{
  "id": 5961,
  "label": "anal canal squamous cell carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004132",
  "properties": {
    "xrefs": [
      "DOID:7177",
      "GARD:0021774",
      "MEDGEN:233979",
      "NCIT:C7469",
      "Orphanet:424019",
      "UMLS:C1332262",
      "icd11.foundation:585238371"
    ],
    "synonyms": [
      "anal canal squamous cell carcinoma",
      "squamous cell carcinoma of the anal canal"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "A squamous cell carcinoma arising from the mucosa of the anal canal."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 7659,
      "label": "anal squamous cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5158,
        18545
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5525",
          "EFO:1000081",
          "GARD:0024286",
          "MEDGEN:237257",
          "NCIT:C9161",
          "ONCOTREE:ANSC",
          "UMLS:C1412036"
        ],
        "synonyms": [
          "anal squamous cell cancer",
          "anal squamous cell carcinoma",
          "anus squamous cell carcinoma",
          "epidermoid anal carcinoma",
          "epidermoid carcinoma of anus",
          "epidermoid carcinoma of the anus",
          "squamous cell anal carcinoma",
          "squamous cell carcinoma - anus",
          "squamous cell carcinoma of anus",
          "squamous cell carcinoma of the anus",
          "ANSC"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A squamous cell carcinoma (SCC) arising from the anal canal or the anal margin (perianal skin). Human papillomavirus is detected in the majority of cases. Homosexual HIV-positive men have an increased risk of developing anal squamous cell carcinoma in comparison to the general male population. Symptoms include anal pruritus, discomfort when sitting, pain, change in bowel habit, and bleeding. The prognosis is generally better for anal margin SCC than for anal canal SCC."
      },
      "child_count": 8,
      "reference_id": "MONDO:0006082"
    },
    {
      "id": 8521,
      "label": "anal canal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2895,
        5158,
        18546
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6126",
          "GARD:0021772",
          "MEDGEN:107559",
          "NCIT:C7489",
          "OMIM:105580",
          "Orphanet:424013",
          "SCTID:285310000",
          "UMLS:C0563211"
        ],
        "synonyms": [
          "anal canal cancer",
          "anal canal and perianal gland cancer",
          "anal canal and perianal gland carcinoma",
          "anal canal carcinoma",
          "carcinoma of anal canal",
          "carcinoma of the anal canal",
          "cloacogenic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the anal canal"
      },
      "child_count": 15,
      "reference_id": "MONDO:0007108"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 7659,
      "label": "anal squamous cell carcinoma"
    },
    {
      "id": 8521,
      "label": "anal canal carcinoma"
    }
  ]
}