{
  "id": 5949,
  "label": "ampulla of vater small cell neuroendocrine carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004117",
  "properties": {
    "xrefs": [
      "DOID:7136",
      "GARD:0023833",
      "MEDGEN:233974",
      "NCIT:C6655",
      "UMLS:C1332250"
    ],
    "synonyms": [
      "ampulla of Vater small cell NEC",
      "ampulla of Vater small cell carcinoma",
      "ampulla of Vater small cell neuroendocrine carcinoma",
      "ampullary small cell carcinoma",
      "hepatopancreatic ampulla small cell carcinoma",
      "small cell neuroendocrine carcinoma of the ampullary region"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An aggressive neuroendocrine carcinoma arising from the ampulla of Vater and the periampullary region. Morphologically, it is characterized by the presence of small malignant cells, necrosis, and a high mitotic rate. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 2894,
      "label": "small cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050685",
          "EFO:0008524",
          "GARD:0022765",
          "ICDO:8041/3",
          "ICDO:8042/3",
          "MEDGEN:90748",
          "MESH:D018288",
          "NCIT:C3915",
          "NCIT:C4099",
          "SCTID:11010461000119101",
          "UMLS:C0334239"
        ],
        "synonyms": [
          "oat cell cancer",
          "oat cell carcinoma",
          "small cell NEC",
          "small cell cancer",
          "small cell car. (extrapulmonary)",
          "small cell carcinoma",
          "small cell carcinoma (extrapulmonary)",
          "small cell neuroendocrine carcinoma",
          "intermediate cell small cell carcinoma",
          "small cell carcinoma - intermediate cell",
          "small cell carcinoma, intermediate cell",
          "small cell carcinoma, intermediate cell (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine carcinoma composed of small malignant cells which are often said to resemble \"oat cells\" under the microscope. Small cell carcinoma most often affects the lungs. Clinically, this is often a rapidly growing cancer that spreads to distant sites early."
      },
      "child_count": 18,
      "reference_id": "MONDO:0000402"
    },
    {
      "id": 16046,
      "label": "liver neuroendocrine carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4255,
        18551,
        21456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019760",
          "MEDGEN:474664",
          "NCIT:C96787",
          "Orphanet:100085",
          "SCTID:716652006",
          "UMLS:C3273031"
        ],
        "synonyms": [
          "HNEC",
          "PHNEC",
          "hepatic neuroendocrine carcinoma",
          "liver neuroendocrine cancer",
          "liver neuroendocrine carcinoma",
          "neuroendocrine carcinoma of liver",
          "primary hepatic neuroendocrine carcinoma",
          "primary liver neuroendocrine carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An extremely rare, aggressive, high-grade and poorly differentiated carcinoma with neuroendocrine differentiation that arises from the liver."
      },
      "child_count": 6,
      "reference_id": "MONDO:0015072"
    },
    {
      "id": 17870,
      "label": "carcinoma of the ampulla of vater",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3189,
        5076,
        20511
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4932",
          "EFO:1000079",
          "GARD:0021237",
          "MEDGEN:120461",
          "MedDRA:10048853",
          "NCIT:C3908",
          "ONCOTREE:AMPCA",
          "Orphanet:300557",
          "SCTID:254609000",
          "UMLS:C0262401",
          "icd11.foundation:267067189"
        ],
        "synonyms": [
          "Ampulloma",
          "ampulla of Vater cancer",
          "ampulla of Vater carcinoma",
          "ampullary cancer",
          "ampullary carcinoma",
          "carcinoma of ampulla of vater",
          "carcinoma of hepatopancreatic ampulla",
          "hepatopancreatic ampulla carcinoma",
          "AMPCA"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma arising from the ampulla of Vater. The vast majority of cases are adenocarcinomas. Signs and symptoms include jaundice, abdominal pain, anorexia, nausea, vomiting, and weight loss."
      },
      "child_count": 9,
      "reference_id": "MONDO:0017590"
    },
    {
      "id": 21453,
      "label": "duodenal neuroendocrine neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18542,
        20534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025403",
          "MEDGEN:1800031",
          "UMLS:C5568608",
          "icd11.foundation:1585809486"
        ],
        "synonyms": [
          "duodenum NET",
          "duodenum neuroendocrine neoplasm",
          "duodenum neuroendocrine tumor",
          "duodenum neuroendocrine tumor, well differentiated, low or intermediate grade",
          "duodenum neuroendocrine tumour",
          "neuroendocrine neoplasm of duodenum"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A neuroendocrine neoplasm that involves the duodenum."
      },
      "child_count": 4,
      "reference_id": "MONDO:0024500"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 2894,
      "label": "small cell carcinoma"
    },
    {
      "id": 16046,
      "label": "liver neuroendocrine carcinoma"
    },
    {
      "id": 17870,
      "label": "carcinoma of the ampulla of vater"
    },
    {
      "id": 21453,
      "label": "duodenal neuroendocrine neoplasm"
    }
  ]
}