{
  "id": 6102,
  "label": "pancreatic intraductal papillary-mucinous carcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004285",
  "properties": {
    "xrefs": [
      "DOID:7574",
      "GARD:0021779",
      "MEDGEN:235451",
      "NCIT:C5725",
      "Orphanet:424058",
      "UMLS:C1335304",
      "icd11.foundation:2086328209"
    ],
    "synonyms": [
      "intraductal papillary mucinous carcinoma of pancreas",
      "intraductal papillary-mucinous carcinoma of pancreas",
      "pancreatic intraductal papillary mucinous carcinoma",
      "pancreatic intraductal papillary-mucinous carcinoma",
      "intraductal papillary-colloid carcinoma of pancreas",
      "intraductal papillary-colloid carcinoma of the pancreas",
      "intraductal papillary-colloidal carcinoma of pancreas",
      "intraductal papillary-colloidal carcinoma of the pancreas",
      "intraductal papillary-mucinous carcinoma of the pancreas",
      "pancreatic intraductal papillary-colloid carcinoma",
      "pancreatic intraductal papillary-colloidal carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A malignant glandular neoplasm arising from the exocrine pancreas. Microscopically it is characterized by the presence of mucoid stroma formation, papillary patterns, and cystic changes. It has been associated with KRAS and Tp53 gene mutations."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 6912,
      "label": "exocrine pancreatic carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4251,
        7738
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4905",
          "EFO:0002618",
          "GARD:0027717",
          "MEDGEN:65917",
          "NCIT:C3850",
          "SCTID:372142002",
          "UMLS:C0235974"
        ],
        "synonyms": [
          "cancer of pancreas",
          "cancer of the pancreas",
          "exocrine cancer",
          "pancreas cancer",
          "pancreatic cancer",
          "carcinoma of exocrine pancreas",
          "carcinoma of the pancreas",
          "exocrine pancreas carcinoma",
          "pancreas carcinoma",
          "pancreatic cancer (not islets)",
          "pancreatic carcinoma, familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the exocrine pancreas"
      },
      "child_count": 16,
      "reference_id": "MONDO:0005192"
    }
  ],
  "children": [
    {
      "id": 6145,
      "label": "pancreatic intraductal papillary-mucinous neoplasm with high grade dysplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6102,
        6103
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7685",
          "GARD:0023941",
          "ICDO:8453/2",
          "MEDGEN:275330",
          "NCIT:C41251",
          "UMLS:C1518873"
        ],
        "synonyms": [
          "pancreatic intraductal papillary mucinous neoplasm with high grade dysplasia",
          "pancreatic intraductal papillary-mucinous neoplasm with high grade dysplasia",
          "pancreatic non-invasive intraductal papillary-mucinous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-invasive pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that exhibit loss of polarity, nuclear stratification, hyperchromasia, and pleomorphism. There is severe architectural atypia and frequent mitotic figures present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004329"
    },
    {
      "id": 6284,
      "label": "pancreatic intraductal papillary-mucinous neoplasm with an associated invasive carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6102,
        6103,
        7633
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8150",
          "GARD:0024028",
          "ICDO:8453/3",
          "MEDGEN:275329",
          "NCIT:C5726",
          "UMLS:C1518871"
        ],
        "synonyms": [
          "pancreatic intraductal papillary mucinous neoplasm with an associated invasive carcinoma",
          "pancreatic intraductal papillary-mucinous neoplasm with an associated invasive carcinoma",
          "pancreatic invasive intraductal papillary-mucinous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of a focal or multifocal invasive carcinomatous component. The invasive carcinoma is either colloid or ductal adenocarcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004481"
    }
  ],
  "roots": [
    {
      "id": 6912,
      "label": "exocrine pancreatic carcinoma"
    }
  ]
}