{
  "id": 6193,
  "label": "dendritic cell sarcoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0004380",
  "properties": {
    "xrefs": [
      "DOID:7849",
      "GARD:0019082",
      "MEDGEN:226984",
      "NCIT:C27260",
      "ONCOTREE:DCS",
      "Orphanet:86903",
      "SCTID:446643000",
      "UMLS:C1301364"
    ],
    "synonyms": [
      "dendritic cell sarcoma",
      "sarcoma of dendritic cell"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A sarcoma that involves the dendritic cell."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 3028,
      "label": "immune system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733,
        6778
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060083"
        ],
        "synonyms": [
          "cancer of immune system",
          "immune system cancer",
          "malignant immune system neoplasm",
          "malignant neoplasm of immune system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the immune system"
      },
      "child_count": 50,
      "reference_id": "MONDO:0000621"
    },
    {
      "id": 6569,
      "label": "leukocyte disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778,
        7217
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9500",
          "ICD9:288",
          "ICD9:288.9",
          "MEDGEN:7325",
          "MESH:D007960",
          "SCTID:54097007",
          "UMLS:C0023510"
        ],
        "synonyms": [
          "disease of leukocyte",
          "disease or disorder of leukocyte",
          "disorder of leukocyte",
          "disorder, leukocyte",
          "disorders, leukocyte",
          "leukocyte disease",
          "leukocyte disease or disorder",
          "leukocyte disorder",
          "white blood cell disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A disease involving leukocytes."
      },
      "child_count": 46,
      "reference_id": "MONDO:0004805"
    },
    {
      "id": 6816,
      "label": "sarcoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1115",
          "EFO:0000691",
          "ICD9:171",
          "ICD9:171.0",
          "ICD9:171.2",
          "ICD9:171.3",
          "ICD9:171.4",
          "ICD9:171.5",
          "ICD9:171.6",
          "ICD9:171.7",
          "ICD9:171.8",
          "ICD9:171.9",
          "ICDO:8800/3",
          "MEDGEN:224714",
          "MESH:D012509",
          "NCIT:C9118",
          "SCTID:424413001",
          "UMLS:C1261473"
        ],
        "synonyms": [
          "mesenchymal tumor, malignant",
          "sarcoma",
          "sarcoma of soft tissue and bone",
          "sarcoma of the soft tissue and bone",
          "sarcoma, malignant",
          "tumor of soft tissue and skeleton",
          "tumour of soft tissue and skeleton"
        ],
        "definition": "A usually aggressive malignant neoplasm of the soft tissue or bone. It arises from muscle, fat, fibrous tissue, bone, cartilage, and blood vessels. Sarcomas occur in both children and adults. The prognosis depends largely on the degree of differentiation (grade) of the neoplasm. Representative subtypes are liposarcoma, leiomyosarcoma, osteosarcoma, and chondrosarcoma."
      },
      "child_count": 22,
      "reference_id": "MONDO:0005089"
    },
    {
      "id": 19729,
      "label": "dendritic cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7797
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008317",
          "MEDGEN:1842732",
          "Orphanet:98289",
          "SCTID:737223000",
          "UMLS:C5681852"
        ],
        "synonyms": [
          "dendritic cell sarcoma, NOS",
          "dendritic cell sarcoma, Not otherwise specified",
          "dendritic cell tumor, NOS",
          "dendritic cell tumor, not otherwise specified",
          "dendritic cell neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A dendritic cell tumor develops from the cells of the immune system. This condition typically begins in the lymph system and may spread to nearby organs or distant parts of the body (metastasize). The symptoms and severity of the condition depend on the subtype and location of the tumor."
      },
      "child_count": 3,
      "reference_id": "MONDO:0020082"
    }
  ],
  "children": [
    {
      "id": 7384,
      "label": "follicular dendritic cell sarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6193,
        17662
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6262",
          "EFO:0007276",
          "GARD:0019081",
          "ICDO:9758/1",
          "ICDO:9758/3",
          "MEDGEN:220355",
          "MESH:D054740",
          "NANDO:2200034",
          "NCIT:C9281",
          "ONCOTREE:FDCS",
          "Orphanet:86902",
          "UMLS:C1260325",
          "icd11.foundation:149373156",
          "icd11.foundation:15445528"
        ],
        "synonyms": [
          "follicular Dendritic cell sarcoma",
          "follicular Dendritic cell sarcoma/tumor",
          "follicular dendritic cell sarcoma",
          "follicular dendritic cell tumor",
          "sarcoma of follicular dendritic cell"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm composed of spindle to ovoid cells which have morphologic and immunophenotypic characteristics of follicular dendritic cells. It affects lymph nodes and other sites including the tonsils, gastrointestinal tract, spleen, liver, soft tissues, skin, and oral cavity. It usually behaves as a low grade sarcoma. Treatment options include complete surgical removal of the tumor with or without adjuvant chemotherapy or radiotherapy. Recurrences have been reported in up to half of the cases."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005764"
    },
    {
      "id": 7429,
      "label": "interdigitating dendritic cell sarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6193
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7848",
          "EFO:0007329",
          "GARD:0024234",
          "ICDO:9757/1",
          "ICDO:9757/3",
          "MEDGEN:266040",
          "MESH:D054739",
          "NANDO:2200035",
          "NCIT:C9282",
          "ONCOTREE:IDCS",
          "SCTID:715664005",
          "UMLS:C1260326",
          "icd11.foundation:2024362257",
          "icd11.foundation:214592620"
        ],
        "synonyms": [
          "interdigitating cell sarcoma",
          "interdigitating Dendritic cell sarcoma",
          "interdigitating Dendritic cell sarcoma/tumor",
          "interdigitating cell sarcoma/tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplastic proliferation of spindle to ovoid cells which show phenotypic features similar to those of interdigitating dendritic cells. The clinical course is generally aggressive. (WHO, 2008)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0005813"
    },
    {
      "id": 19304,
      "label": "Langerhans cell sarcoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6193
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7146",
          "EFO:0007336",
          "GARD:0010491",
          "ICDO:9756/3",
          "MEDGEN:266041",
          "MESH:D054752",
          "NANDO:2200036",
          "NCIT:C6921",
          "ONCOTREE:LCS",
          "Orphanet:86897",
          "SCTID:724649000",
          "UMLS:C1260327",
          "icd11.foundation:588958190",
          "icd11.foundation:933337476"
        ],
        "synonyms": [
          "Langerhans cell sarcoma",
          "sarcoma of Langerhans cell",
          "LCS",
          "malignant Langerhans cell sarcoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplastic proliferation of Langerhans cells with overtly malignant cytologic features. It can be considered a higher grade variant of Langerhans cell histiocytosis (LCH) and it can present de novo or progress from antecedent LCH. (WHO, 2001)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0019480"
    }
  ],
  "roots": [
    {
      "id": 3028,
      "label": "immune system cancer"
    },
    {
      "id": 6569,
      "label": "leukocyte disorder"
    },
    {
      "id": 6816,
      "label": "sarcoma"
    },
    {
      "id": 19729,
      "label": "dendritic cell tumor"
    }
  ]
}