{
  "id": 6153,
  "label": "perianal skin Paget disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004337",
  "properties": {
    "xrefs": [
      "DOID:7708",
      "GARD:0023944",
      "MEDGEN:231372",
      "NCIT:C7476",
      "UMLS:C1332270"
    ],
    "synonyms": [
      "Paget disease of the anal margin",
      "Paget's disease of the anal margin",
      "anal margin Paget's disease",
      "perianal skin Paget disease",
      "perianal skin Paget's disease",
      "perianal skin mammary Paget's disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      }
    ],
    "definition": "Paget disease involving the perianal skin."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4702,
      "label": "anal Paget disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4703,
        9488
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3446",
          "GARD:0023203",
          "MEDGEN:233981",
          "NCIT:C5598",
          "UMLS:C1332274"
        ],
        "synonyms": [
          "Paget disease of the anus",
          "Paget's disease of anus",
          "Paget's disease of the anus",
          "anal Paget disease",
          "anal Paget's disease",
          "anus Paget disease",
          "anus mammary Paget's disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A slowly spreading, erythematous eczematoid plaque in the anal region. Histologically, the basal part or whole thickness of the squamous epithelium is infiltrated by large cells with abundant pale cytoplasm and large nuclei. Half of the cases are associated with an internal malignancy, most often a colorectal adenocarcinoma. The other half of the cases, have a high local recurrence rate and they may become invasive (WHO)."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002651"
    },
    {
      "id": 4706,
      "label": "cutaneous Paget disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4707,
        20398
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3450"
        ],
        "synonyms": [
          "cutaneous Paget's disease",
          "zone of skin Paget disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          }
        ],
        "definition": "A skin carcinoma that is characterized by infiltration of the skin by neoplastic large cells with abundant pale cytoplasm and large nuclei with prominent nucleoli."
      },
      "child_count": 2,
      "reference_id": "MONDO:0002655"
    },
    {
      "id": 4946,
      "label": "anal margin carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4707,
        5158
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4284",
          "GARD:0027626",
          "MEDGEN:87604",
          "NCIT:C7472",
          "UMLS:C0349534"
        ],
        "synonyms": [
          "anal margin cancer",
          "anal margin carcinoma",
          "carcinoma of anal margin",
          "carcinoma of perianal skin",
          "carcinoma of the anal margin",
          "perianal skin carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          }
        ],
        "definition": "A carcinoma that arises from epithelial cells of the perianal skin"
      },
      "child_count": 6,
      "reference_id": "MONDO:0002941"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4702,
      "label": "anal Paget disease"
    },
    {
      "id": 4706,
      "label": "cutaneous Paget disease"
    },
    {
      "id": 4946,
      "label": "anal margin carcinoma"
    }
  ]
}