{
  "id": 5979,
  "label": "chronic lymphocytic leukemia/small lymphocytic lymphoma with immunoglobulin heavy chain variable-region gene somatic hypermutation",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004152",
  "properties": {
    "xrefs": [
      "DOID:7230",
      "GARD:0023852",
      "MEDGEN:232076",
      "NCIT:C37201",
      "UMLS:C1333037"
    ],
    "synonyms": [
      "CLL/SLL with IGVH SHM",
      "chronic lymphocytic leukemia/small lymphocytic lymphoma with immunoglobulin heavy chain variable-region gene somatic hypermutation",
      "postgerminal center chronic lymphocytic leukemia/small lymphocytic lymphoma",
      "postgerminal centre chronic lymphocytic leukemia/small lymphocytic lymphoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A recently recognized variant of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) expressing somatic hypermutations of the Immunoglobulin heavy chain (IGH) genes. The recognition of this variant alters the belief that CLL/SLL is always derived from a naive, pregerminal center B-cell. The presence of somatic hypermutations of IGH genes occurs in approximately 50% of CLL/SLL cases and implies a postgerminal center, memory origin. Patients with this variant of CLL/SLL have a favorable prognosis, with a reported median survival of more than 24 years."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 5729,
      "label": "chronic lymphocytic leukemia/small lymphocytic lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6693
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6354",
          "GARD:0023704",
          "ICDO:9823/3",
          "MEDGEN:224906",
          "NCIT:C27911",
          "ONCOTREE:CLLSLL",
          "UMLS:C1302547"
        ],
        "synonyms": [
          "CLL/SLL",
          "chronic lymphocytic leukemia/small lymphocytic lymphoma",
          "chronic lymphocytic leukemia/small lymphocytic lymphoma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An indolent, mature B-cell neoplasm composed of small, round B-lymphocytes. When the bone marrow and peripheral blood are involved, the term chronic lymphocytic leukemia is used. The term small lymphocytic lymphoma is restricted to cases which do not show leukemic involvement of the bone marrow and peripheral blood."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003864"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 5729,
      "label": "chronic lymphocytic leukemia/small lymphocytic lymphoma"
    }
  ]
}