{
  "id": 5948,
  "label": "esophageal small cell neuroendocrine carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004116",
  "properties": {
    "xrefs": [
      "DOID:7134",
      "GARD:0023832",
      "MEDGEN:207270",
      "NCIT:C6762",
      "UMLS:C1112474"
    ],
    "synonyms": [
      "Oat cell carcinoma of esophagus",
      "Oat cell carcinoma of the esophagus",
      "Oat cell carcinoma of the oesophagus",
      "esophageal Oat cell carcinoma",
      "esophageal small cell NEC",
      "esophageal small cell carcinoma",
      "esophageal small cell neuroendocrine carcinoma",
      "esophagus Oat cell carcinoma",
      "esophagus small cell carcinoma",
      "oesophagus Oat cell carcinoma",
      "small cell carcinoma of esophagus",
      "small cell carcinoma of oesophagus",
      "small cell carcinoma of the esophagus",
      "small cell carcinoma of the oesophagus",
      "small cell carcinoma, esophagus",
      "small cell carcinoma, oesophagus"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the esophagus. It is characterized by the presence of malignant small cells."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 2894,
      "label": "small cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050685",
          "EFO:0008524",
          "GARD:0022765",
          "ICDO:8041/3",
          "ICDO:8042/3",
          "MEDGEN:90748",
          "MESH:D018288",
          "NCIT:C3915",
          "NCIT:C4099",
          "SCTID:11010461000119101",
          "UMLS:C0334239"
        ],
        "synonyms": [
          "oat cell cancer",
          "oat cell carcinoma",
          "small cell NEC",
          "small cell cancer",
          "small cell car. (extrapulmonary)",
          "small cell carcinoma",
          "small cell carcinoma (extrapulmonary)",
          "small cell neuroendocrine carcinoma",
          "intermediate cell small cell carcinoma",
          "small cell carcinoma - intermediate cell",
          "small cell carcinoma, intermediate cell",
          "small cell carcinoma, intermediate cell (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine carcinoma composed of small malignant cells which are often said to resemble \"oat cells\" under the microscope. Small cell carcinoma most often affects the lungs. Clinically, this is often a rapidly growing cancer that spreads to distant sites early."
      },
      "child_count": 18,
      "reference_id": "MONDO:0000402"
    },
    {
      "id": 5537,
      "label": "esophageal neuroendocrine tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2885,
        20522
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5784",
          "GARD:0022058",
          "MEDGEN:459486",
          "NCIT:C95616",
          "Orphanet:506136",
          "UMLS:C2987260",
          "icd11.foundation:1167478749",
          "icd11.foundation:890879256"
        ],
        "synonyms": [
          "NEN of esophagus",
          "NEN of oesophagus",
          "esophageal NEN",
          "esophageal NET",
          "esophageal neuroendocrine neoplasm",
          "esophageal neuroendocrine tumor",
          "esophageal well differentiated endocrine tumor",
          "esophageal well differentiated endocrine tumor/carcinoma",
          "esophageal well differentiated endocrine tumour",
          "esophagus NET",
          "esophagus neuroendocrine neoplasm",
          "esophagus neuroendocrine tumor",
          "esophagus neuroendocrine tumor, well differentiated, low or intermediate grade",
          "neuroendocrine neoplasm of esophagus",
          "neuroendocrine neoplasm of oesophagus",
          "neuroendocrine tumour of oesophagus",
          "oesophagus NET",
          "oesophagus neuroendocrine neoplasm",
          "oesophagus neuroendocrine tumor, well differentiated, low or intermediate grade",
          "oesophagus neuroendocrine tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A well differentiated, low or intermediate grade tumor with neuroendocrine differentiation that arises from the esophagus."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003649"
    },
    {
      "id": 18977,
      "label": "carcinoma of esophagus",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7738,
        8953
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1107",
          "EFO:0002916",
          "GARD:0006383",
          "MEDGEN:56256",
          "MedDRA:10030155",
          "NCIT:C3513",
          "Orphanet:70482",
          "SCTID:372138000",
          "UMLS:C0152018"
        ],
        "synonyms": [
          "Esophageal cancer",
          "carcinoma of esophagus",
          "carcinoma of the esophagus",
          "carcinoma of the oesophagus",
          "esophageal carcinoma",
          "esophagus carcinoma",
          "oesophagus carcinoma",
          "cancer of esophagus",
          "cancer of oesophagus",
          "cancer of the esophagus",
          "cancer of the oesophagus",
          "esophageal cancer",
          "esophageal cancer, NOS"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "Esophageal carcinoma (EC) is a tumor arising in the epithelial cells lining the esophagus and can be divided into two subtypes: esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC)."
      },
      "child_count": 10,
      "reference_id": "MONDO:0019086"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 2894,
      "label": "small cell carcinoma"
    },
    {
      "id": 5537,
      "label": "esophageal neuroendocrine tumor"
    },
    {
      "id": 18977,
      "label": "carcinoma of esophagus"
    }
  ]
}