{
  "id": 5849,
  "label": "basal ganglia disorder",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0003996",
  "properties": {
    "xrefs": [
      "CSP:2057-3403",
      "DOID:679",
      "EFO:0009533",
      "ICD9:333.0",
      "MEDGEN:1619147",
      "MESH:D001480",
      "SCTID:70835005",
      "UMLS:C4520981"
    ],
    "synonyms": [
      "basal ganglia disease",
      "collection of basal ganglia disease",
      "collection of basal ganglia disease or disorder",
      "disease of basal ganglia",
      "disease of collection of basal ganglia",
      "disease or disorder of collection of basal ganglia",
      "disorder of collection of basal ganglia",
      "disorder of basal ganglia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A disease involving the basal ganglia."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 7209,
      "label": "brain disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:936",
          "EFO:0005774",
          "ICD9:348.3",
          "ICD9:348.30",
          "ICD9:348.8",
          "ICD9:348.9",
          "MEDGEN:14214",
          "MESH:D001927",
          "NCIT:C96413",
          "SCTID:81308009",
          "UMLS:C0006111"
        ],
        "synonyms": [
          "brain disease",
          "brain disease or disorder",
          "disease of brain",
          "disease or disorder of brain",
          "disorder of brain",
          "encephalopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease affecting the brain or part of the brain."
      },
      "child_count": 71,
      "reference_id": "MONDO:0005560"
    }
  ],
  "children": [
    {
      "id": 7997,
      "label": "basal ganglia cerebrovascular disorder",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5849,
        12183
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10991",
          "EFO:1000640",
          "MEDGEN:148381",
          "MESH:D020144",
          "UMLS:C0751739"
        ],
        "synonyms": [
          "cerebrovascular disorder of collection of basal ganglia",
          "collection of basal ganglia cerebrovascular disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A pathological condition caused by impaired blood flow in the basal regions of cerebral hemispheres (basal ganglia), such as infarction; hemorrhage; or ischemia in vessels of this brain region including the lateral lenticulostriate arteries. Primary clinical manifestations include involuntary movements (dyskinesias) and muscle weakness (hemiparesis)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006505"
    },
    {
      "id": 10207,
      "label": "bilateral striopallidodentate calcinosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5849,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060230",
          "GARD:0006406",
          "HP:0002135",
          "ICD9:333.0",
          "ICD9:348.89",
          "MESH:C536275",
          "MedDRA:10059626",
          "NANDO:1200207",
          "NORD:1127",
          "OMIMPS:213600",
          "Orphanet:1980",
          "SCTID:110997000",
          "SCTID:230311004",
          "icd11.foundation:1081370436"
        ],
        "synonyms": [
          "BSPDC",
          "PFBC",
          "Primary Familial Brain Calcification",
          "basal ganglia calcification",
          "basal ganglia degeneration with calcification",
          "cerebrovascular ferrocalcinosis",
          "primary familial brain calcification",
          "Fahr disease",
          "idiopathic basal ganglia calcification",
          "basal ganglia calcification, idiopathic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A basal ganglia disease characterized by the accumulation of calcium deposits in different brain regions, particularly the basal ganglia and dentate nucleus, and is often associated with neurodegeneration."
      },
      "child_count": 20,
      "reference_id": "MONDO:0008947"
    },
    {
      "id": 12922,
      "label": "biotin-responsive basal ganglia disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        2745,
        5849,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050659",
          "GARD:0010237",
          "ICD9:333.99",
          "MEDGEN:375289",
          "MESH:C537658",
          "OMIM:607483",
          "Orphanet:199348",
          "Orphanet:65284",
          "SCTID:703522009",
          "SCTID:723557004",
          "UMLS:C1843807",
          "icd11.foundation:1776831202"
        ],
        "synonyms": [
          "BBGD",
          "BTBGD",
          "THMD2",
          "biotin-responsive basal ganglia disease",
          "biotin-thiamine-responsive basal ganglia disease",
          "encephalopathy, thiamine-responsive",
          "thiamine metabolism dysfunction syndrome 2 (biotin- and thiamine-responsive type)",
          "thiamine-responsive encephalopathy",
          "thiamine metabolism dysfunction syndrome 2 (biotin- or thiamine-responsive type)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Any thiamine-responsive dysfunction syndrome in which the cause of the disease is a variation in the SLC19A3 gene, characterized by subacute encephalopathy with confusion, seizures, and movement disorder, often following a history of febrile illness."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011841"
    },
    {
      "id": 20335,
      "label": "parkinsonian disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5849
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080855",
          "MEDGEN:66079",
          "MESH:D020734",
          "UMLS:C0242422"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA."
      },
      "child_count": 21,
      "reference_id": "MONDO:0021095"
    }
  ],
  "roots": [
    {
      "id": 7209,
      "label": "brain disorder"
    }
  ]
}