinoma",
          "large cell undifferentiated lung carcinoma",
          "lung large cell carcinoma",
          "LCLC"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A poorly differentiated non-small cell lung carcinoma composed of large polygonal cells without evidence of glandular or squamous differentiation. There is a male predilection."
      },
      "child_count": 14,
      "reference_id": "MONDO:0003050"
    },
    {
      "id": 6787,
      "label": "large cell neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255,
        6943
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050872",
          "EFO:0000563",
          "GARD:0024145",
          "ICDO:8013/3",
          "MEDGEN:220402",
          "NCIT:C6875",
          "ONCOTREE:LUNE",
          "UMLS:C1265996",
          "icd11.foundation:1278312485"
        ],
        "synonyms": [
          "LCNEC",
          "large cell NEC",
          "large cell neuroendocrine carcinoma",
          "large-cell neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A usually aggressive carcinoma composed of large malignant cells which display neuroendocrine characteristics. It is characterized by the presence of high mitotic activity and necrotic changes. The vast majority of cases are positive for neuron-specific enolase. Representative examples include lung, breast, cervical, and thymic neuroendocrine carcinomas."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005057"
    },
    {
      "id": 7117,
      "label": "lung neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19314,
        20356
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5410",
          "EFO:0005220",
          "GARD:0024190",
          "ICD9:209.61",
          "MEDGEN:277303",
          "NCIT:C5670",
          "ONCOTREE:LNET",
          "SCTID:707594002",
          "UMLS:C1334452"
        ],
        "synonyms": [
          "lung NET",
          "lung neuroendocrine neoplasm",
          "lung neuroendocrine tumor",
          "lung neuroendocrine tumor, well differentiated, low or intermediate grade",
          "lung neuroendocrine tumour",
          "neuroendocrine neoplasm of lung",
          "neuroendocrine neoplasm of the lung",
          "pulmonary neuroendocrine neoplasm",
          "pulmonary neuroendocrine tumor",
          "pulmonary neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A low, intermediate, or high grade malignant neoplasm with neuroendocrine differentiation that arises from the lung. This category includes typical carcinoid tumor, atypical carcinoid tumor, small cell carcinoma, large cell neuroendocrine carcinoma, and combined carcinoma."
      },
      "child_count": 10,
      "reference_id": "MONDO:0005454"
    }
  ],
  "children": [
    {
      "id": 5969,
      "label": "lung combined large cell neuroendocrine carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5818,
        7728
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7207",
          "GARD:0023843",
          "MEDGEN:232386",
          "NCIT:C7267",
          "UMLS:C1333122"
        ],
        "synonyms": [
          "combined large cell lung neuroendocrine carcinoma",
          "combined large cell neuroendocrine carcinoma of lung",
          "combined large cell neuroendocrine carcinoma of the lung",
          "pulmonary combined large cell neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A subtype of large cell neuroendocrine lung carcinoma characterized by the presence of large neuroendocrine cells in combination with adenocarcinoma, squamous cell carcinoma, giant cell carcinoma and/ or spindle cell carcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004142"
    }
  ],
  "roots": [
    {
      "id": 5040,
      "label": "lung large cell carcinoma"
    },
    {
      "id": 6787,
      "label": "large cell neuroendocrine carcinoma"
    },
    {
      "id": 7117,
      "label": "lung neuroendocrine neoplasm"
    }
  ]
}