{
  "id": 5945,
  "label": "refractory hematologic cancer",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004111",
  "properties": {
    "xrefs": [
      "DOID:712",
      "GARD:0023831",
      "MEDGEN:233400",
      "NCIT:C27357",
      "UMLS:C1335724"
    ],
    "synonyms": [
      "refractory hematologic cancer",
      "refractory hematologic malignancy"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A hematologic malignancy that is resistant to treatment."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 23467,
      "label": "hematopoietic and lymphoid cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4440
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025916",
          "MEDGEN:91264",
          "NCIT:C27134",
          "UMLS:C0376544"
        ],
        "synonyms": [
          "HEMOLYMPHORETICULAR tumor, malignant",
          "haematological neoplasm",
          "haematological tumour",
          "haematopoietic and lymphoid neoplasms",
          "haematopoietic cancer",
          "haematopoietic cell tumour",
          "haematopoietic malignancy, NOS",
          "haematopoietic neoplasm",
          "haematopoietic neoplasms including lymphomas",
          "haematopoietic tumour",
          "hematologic cancer",
          "hematologic malignancy",
          "hematologic neoplasm",
          "hematological neoplasm",
          "hematological tumor",
          "hematopoietic and lymphoid cell neoplasm",
          "hematopoietic and lymphoid neoplasms",
          "hematopoietic cancer",
          "hematopoietic cell tumor",
          "hematopoietic malignancy, NOS",
          "hematopoietic neoplasm",
          "hematopoietic neoplasms including lymphomas",
          "hematopoietic tumor",
          "hematopoietic, Including myeloma",
          "malignant haematopoietic neoplasm",
          "malignant hematologic neoplasm",
          "malignant hematopoietic neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm arising from hematopoietic cells found in the bone marrow, peripheral blood, lymph nodes and spleen (organs of the hematopoietic system). Hematopoietic cell neoplasms can also involve other anatomic sites (e.g. central nervous system, gastrointestinal tract), either by metastasis, direct tumor infiltration, or neoplastic transformation of extranodal lymphoid tissues. The commonest forms are the various types of leukemia, Hodgkin and non-Hodgkin lymphomas, myeloproliferative neoplasms, and myelodysplastic syndromes."
      },
      "child_count": 8,
      "reference_id": "MONDO:0044881"
    }
  ],
  "children": [
    {
      "id": 5944,
      "label": "refractory hairy cell leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5945,
        18857
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:711",
          "GARD:0023830",
          "MEDGEN:1639342",
          "NCIT:C8030",
          "UMLS:C4551546"
        ],
        "synonyms": [
          "hairy cell leukemia, refractory",
          "refractory hairy cell leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hairy cell leukemia that is resistant to treatment."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004110"
    },
    {
      "id": 6213,
      "label": "refractory precursor T-lymphoblastic lymphoma/leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5443,
        5945
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7936",
          "GARD:0023983",
          "MEDGEN:167728",
          "NCIT:C8696",
          "UMLS:C0854859"
        ],
        "synonyms": [
          "precursor T lymphoblastic lymphoma/leukemia refractory",
          "refractory T lymphoblastic leukemia/lymphoma",
          "refractory precursor T-lymphoblastic lymphoma/leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "T-lymphoblastic leukemia/lymphoma resistant to treatment"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004404"
    },
    {
      "id": 6577,
      "label": "refractory plasma cell neoplasm",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5945,
        6702
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9544",
          "GARD:0024112",
          "MEDGEN:75844",
          "NCIT:C7813",
          "UMLS:C0278620"
        ],
        "synonyms": [
          "refractory plasma cell neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A plasma cell neoplasm that is resistant to treatment."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004816"
    },
    {
      "id": 16457,
      "label": "refractory anemia with excess blasts in transformation",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5945,
        18812
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020108",
          "ICD9:238.73",
          "ICDO:9984/3",
          "MEDGEN:124692",
          "MedDRA:10038271",
          "NCIT:C27080",
          "Orphanet:168960",
          "SCTID:110000005",
          "UMLS:C0280028"
        ],
        "synonyms": [
          "RAEB-T",
          "RAEB-t"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Refractory anemia with excess blasts in transformation (RAEB-T) is characterized by dysplastic features of the myeloid and usually erythroid progenitor cells in the bone marrow and an increased number of myeloblasts in the peripheral blood. The peripheral blood blast count ranges from 20% to 30%. RAEB-T used to be a subcategory of myelodysplastic syndromes in the past. Recently, the term has been eliminated from the WHO based classification of myelodysplastic syndromes. The reason is that the percentage of peripheral blood blasts required for the diagnosis of acute myeloid leukemia has been reduced to 20%. The elimination of the RAEB-T term by the WHO experts has created confusion and ongoing arguments. Currently, according to WHO classification, the vast majority of RAEB-T cases are best classified as acute leukemias (acute leukemias with multilineage dysplasia following myelodysplastic syndrome). A minority of cases are part of RAEB-2."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015692"
    },
    {
      "id": 19279,
      "label": "myelodysplastic syndrome with multilineage dysplasia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5945,
        18812
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019069",
          "ICD10CM:D46.A",
          "ICD9:238.72",
          "ICDO:9985/3",
          "MEDGEN:208726",
          "MedDRA:10067959",
          "NCIT:C8574",
          "Orphanet:86836",
          "SCTID:415285009",
          "UMLS:C0796466"
        ],
        "synonyms": [
          "MDS-MLD",
          "RCMD",
          "refractory cytopenia with multilineage dysplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Refractory cytopenias with multilineage dysplasia (RCMD) is a frequent subtype of myelodysplastic syndrome (MDS) characterized by 1 or more cytopenias in the peripheral blood and dysplasia in 2 or more myeloid lineages."
      },
      "child_count": 4,
      "reference_id": "MONDO:0019453"
    },
    {
      "id": 23461,
      "label": "refractory cytopenia of childhood",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5945,
        23460
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025914",
          "MEDGEN:417430",
          "NCIT:C82596",
          "ONCOTREE:RCYC",
          "UMLS:C2826323",
          "icd11.foundation:699075426"
        ],
        "synonyms": [
          "RCC",
          "refractory cytopenia of childhood"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "The most common subtype of the myelodysplastic syndromes affecting children. It is characterized by persistent cytopenia with less than 5% blasts in the bone marrow and less than 2% blasts in the peripheral blood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0044874"
    }
  ],
  "roots": [
    {
      "id": 23467,
      "label": "hematopoietic and lymphoid cell neoplasm"
    }
  ]
}