{
  "id": 5869,
  "label": "mediastinal malignant lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004021",
  "properties": {
    "xrefs": [
      "DOID:6868",
      "GARD:0023781",
      "MEDGEN:235311",
      "NCIT:C6633",
      "UMLS:C1334665"
    ],
    "synonyms": [
      "lymphoma of mediastinum",
      "lymphoma of the mediastinum",
      "mediastinal lymphoma",
      "mediastinal malignant lymphoma",
      "mediastinum lymphoma",
      "primary mediastinal lymphoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A lymphoma that arises from the mediastinum. Representative examples include mediastinal (thymic) large B-cell lymphoma and Hodgkin lymphoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6792,
      "label": "lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6881,
        16514
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060058",
          "EFO:0000574",
          "ICD9:200.0",
          "ICD9:200.1",
          "ICD9:202.80",
          "ICDO:9590/3",
          "MEDGEN:44223",
          "MESH:D008223",
          "MedDRA:10025310",
          "NANDO:2100004",
          "NCIT:C3208",
          "ONCOTREE:MLYM",
          "Orphanet:223735",
          "SCTID:118600007",
          "UMLS:C0024299"
        ],
        "synonyms": [
          "lymphoma",
          "lymphoma (Hodgkin and non-Hodgkin)",
          "lymphoma (Hodgkin's and non-Hodgkin's)",
          "lymphoma, malignant",
          "lymphomatous",
          "malignant lymphoma",
          "MLYM"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A malignant (clonal) proliferation of B- lymphocytes or T- lymphocytes which involves the lymph nodes, bone marrow and/or extranodal sites. This category includes Non-Hodgkin lymphomas and Hodgkin lymphomas."
      },
      "child_count": 54,
      "reference_id": "MONDO:0005062"
    },
    {
      "id": 7455,
      "label": "mediastinal cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5215,
        20542
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5559",
          "EFO:0007362",
          "ICD9:164.9",
          "MEDGEN:56308",
          "MESH:D008479",
          "NCIT:C3549",
          "SCTID:363494000",
          "UMLS:C0153504"
        ],
        "synonyms": [
          "mediastinal tumor",
          "mediastinal tumour",
          "tumor of mediastinum",
          "tumour of mediastinum",
          "cancer of mediastinum",
          "cancer of the mediastinum",
          "malignant mediastinal neoplasm",
          "malignant mediastinal tumor",
          "malignant mediastinal tumour",
          "malignant mediastinum neoplasm",
          "malignant neoplasm of mediastinum",
          "malignant neoplasm of the mediastinum",
          "malignant tumor of mediastinum",
          "malignant tumor of the mediastinum",
          "malignant tumour of mediastinum",
          "malignant tumour of the mediastinum",
          "mediastinal cancer",
          "mediastinum cancer"
        ],
        "definition": "A malignant neoplasm involving the mediastinum"
      },
      "child_count": 12,
      "reference_id": "MONDO:0005843"
    }
  ],
  "children": [
    {
      "id": 3220,
      "label": "thymus lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4646,
        5869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10146",
          "EFO:1000054",
          "GARD:0022852",
          "MEDGEN:277818",
          "NCIT:C6451",
          "UMLS:C1336745"
        ],
        "synonyms": [
          "Thymus lymphoma",
          "lymphoma of Thymus",
          "lymphoma of the Thymus",
          "lymphoma of thymus",
          "primary thymic lymphoma",
          "thymic lymphoma",
          "thymus lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A lymphoma that arises from the thymus. Representative examples include mediastinal (thymic) large B-cell lymphoma and Hodgkin lymphoma."
      },
      "child_count": 2,
      "reference_id": "MONDO:0000951"
    },
    {
      "id": 5868,
      "label": "mediastinal gray zone lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5545,
        5869
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6867",
          "GARD:0023780",
          "MEDGEN:233679",
          "NCIT:C37870",
          "UMLS:C1334657"
        ],
        "synonyms": [
          "mediastinal B-cell lymphoma, unclassifiable, with features Intermediate between diffuse large B-cell lymphoma and Classic Hodgkin lymphoma",
          "mediastinal B-cell lymphoma, unclassifiable, with features Intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma",
          "mediastinal Gray zone lymphoma",
          "mediastinal Grey zone lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A mediastinal lymphoma with molecular, morphologic, immunophenotypic, and clinical features of both mediastinal (thymic) large B-cell lymphoma and classical Hodgkin lymphoma. The identification of this group of lymphomas, along with recent gene expression profiling results (PDL2 gene expression in both mediastinal (thymic) large B-cell lymphoma tissues and Hodgkin lymphoma cell lines), further supports the hypothesis that mediastinal (thymic) large B-cell lymphomas and classical Hodgkin lymphomas are related entities."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004020"
    }
  ],
  "roots": [
    {
      "id": 6792,
      "label": "lymphoma"
    },
    {
      "id": 7455,
      "label": "mediastinal cancer"
    }
  ]
}