{
  "id": 6152,
  "label": "rectal signet ring cell adenocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004336",
  "properties": {
    "xrefs": [
      "DOID:7707",
      "MEDGEN:124641",
      "NCIT:C9168",
      "UMLS:C0279654"
    ],
    "synonyms": [
      "rectal signet Ring cell adenocarcinoma",
      "rectum signet ring cell carcinoma",
      "signet Ring adenocarcinoma of rectum",
      "signet Ring adenocarcinoma of the rectum",
      "signet Ring cell adenocarcinoma of rectum",
      "signet Ring cell adenocarcinoma of the rectum",
      "rectum signet ring adenocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "An infiltrating adenocarcinoma arising from the rectum. It is characterized by the presence of malignant glandular cells with prominent intracytoplasmic mucin. These cells constitute more than 50% of the malignant cellular population."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4295,
      "label": "rectum adenocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6746,
        23485
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1996",
          "EFO:0005631",
          "MEDGEN:56214",
          "NCIT:C9383",
          "ONCOTREE:READ",
          "SCTID:254582000",
          "UMLS:C0149978",
          "icd11.foundation:1316028436"
        ],
        "synonyms": [
          "adenocarcinoma - rectum",
          "adenocarcinoma of rectum",
          "adenocarcinoma of the rectum",
          "rectal adenocarcinoma",
          "rectum adenocarcinoma",
          "read"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An adenocarcinoma arising from the rectum. It is more frequently seen in populations with a Western type diet and in patients with a history of chronic inflammatory bowel disease. Signs and symptoms include intestinal bleeding, anemia, and change in bowel habits. According to the degree of cellular differentiation, rectal adenocarcinomas are divided into well, moderately, and poorly differentiated. Histologic variants include mucinous adenocarcinoma, signet ring cell carcinoma, medullary carcinoma, serrated adenocarcinoma, cribriform comedo-type adenocarcinoma, and micropapillary adenocarcinoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0002169"
    },
    {
      "id": 23338,
      "label": "colorectal signet ring cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6746,
        6819
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:313040",
          "NCIT:C43586",
          "UMLS:C1707440"
        ],
        "synonyms": [
          "colorectal signet Ring cell carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "An invasive colorectal adenocarcinoma characterized by the presence of malignant glandular epithelial cells with prominent intracytoplasmic mucin resulting in the displacement of the nuclei. The malignant glandular cells with intracytoplasmic mucin constitute more than 50% of the malignant cellular infiltrate."
      },
      "child_count": 4,
      "reference_id": "MONDO:0044336"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4295,
      "label": "rectum adenocarcinoma"
    },
    {
      "id": 23338,
      "label": "colorectal signet ring cell carcinoma"
    }
  ]
}