{
  "id": 6145,
  "label": "pancreatic intraductal papillary-mucinous neoplasm with high grade dysplasia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004329",
  "properties": {
    "xrefs": [
      "DOID:7685",
      "GARD:0023941",
      "ICDO:8453/2",
      "MEDGEN:275330",
      "NCIT:C41251",
      "UMLS:C1518873"
    ],
    "synonyms": [
      "pancreatic intraductal papillary mucinous neoplasm with high grade dysplasia",
      "pancreatic intraductal papillary-mucinous neoplasm with high grade dysplasia",
      "pancreatic non-invasive intraductal papillary-mucinous carcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A non-invasive pancreatic intraductal papillary mucinous neoplasm characterized by the presence of neoplastic epithelial cells that exhibit loss of polarity, nuclear stratification, hyperchromasia, and pleomorphism. There is severe architectural atypia and frequent mitotic figures present."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6102,
      "label": "pancreatic intraductal papillary-mucinous carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6912
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7574",
          "GARD:0021779",
          "MEDGEN:235451",
          "NCIT:C5725",
          "Orphanet:424058",
          "UMLS:C1335304",
          "icd11.foundation:2086328209"
        ],
        "synonyms": [
          "intraductal papillary mucinous carcinoma of pancreas",
          "intraductal papillary-mucinous carcinoma of pancreas",
          "pancreatic intraductal papillary mucinous carcinoma",
          "pancreatic intraductal papillary-mucinous carcinoma",
          "intraductal papillary-colloid carcinoma of pancreas",
          "intraductal papillary-colloid carcinoma of the pancreas",
          "intraductal papillary-colloidal carcinoma of pancreas",
          "intraductal papillary-colloidal carcinoma of the pancreas",
          "intraductal papillary-mucinous carcinoma of the pancreas",
          "pancreatic intraductal papillary-colloid carcinoma",
          "pancreatic intraductal papillary-colloidal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant glandular neoplasm arising from the exocrine pancreas. Microscopically it is characterized by the presence of mucoid stroma formation, papillary patterns, and cystic changes. It has been associated with KRAS and Tp53 gene mutations."
      },
      "child_count": 2,
      "reference_id": "MONDO:0004285"
    },
    {
      "id": 6103,
      "label": "pancreatic intraductal papillary-mucinous neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4251
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7575",
          "GARD:0027673",
          "MEDGEN:1373306",
          "NCIT:C38342",
          "ONCOTREE:IPMN",
          "UMLS:C4511687"
        ],
        "synonyms": [
          "IPMN",
          "pancreatic IPMN",
          "pancreatic intraductal papillary-mucinous neoplasm",
          "pancreatic intraductal papillary-mucinous tumor",
          "pancreatic intraductal papillary-mucinous tumour",
          "intraductal papillary mucinous neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A usually slow-growing epithelial neoplasm with ductal differentiation that arises from the exocrine pancreas and grows mostly within the pancreatic ducts. Grossly, it is characterized by the presence of intraductal masses. Morphologically, there is proliferation of mucin-producing cells within the pancreatic ducts, intraductal accumulation of mucin, and a papillary growth pattern. It may be associated with the presence of an invasive carcinoma. It usually occurs in older patients. Signs and symptoms include epigastric pain, weight loss, jaundice, chronic pancreatitis, and diabetes mellitus."
      },
      "child_count": 3,
      "reference_id": "MONDO:0004286"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6102,
      "label": "pancreatic intraductal papillary-mucinous carcinoma"
    },
    {
      "id": 6103,
      "label": "pancreatic intraductal papillary-mucinous neoplasm"
    }
  ]
}