{
  "id": 6094,
  "label": "osteosarcoma arising in bone Paget disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004275",
  "properties": {
    "xrefs": [
      "DOID:7542",
      "GARD:0023906",
      "ICDO:9184/3",
      "MEDGEN:569679",
      "NCIT:C6469",
      "UMLS:C0334546"
    ],
    "synonyms": [
      "Paget osteosarcoma",
      "Paget's osteosarcoma",
      "osteosarcoma arising in Paget disease of bone",
      "osteosarcoma arising in Paget's disease of bone",
      "osteosarcoma arising in bone Paget's disease",
      "osteosarcoma arising in osseous Paget's disease",
      "osteosarcoma arising in osteitis deformans"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      }
    ],
    "definition": "A sarcomatous transformation of pre-existing Paget disease of the bone. Osteosarcomas arising from Paget disease of the bone are high grade lesions and usually have a poor prognosis."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4505,
      "label": "bone carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4262,
        6734
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2762",
          "GARD:0023132"
        ],
        "synonyms": [
          "bone element carcinoma",
          "carcinoma of bone element"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A carcinoma that involves the bone element."
      },
      "child_count": 14,
      "reference_id": "MONDO:0002415"
    },
    {
      "id": 4680,
      "label": "bone osteosarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        11016,
        20297
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3376",
          "GARD:0007284",
          "ICD9:170.9",
          "MEDGEN:108437",
          "MedDRA:10031291",
          "NCIT:C53707",
          "OMIM:259500",
          "Orphanet:668",
          "SCTID:307576001",
          "UMLS:C0585442"
        ],
        "synonyms": [
          "bone osteosarcoma",
          "osteosarcoma of bone",
          "osteosarcoma, somatic",
          "osteosarcoma, somatic mutation"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          }
        ],
        "definition": "A usually aggressive malignant bone-forming mesenchymal neoplasm arising from the bone. It may arise de novo or from a pre-existing lesion of the bone. Pain and a palpable mass are the most frequent clinical sign and symptom. It may spread to other anatomic sites, particularly the lungs."
      },
      "child_count": 10,
      "reference_id": "MONDO:0002629"
    },
    {
      "id": 20398,
      "label": "Paget disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6712
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:277958",
          "NCIT:C7073",
          "UMLS:C1368019"
        ],
        "synonyms": [
          "Paget cell neoplasm",
          "Paget disease",
          "Paget's cell neoplasm",
          "Paget's disease"
        ],
        "definition": "A malignant neoplasm composed of large cells with large nuclei, prominent nucleoli, and abundant pale cytoplasm (Paget cells). Paget cell neoplasms include Paget disease of the nipple and extramammary Paget disease which may affect the vulva, penis, anus, skin and scrotum."
      },
      "child_count": 5,
      "reference_id": "MONDO:0021165"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4505,
      "label": "bone carcinoma"
    },
    {
      "id": 4680,
      "label": "bone osteosarcoma"
    },
    {
      "id": 20398,
      "label": "Paget disease"
    }
  ]
}