{
  "id": 6103,
  "label": "pancreatic intraductal papillary-mucinous neoplasm",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004286",
  "properties": {
    "xrefs": [
      "DOID:7575",
      "GARD:0027673",
      "MEDGEN:1373306",
      "NCIT:C38342",
      "ONCOTREE:IPMN",
      "UMLS:C4511687"
    ],
    "synonyms": [
      "IPMN",
      "pancreatic IPMN",
      "pancreatic intraductal papillary-mucinous neoplasm",
      "pancreatic intraductal papillary-mucinous tumor",
      "pancreatic intraductal papillary-mucinous tumour",
      "intraductal papillary mucinous neoplasm"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A usually slow-growing epithelial neoplasm with ductal differentiation that arises from the exocrine pancreas and grows mostly within the pancreatic ducts. Grossly, it is characterized by the presence of intraductal masses. Morphologically, there is proliferation of mucin-producing cells within the pancreatic ducts, intraductal accumulation of mucin, and a papillary growth pattern. It may be associated with the presence of an invasive carcinoma. It usually occurs in older patients. Signs and symptoms include epigastric pain, weight loss, jaundice, chronic pancreatitis, and diabetes mellitus."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4251,
      "label": "malignant exocrine pancreas neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        11035,
        20317
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1795",
          "GARD:0027598",
          "MEDGEN:91108",
          "NCIT:C7430",
          "SCTID:255088001",
          "UMLS:C0346648"
        ],
        "synonyms": [
          "pancreatic exocrine tumor",
          "pancreatic exocrine tumour",
          "cancer of exocrine pancreas",
          "exocrine pancreas cancer",
          "malignant exocrine pancreas neoplasm",
          "malignant exocrine pancreas tumor",
          "malignant exocrine pancreas tumour",
          "malignant neoplasm of exocrine pancreas",
          "malignant neoplasm of the exocrine pancreas",
          "malignant tumor of exocrine pancreas",
          "malignant tumor of the exocrine pancreas",
          "malignant tumour of the exocrine pancreas",
          "tumor of exocrine pancreas",
          "tumour of exocrine pancreas"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant neoplasm that arises from the epithelial cells of the exocrine pancreatic tissue."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002116"
    }
  ],
  "children": [
    {
      "id": 6145,
      "label": "pancreatic intraductal papillary-mucinous neoplasm with high grade dysplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6102,
        6103
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7685",
          "GARD:0023941",
          "ICDO:8453/2",
          "MEDGEN:275330",
          "NCIT:C41251",
          "UMLS:C1518873"
        ],
        "synonyms": [
          "pancreatic intraductal papillary mucinous neoplasm with high grade dysplasia",
          "pancreatic intraductal papillary-mucinous neoplasm with high grade dysplasia",
          "pancreatic non-invasive intraductal papillary-mucinous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-invasive pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that exhibit loss of polarity, nuclear stratification, hyperchromasia, and pleomorphism. There is severe architectural atypia and frequent mitotic figures present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004329"
    },
    {
      "id": 6194,
      "label": "pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6103
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7851",
          "GARD:0027679",
          "ICDO:8453/0",
          "MEDGEN:274118",
          "NCIT:C41249",
          "SCTID:473418001",
          "UMLS:C1518868"
        ],
        "synonyms": [
          "pancreatic intraductal papillary mucinous neoplasm with Low grade dysplasia",
          "pancreatic intraductal papillary-mucinous adenoma",
          "pancreatic intraductal papillary-mucinous neoplasm with Low grade dysplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A non-invasive pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that form a single layer and are well polarized. The neoplastic cells exhibit small and uniform nuclei, mild pleomorphism, and rare mitotic figures."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004381"
    },
    {
      "id": 6284,
      "label": "pancreatic intraductal papillary-mucinous neoplasm with an associated invasive carcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6102,
        6103,
        7633
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8150",
          "GARD:0024028",
          "ICDO:8453/3",
          "MEDGEN:275329",
          "NCIT:C5726",
          "UMLS:C1518871"
        ],
        "synonyms": [
          "pancreatic intraductal papillary mucinous neoplasm with an associated invasive carcinoma",
          "pancreatic intraductal papillary-mucinous neoplasm with an associated invasive carcinoma",
          "pancreatic invasive intraductal papillary-mucinous carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A pancreatic intraductal papillary mucinous neoplasm characterized by the presence of a focal or multifocal invasive carcinomatous component. The invasive carcinoma is either colloid or ductal adenocarcinoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004481"
    }
  ],
  "roots": [
    {
      "id": 4251,
      "label": "malignant exocrine pancreas neoplasm"
    }
  ]
}