{
  "id": 5904,
  "label": "iris melanoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004064",
  "properties": {
    "xrefs": [
      "DOID:6994",
      "GARD:0023802",
      "MEDGEN:87559",
      "NCIT:C9088",
      "SCTID:255012009",
      "UMLS:C0346373"
    ],
    "synonyms": [
      "iris malignant melanoma",
      "iris melanoma",
      "iris melanoma (disease)",
      "malignant melanoma of iris",
      "malignant melanoma of the iris",
      "melanoma (disease) of iris",
      "melanoma of iris",
      "melanoma of the iris",
      "malignant iris melanoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002022",
        "name": "disorder of orbital region"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0024458",
        "name": "disorder of visual system"
      }
    ],
    "definition": "A uveal melanoma that arises from the iris. It is the most common primary malignant neoplasm of the iris. The majority arise in preexisting nevi."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4709,
      "label": "iris cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4710,
        20435
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3478",
          "MEDGEN:91103",
          "NCIT:C4554",
          "SCTID:188264002",
          "UMLS:C0346372",
          "icd11.foundation:982190055"
        ],
        "synonyms": [
          "tumor of the iris",
          "tumour of the iris",
          "cancer of iris",
          "iris cancer",
          "malignant iris neoplasm",
          "malignant iris tumor",
          "malignant iris tumour",
          "malignant neoplasm of iris",
          "malignant neoplasm of the iris",
          "malignant tumor of iris",
          "malignant tumor of the iris",
          "malignant tumour of iris",
          "malignant tumour of the iris"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A malignant neoplasm involving the iris."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002658"
    },
    {
      "id": 7983,
      "label": "uveal melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4710,
        7858
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6039",
          "EFO:1000616",
          "GARD:0008621",
          "MEDGEN:65077",
          "MESH:C536494",
          "MedDRA:10061252",
          "NCIT:C7712",
          "OMIM:155720",
          "ONCOTREE:UM",
          "Orphanet:39044",
          "UMLS:C0220633"
        ],
        "synonyms": [
          "intraocular melanoma",
          "melanoma (disease) of uvea",
          "melanoma of the uvea",
          "melanoma of uvea",
          "melanoma, uveal, malignant",
          "uvea melanoma",
          "uvea melanoma (disease)",
          "uveal melanoma",
          "iris melanoma",
          "choroidal melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A melanoma derived from melanocytes of the uveal tract. It is the most common primary intraocular tumor in the United States and Western Europe. Similar to melanoma of the skin, it is rare in Africa and Asia. Diagnostic procedures include ophthalmoscopic exam, fluorescein angiography and ultrasound. Treatment includes: surgical excision of the eye, iridocyclectomy and tumor resection. Recent treatments also include radiotherapy or photo coagulation. Classification of uveal melanomas recognizes four cell types within these tumors: epithelioid, intermediate, mixed cell, and spindle cell types. The spindle cell type uveal melanomas are further sub-classified as spindle cell type A and spindle cell type B."
      },
      "child_count": 16,
      "reference_id": "MONDO:0006486"
    }
  ],
  "children": [
    {
      "id": 5774,
      "label": "malignant ciliary body melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4973,
        5904
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6524",
          "GARD:0023730",
          "ICD9:190.8",
          "MEDGEN:138062",
          "NCIT:C4558",
          "SCTID:255015006",
          "UMLS:C0346379"
        ],
        "synonyms": [
          "ciliary body malignant melanoma",
          "ciliary body melanoma",
          "ciliary body melanoma (disease)",
          "malignant melanoma of ciliary body",
          "malignant melanoma of the ciliary body",
          "melanoma (disease) of ciliary body",
          "melanoma of ciliary body",
          "melanoma of the ciliary body"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A rare uveal melanoma that arises from the ciliary body. Patients may present with blurred vision, visual field loss, floaters, and ocular pain. The prognosis is usually poor."
      },
      "child_count": 8,
      "reference_id": "MONDO:0003912"
    },
    {
      "id": 5903,
      "label": "intermediate cell type iris melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5902,
        5904
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6993",
          "GARD:0023801",
          "MEDGEN:233564",
          "NCIT:C6101",
          "UMLS:C1334210"
        ],
        "synonyms": [
          "Intermediate cell type iris melanoma",
          "intermediate cell type uveal melanoma of iris",
          "iris intermediate cell type uveal melanoma",
          "iris mixed cell melanoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "Iris melanoma characterized by the presence of intermediate cells which are similar to but smaller than epithelioid cells."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004063"
    },
    {
      "id": 6010,
      "label": "iris spindle cell melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5624,
        5904
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7328",
          "GARD:0023867",
          "MEDGEN:232672",
          "NCIT:C6098",
          "UMLS:C1334287"
        ],
        "synonyms": [
          "iris spindle cell melanoma",
          "spindle cell melanoma of iris",
          "spindle cell melanoma of the iris"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A spindle cell melanoma that involves the iris."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004188"
    }
  ],
  "roots": [
    {
      "id": 4709,
      "label": "iris cancer"
    },
    {
      "id": 7983,
      "label": "uveal melanoma"
    }
  ]
}