{
  "id": 5894,
  "label": "bartholin gland squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004053",
  "properties": {
    "xrefs": [
      "DOID:6961",
      "GARD:0023796",
      "MEDGEN:307249",
      "NCIT:C40293",
      "UMLS:C1511052"
    ],
    "synonyms": [
      "Bartholin's gland squamous cell carcinoma",
      "bartholin gland squamous cell carcinoma",
      "major vestibular gland squamous cell carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      }
    ],
    "definition": "A carcinoma that arises from the Bartholin gland and is characterized by the presence of malignant squamous epithelial cells."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 4848,
      "label": "bartholin gland carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3053,
        6931,
        20353
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3999",
          "DOID:60003",
          "EFO:1000103",
          "GARD:0023257",
          "HP:0030419",
          "MEDGEN:83888",
          "NCIT:C9055",
          "SCTID:276876007",
          "UMLS:C0349561"
        ],
        "synonyms": [
          "Bartholin gland cancer",
          "Bartholin gland carcinoma (disease)",
          "Bartholin's gland cancer",
          "Bartholin's gland carcinoma",
          "bartholin gland carcinoma",
          "carcinoma of Bartholin's gland",
          "carcinoma of major vestibular gland",
          "carcinoma of the Bartholin's gland",
          "major vestibular gland carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the Bartholin gland. It usually affects women over fifty and presents with enlargement of the Bartholin gland. Various histologic subtypes have been identified and include adenocarcinoma, squamous cell carcinoma, adenoid cystic carcinoma, adenosquamous carcinoma, transitional cell carcinoma, and small cell carcinoma."
      },
      "child_count": 12,
      "reference_id": "MONDO:0002829"
    },
    {
      "id": 21524,
      "label": "vulvar squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4318,
        6823,
        6931
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2101",
          "EFO:1000624",
          "GARD:0022005",
          "MEDGEN:79201",
          "NCIT:C4052",
          "Orphanet:494448",
          "SCTID:254895003",
          "UMLS:C0280856",
          "icd11.foundation:146824338"
        ],
        "synonyms": [
          "epidermoid carcinoma of the vulva",
          "epidermoid carcinoma of vulva",
          "epidermoid cell carcinoma of the vulva",
          "epidermoid cell carcinoma of vulva",
          "mammalian vulva squamous cell carcinoma",
          "squamous cell carcinoma of the vulva",
          "squamous cell carcinoma of vulva",
          "vulva epidermoid carcinoma",
          "vulva epidermoid cell carcinoma",
          "vulva squamous cell carcinoma",
          "vulvar epidermoid carcinoma",
          "vulvar epidermoid cell carcinoma",
          "vulvar squamous cell cancer",
          "vulvar squamous cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "An invasive squamous cell carcinoma arising from the vulva. Risk factors include the human papilloma virus and cigarette smoking. Precursor lesions include the vulvar intraepithelial neoplasia, lichen sclerosus with associated squamous cell hyperplasia, and chronic granulomatous vulvar disease such as granuloma inguinale. Symptoms include vulvar pruritus or irritation, discharge, bleeding, and pain. The following morphologic variants have been identified: keratinizing, non-keratinizing, basaloid, warty, verrucous, keratoacanthoma-like, and squamous cell carcinoma with tumor giant cells. Risk factors for recurrence include advanced stage, tumor diameter greater than 2.5 cm, multifocality, capillary-like space involvement, associated vulvar intraepithelial neoplasia grades 2 or 3, and margins of resection involved by tumor. (WHO, 2003)"
      },
      "child_count": 18,
      "reference_id": "MONDO:0024609"
    }
  ],
  "children": [
    {
      "id": 5458,
      "label": "Bartholin gland adenosquamous carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5894,
        7652
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5630",
          "GARD:0023562",
          "MEDGEN:267339",
          "NCIT:C40296",
          "UMLS:C1511050"
        ],
        "synonyms": [
          "Bartholin gland adenosquamous carcinoma",
          "Bartholin's gland adenosquamous carcinoma",
          "major vestibular gland adenosquamous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the Bartholin gland and is characterized by the presence of malignant glandular epithelial cells and malignant squamous epithelial cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003555"
    }
  ],
  "roots": [
    {
      "id": 4848,
      "label": "bartholin gland carcinoma"
    },
    {
      "id": 21524,
      "label": "vulvar squamous cell carcinoma"
    }
  ]
}