{
  "id": 5857,
  "label": "breast intraductal proliferative lesion",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004007",
  "properties": {
    "xrefs": [
      "DOID:6839",
      "MEDGEN:277343",
      "NCIT:C27942",
      "UMLS:C1334631"
    ],
    "synonyms": [
      "DIN",
      "ductal intraepithelial neoplasia",
      "intraductal proliferative lesion",
      "intraductal proliferative lesion of the breast",
      "mammary intraepithelial neoplasia, ductal type"
    ],
    "categories": [
      {
        "ref": "MONDO:0002657",
        "name": "breast disorder"
      }
    ],
    "definition": "A group of non-invasive epithelial proliferations that occur in the ductal system of the breast. The vast majority of cases arise in the terminal ductal lobular units. This category includes atypical ductal hyperplasia, usual ductal hyperplasia, flat epithelial atypia, and ductal carcinoma in situ. There is an increased risk for subsequent development of invasive breast carcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4567,
      "label": "intraductal breast neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20340
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3013",
          "MEDGEN:184927",
          "NCIT:C36083",
          "UMLS:C0948967"
        ],
        "synonyms": [
          "intraductal breast neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A benign or malignant epithelial neoplasm that arises anywhere in the ductal system of the breast. This category includes intraductal papilloma, intraductal papillary carcinoma, ductal hyperplasia with or without atypia, and ductal carcinoma in situ."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002488"
    }
  ],
  "children": [
    {
      "id": 5858,
      "label": "flat ductal epithelial atypia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5857
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6841",
          "MEDGEN:232508",
          "NCIT:C36086",
          "UMLS:C1333620"
        ],
        "synonyms": [
          "DIN 1A",
          "FEA",
          "clinging carcinoma",
          "ductal intraepithelial neoplasia, grade 1A",
          "flat ductal epithelial atypia",
          "flat ductal epithelial atypia of the breast",
          "flat epithelial atypia",
          "flat epithelial atypia of the breast"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A breast lesion characterized by the presence of dilated terminal ductal lobular units in which the epithelial lining has been replaced by a single layer of mildly atypical cells, or there is atypical, monotonous epithelial hyperplasia of three to five layers. This lesion relates to columnar cell change with atypia and columnar cell hyperplasia with atypia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004008"
    },
    {
      "id": 6758,
      "label": "ductal breast carcinoma in situ",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5172,
        5857,
        6442,
        7234
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060074",
          "EFO:0000432",
          "ICDO:8500/2",
          "MEDGEN:765",
          "MESH:D002285",
          "NCIT:C2924",
          "ONCOTREE:DCIS",
          "UMLS:C0007124"
        ],
        "synonyms": [
          "DCIS",
          "carcinoma in situ of mammary duct",
          "ductal breast carcinoma in situ",
          "ductal carcinoma in situ",
          "ductal carcinoma in situ (DCIS)",
          "ductal carcinoma in situ of breast",
          "ductal carcinoma in situ of the breast",
          "intraductal breast carcinoma",
          "intraductal carcinoma",
          "intraductal carcinoma of breast",
          "intraductal carcinoma of the breast",
          "mammary duct carcinoma in situ",
          "mammary duct in situ carcinoma",
          "non-infiltrating ductal adenocarcinoma of breast",
          "non-infiltrating ductal adenocarcinoma of the breast",
          "non-infiltrating ductal breast adenocarcinoma",
          "non-infiltrating ductal breast carcinoma",
          "non-infiltrating ductal carcinoma of breast",
          "non-infiltrating ductal carcinoma of the breast",
          "non-infiltrating intraductal adenocarcinoma",
          "non-infiltrating intraductal adenocarcinoma of breast",
          "non-infiltrating intraductal adenocarcinoma of the breast",
          "non-infiltrating intraductal breast adenocarcinoma",
          "non-infiltrating intraductal carcinoma",
          "non-invasive ductal adenocarcinoma of breast",
          "non-invasive ductal adenocarcinoma of the breast",
          "non-invasive ductal breast adenocarcinoma",
          "non-invasive ductal breast carcinoma",
          "non-invasive ductal carcinoma of breast",
          "non-invasive ductal carcinoma of the breast",
          "non-invasive intraductal adenocarcinoma of breast",
          "non-invasive intraductal adenocarcinoma of the breast",
          "non-invasive intraductal breast adenocarcinoma",
          "stage 0 mammary duct carcinoma",
          "breast ductal carcinoma in situ"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A carcinoma entirely confined to the mammary ducts. It is also known as DCIS. There is no evidence of invasion of the basement membrane. Currently, it is classified into three categories: High-grade DCIS, intermediate-grade DCIS and low-grade DCIS. In this classification the DCIS grade is defined by a combination of nuclear grade, architectural growth pattern and presence of necrosis. The size of the lesion as well as the grade and the clearance margins play a major role in dictating the most appropriate therapy for DCIS."
      },
      "child_count": 4,
      "reference_id": "MONDO:0005023"
    },
    {
      "id": 7981,
      "label": "usual ductal breast hyperplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5857,
        6775
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000612",
          "ICD9:611.89",
          "MEDGEN:759542",
          "NCIT:C27941",
          "SCTID:472905007",
          "UMLS:C3532429"
        ],
        "synonyms": [
          "UDH",
          "ductal breast hyperplasia of usual type",
          "ordinary intraductal breast hyperplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002657",
            "name": "breast disorder"
          }
        ],
        "definition": "A neoplastic ductal proliferative lesion of the breast characterized by the formation of secondary lumens and prominent intraductal proliferation of a heterogeneous cellular population that may include epithelial cells, myoepithelial cells, or metaplastic apocrine cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006484"
    }
  ],
  "roots": [
    {
      "id": 4567,
      "label": "intraductal breast neoplasm"
    }
  ]
}