{
  "id": 5892,
  "label": "aleukemic monocytic leukemia cutis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004051",
  "properties": {
    "xrefs": [
      "DOID:6958",
      "GARD:0023794",
      "MEDGEN:231050",
      "NCIT:C5630",
      "UMLS:C1332232"
    ],
    "synonyms": [
      "aleukemic monocytic leukemia cutis"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ]
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 5609,
      "label": "aleukemic leukemia cutis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5610
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6003",
          "GARD:0006892",
          "MEDGEN:168394",
          "NCIT:C4983",
          "UMLS:C0887846"
        ],
        "synonyms": [
          "aleukemic leukemia cutis",
          "leukaemia subleukemic",
          "leukemia subleukemic"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Infiltration of the skin and subcutaneous tissue by leukemic cells without evidence of leukemia in the bone marrow and peripheral blood. It results in clinically identifiable skin lesions. It may be the first manifestation of acute leukemia, preceding the involvement of the bone marrow and peripheral blood by the leukemic process."
      },
      "child_count": 1,
      "reference_id": "MONDO:0003729"
    },
    {
      "id": 9231,
      "label": "acute monocytic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6392,
        18806
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2004-2820",
          "DOID:8864",
          "EFO:0000221",
          "GARD:0000525",
          "ICD10CM:C93.0",
          "ICD9:206.0",
          "ICDO:9891/3",
          "MEDGEN:7319",
          "MESH:D007948",
          "MedDRA:10000871",
          "MedDRA:10059439",
          "NANDO:2200008",
          "NANDO:2200009",
          "NCIT:C4861",
          "OMIM:151380",
          "ONCOTREE:AMOL",
          "Orphanet:514",
          "SCTID:413441006",
          "UMLS:C0023465",
          "icd11.foundation:517546180"
        ],
        "synonyms": [
          "monocytic leukaemia",
          "monocytic leukemia",
          "AML M5",
          "acute monoblastic leukaemia and acute monocytic leukaemia",
          "acute monocytic leukaemia (FAB M5B)",
          "acute monocytic leukaemia (FAB M5b)",
          "acute monocytic leukemia",
          "acute monocytic leukemia (FAB M5B)",
          "acute monocytic leukemia (FAB M5b)",
          "acute monocytic leukemia, morphology (morphologic abnormality)",
          "leukemia, monocytic, malignant",
          "monocytic leukemia, acute",
          "AML-M5",
          "acute monoblastic leukaemia",
          "acute monoblastic leukemia",
          "acute monoblastic/monocytic leukaemia",
          "acute monoblastic/monocytic leukemia",
          "acute myeloblastic leukaemia type 5",
          "acute myeloblastic leukemia type 5",
          "leukemia, acute monocytic"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Acute monoblastic leukemia (AML-M5), is one of the most common subtypes of acute myeloid leukemia (AML) that is either comprised of more than 80% of monoblasts (AML-M5a) or 30-80% monoblasts with (pro)monocytic differentiation (AML-M5b). AML-M5 presents with asthenia, pallor, fever, and dizziness. Specific features of AML-M5 include hyperleukocytosis, propensity for extramedullary infiltrates, coagulation abnormalities including disseminated intravascular coagulation and neurological disorders. Leukemia cutis and gingival infiltration can also be seen. A characteristic translocation observed in AML-M5 is t(9;11)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0007896"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 5609,
      "label": "aleukemic leukemia cutis"
    },
    {
      "id": 9231,
      "label": "acute monocytic leukemia"
    }
  ]
}