{
  "id": 6161,
  "label": "signet ring cell intrahepatic cholangiocarcinoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004346",
  "properties": {
    "xrefs": [
      "DOID:7733",
      "GARD:0023949",
      "MEDGEN:276815",
      "NCIT:C41619",
      "UMLS:C1519321"
    ],
    "synonyms": [
      "signet Ring cell intrahepatic cholangiocarcinoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An intrahepatic cholangiocarcinoma characterized by the presence of signet ring adenocarcinoma cells."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4713,
      "label": "extrahepatic bile duct signet ring cell carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4714,
        6819
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3494",
          "GARD:0023204",
          "MEDGEN:163667",
          "NCIT:C5776",
          "UMLS:C0861859"
        ],
        "synonyms": [
          "bile duct signet Ring cell carcinoma",
          "bile duct signet ring cell carcinoma",
          "extrahepatic bile duct signet Ring cell carcinoma",
          "signet Ring cell bile duct carcinoma",
          "signet Ring cell carcinoma of bile duct",
          "signet Ring cell carcinoma of the bile duct"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An adenocarcinoma that arises from the extrahepatic bile ducts. It is characterized by the presence of signet ring malignant epithelial cells."
      },
      "child_count": 4,
      "reference_id": "MONDO:0002664"
    },
    {
      "id": 5166,
      "label": "intrahepatic cholangiocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3698,
        18978
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4928",
          "EFO:1001961",
          "GARD:0006042",
          "ICD10CM:C22.1",
          "MEDGEN:87521",
          "NCIT:C35417",
          "ONCOTREE:IHCH",
          "SCTID:109842005",
          "UMLS:C0345905",
          "icd11.foundation:1253728223",
          "icd11.foundation:387909164"
        ],
        "synonyms": [
          "ICC",
          "cholangiocarcinoma, intrahepatic, malignant",
          "intrahepatic Cholangiocellular carcinoma",
          "intrahepatic bile duct cancer (cholangiocarcinoma)",
          "intrahepatic bile duct carcinoma",
          "intrahepatic carcinoma of bile duct",
          "intrahepatic carcinoma of the bile duct",
          "intrahepatic cholangiocarcinoma",
          "intrahepatic cholangiocarcinoma (bile duct cancer)",
          "IHCH"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A carcinoma that arises from the intrahepatic bile duct epithelium in any site of the intrahepatic biliary tree. Grossly, the malignant lesions are solid, nodular, and grayish. Morphologically, the vast majority of cases are adenocarcinomas. Signs and symptoms include malaise, weight loss, right upper quadrant abdominal pain, and night sweats. Early detection is difficult and the prognosis is generally poor."
      },
      "child_count": 12,
      "reference_id": "MONDO:0003210"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4713,
      "label": "extrahepatic bile duct signet ring cell carcinoma"
    },
    {
      "id": 5166,
      "label": "intrahepatic cholangiocarcinoma"
    }
  ]
}