{
  "id": 5990,
  "label": "selective IgD deficiency disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004165",
  "properties": {
    "xrefs": [
      "DOID:7263",
      "GARD:0023858",
      "ICD9:279.03",
      "MEDGEN:96021",
      "NCIT:C27144",
      "SCTID:234541006",
      "UMLS:C0398695"
    ],
    "synonyms": [
      "selective IgD immunodeficiency"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A rare dysgammaglobulinemia characterized by low or undetectable serum levels of immunoglobulin class D (IgD). It is an uncommon primary antibody deficiency. It is most likely an inherited immunodeficiency. It may be caused by decreased or inefficient production of IgD from progenitor B cells without any corresponding decreases in the other isotypes. Most affected persons are asymptomatic and do not appear to be at increased risk for infection."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 5619,
      "label": "selective immunoglobulin deficiency disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4332
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6025",
          "GARD:0023643",
          "MEDGEN:235584",
          "NCIT:C27870",
          "UMLS:C1335942"
        ],
        "synonyms": [
          "selective Immunoglobulin isotype deficiency"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A broad classification of dysgammaglobulinemias characterized by low or undetectable serum levels of one of the five immunoglobulin classes. Deficiencies of immunoglobulins present variably according to isotype. Selective deficiencies may be caused by decreased or inefficient production from progenitor B cells without any corresponding decreases in the other isotypes. The clinical course and prognosis is dependent upon the severity of the selective deficiency and associated morbidity."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003739"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 5619,
      "label": "selective immunoglobulin deficiency disease"
    }
  ]
}